I am investigating the sequence determinants of regulatory activity using machine learning methods.
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Awesome paper from @JD_Buenrostro lab about modelling protein occupancy with chromatin accessibility data at different scales - I especially like the sliding nucleosomes during diff. + Tn5 bias models (trained on data from deproteinised BACs) - useful! https://www.biorxiv.org/content/10.1101/2023.03.28.533945v1.full.pdf
Enjoyed this new paper by the @BashorLab where they profile pooled DNA libraries of any length - the combination of Nanopore to build a barcode-gene circuit dictionary and Illumina to sequence the barcode is very nice! Nice ML models too https://www.biorxiv.org/content/10.1101/2023.03.16.532704v1.full.pdf
Had a great time meeting people and seeing lots of exciting research at #SynBioFH23 ! Already looking forward to the next iteration :)