Thrilled to share my ultimate PhD project at @steinaerts' lab on designing cell-type specific synthetic enhancers! We implemented three different design strategies guided by our previously trained deep learning models on fly brain enhancers. Link: https://bit.ly/3oAILXS (1/n)
Very cool: use protein language model likelihood to approximate intrinsic protein fitness, to evolve e.g. antibodies towards improved affinity - without knowledge of the antigen! Includes improvement of anti-spike Abs, while training data predates the pandemic.