Dr Alistair Dunham
Understanding protein function using computational analysis and large CRISPR and biochemical mutationals screens.
I work on understanding the function of proteins by measuring and modelling the consequences of coding mutations, with a particular current interest in the properties of protein interfaces. We perform some mutational screens in the group, using gene editing approaches in cells and developing biochemical methods and I incorporate these, as well as similar MAVE data, into joint computational analyses.
Programmes and Facilities
Generative and Synthetic Genomics
The Generative and Synthetic Genomics Programme combines large-scale data generation and artificial intelligence to lay the foundations for predictive and programmable ...
The Human Genetics Programme is driving a step-change in our understanding of genetic causes and biological mechanisms of disease susceptibility and ...