Senior Computer Biologist
My main focus is the improvement of helminth genome assemblies, drawing together various sequence, mapping and synteny data. Much of my work involves careful inspection of assembly data in Gap5, and working with scientists and bioinformaticians to develop algorithms to solve complex assembly issues. This approach produces world-class reference quality assemblies.
I am currently working on improving the genome assemblies of Haemonchus contortus and Schistosoma mansoni. Here the challenge has been to merge new PacBio data with existing mature assemblies and optical mapping data to produce greatly improved hybrid assemblies. In addition to genome assembly improvement I am also actively engaged in improving the structural and functional annotation of gene models currently focusing on S. mansoni.