Anderson Group | Genomics of inflammation and immunity

Anderson Group | Genomics of inflammation and immunity

Anderson Group

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Our Research and Approach

The immune system must maintain a delicate balance; it should be sensitive enough to eliminate invading pathogens while being tolerant of the body's own cells. Immune-mediated diseases can occur when the immune system gets this balance wrong and attacks cells and substances typically found in the body. These diseases are known to "run in families", suggesting that inherited genetic risk factors play a role in susceptibility. The aim of our research is to improve our understanding of immune-mediated diseases by identifying and functionally characterising the specific regions of the genome that influence disease risk, progression and response to therapy. We undertake both computational and wet lab research in order to achieve these goals. The Anderson Lab currently consists of 18 people from a diverse range of backgrounds, including genetics, mathematics, medicine, computer science, cell biology and immunology. 

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People

Dr Carl Anderson
Group Leader

Carl is a statistical geneticist interested in using genetic and genomic data to further our understanding of common complex diseases. He heads the Genomics of Inflammation and Immunity group at the Sanger Institute. He is also the Institute's Director of Graduate Studies.

Henry, Rachel

Henry, Rachel
Rachel Henry
Team Administrator - Human Genetics
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Alumni

Key Projects, Collaborations, Tools & Data

Programmes, Associate Research Programmes and Facilities

Partners and Funders

Our research is highly collaborative and we are fortunate to work with many great scientists and clinicians from all around the world.
Internal Partners
External Partners and Funders

Publications

  • HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

    Sazonovs A, Kennedy NA, Moutsianas L, Heap GA, Rice DL et al.

    Gastroenterology 2019

  • Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

    Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J et al.

    Nature genetics 2017;49;2;186-192

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

    de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y et al.

    Nature genetics 2017;49;2;256-261

  • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease.

    Ji SG, Juran BD, Mucha S, Folseraas T, Jostins L et al.

    Nature genetics 2017;49;2;269-273

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

    Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R et al.

    Nature genetics 2015;47;9;979-986

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

    Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM et al.

    Nature genetics 2013;45;6;670-5

  • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

    Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L et al.

    Nature genetics 2012;44;10;1137-41

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M et al.

    Nature genetics 2011;43;3;246-52

  • Incomplete genetic reconstitution of B cell pools contributes to prolonged immunosuppression after measles.

    Petrova VN, Sawatsky B, Han AX, Laksono BM, Walz L et al.

    Science immunology 2019;4;41

  • HLA-DQA1*05 Carriage Associated With Development of Anti-Drug Antibodies to Infliximab and Adalimumab in Patients With Crohn's Disease.

    Sazonovs A, Kennedy NA, Moutsianas L, Heap GA, Rice DL et al.

    Gastroenterology 2019

  • Integrative analysis of gene expression, DNA methylation, physiological traits, and genetic variation in human skeletal muscle.

    Taylor DL, Jackson AU, Narisu N, Hemani G, Erdos MR et al.

    Proceedings of the National Academy of Sciences of the United States of America 2019;116;22;10883-10888

  • Factors Associated With Outcomes of Patients With Primary Sclerosing Cholangitis and Development and Validation of a Risk Scoring System.

    Goode EC, Clark AB, Mells GF, Srivastava B, Spiess K et al.

    Hepatology (Baltimore, Md.) 2019;69;5;2120-2135

  • Association of Genetic Variants in NUDT15 With Thiopurine-Induced Myelosuppression in Patients With Inflammatory Bowel Disease.

    Walker GJ, Harrison JW, Heap GA, Voskuil MD, Andersen V et al.

    JAMA 2019;321;8;773-785

  • Amino acid residues in five separate HLA genes can explain most of the known associations between the MHC and primary biliary cholangitis.

    Darlay R, Ayers KL, Mells GF, Hall LS, Liu JZ et al.

    PLoS genetics 2018;14;12;e1007833

  • Homozygous loss-of-function mutations in SLC26A7 cause goitrous congenital hypothyroidism.

    Cangul H, Liao XH, Schoenmakers E, Kero J, Barone S et al.

    JCI insight 2018;3;20

  • Genetic association analysis identifies variants associated with disease progression in primary sclerosing cholangitis.

    Alberts R, de Vries EMG, Goode EC, Jiang X, Sampaziotis F et al.

    Gut 2018;67;8;1517-1524

  • Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

    Quaranta M, Wilson R, Gonçalves Serra E, Pandey S, Schwerd T et al.

    Gastroenterology 2018;155;1;231-234

  • BoostMe accurately predicts DNA methylation values in whole-genome bisulfite sequencing of multiple human tissues.

    Zou LS, Erdos MR, Taylor DL, Chines PS, Varshney A et al.

    BMC genomics 2018;19;1;390

  • Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia.

    Petrova VN, Muir L, McKay PF, Vassiliou GS, Smith KGC et al.

    Frontiers in immunology 2018;9;1784

  • Interactions between genetic variation and cellular environment in skeletal muscle gene expression.

    Taylor DL, Knowles DA, Scott LJ, Ramirez AH, Casale FP et al.

    PloS one 2018;13;4;e0195788

  • Fine-mapping inflammatory bowel disease loci to single-variant resolution.

    Huang H, Fang M, Jostins L, Umićević Mirkov M, Boucher G et al.

    Nature 2017;547;7662;173-178

  • Genetic regulatory signatures underlying islet gene expression and type 2 diabetes.

    Varshney A, Scott LJ, Welch RP, Erdos MR, Chines PS et al.

    Proceedings of the National Academy of Sciences of the United States of America 2017;114;9;2301-2306

  • Exploring the genetic architecture of inflammatory bowel disease by whole-genome sequencing identifies association at ADCY7.

    Luo Y, de Lange KM, Jostins L, Moutsianas L, Randall J et al.

    Nature genetics 2017;49;2;186-192

  • Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

    Lee JC, Biasci D, Roberts R, Gearry RB, Mansfield JC et al.

    Nature genetics 2017;49;2;262-268

  • Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease.

    de Lange KM, Moutsianas L, Lee JC, Lamb CA, Luo Y et al.

    Nature genetics 2017;49;2;256-261

  • Comprehensive Screening of Eight Known Causative Genes in Congenital Hypothyroidism With Gland-in-Situ.

    Nicholas AK, Serra EG, Cangul H, Alyaarubi S, Ullah I et al.

    The Journal of clinical endocrinology and metabolism 2016;101;12;4521-4531

  • A reference panel of 64,976 haplotypes for genotype imputation.

    McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR et al.

    Nature genetics 2016;48;10;1279-83

  • A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis.

    Rivas MA, Graham D, Sulem P, Stevens C, Desch AN et al.

    Nature communications 2016;7;12342

  • The genetic regulatory signature of type 2 diabetes in human skeletal muscle.

    Scott LJ, Erdos MR, Huyghe JR, Welch RP, Beck AT et al.

    Nature communications 2016;7;11764

  • Genome-wide rare copy number variation screening in ulcerative colitis identifies potential susceptibility loci.

    Saadati HR, Wittig M, Helbig I, Häsler R, Anderson CA et al.

    BMC medical genetics 2016;17;26

  • Class II HLA interactions modulate genetic risk for multiple sclerosis.

    Moutsianas L, Jostins L, Beecham AH, Dilthey AT, Xifara DK et al.

    Nature genetics 2015;47;10;1107-13

  • International genome-wide meta-analysis identifies new primary biliary cirrhosis risk loci and targetable pathogenic pathways.

    Cordell HJ, Han Y, Mells GF, Li Y, Hirschfield GM et al.

    Nature communications 2015;6;8019

  • Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations.

    Liu JZ, van Sommeren S, Huang H, Ng SC, Alberts R et al.

    Nature genetics 2015;47;9;979-986

  • Genetics in PSC: what do the "risk genes" teach us?

    Folseraas T, Liaskou E, Anderson CA and Karlsen TH

    Clinical reviews in allergy & immunology 2015;48;2-3;154-64

  • Generation of primary human intestinal T cell transcriptomes reveals differential expression at genetic risk loci for immune-mediated disease.

    Raine T, Liu JZ, Anderson CA, Parkes M and Kaser A

    Gut 2015;64;2;250-9

  • High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis.

    Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L et al.

    Nature genetics 2015;47;2;172-9

  • Monoallelic and biallelic mutations in MAB21L2 cause a spectrum of major eye malformations.

    Rainger J, Pehlivan D, Johansson S, Bengani H, Sanchez-Pulido L et al.

    American journal of human genetics 2014;94;6;915-23

  • Genetic studies of Crohn's disease: past, present and future.

    Liu JZ and Anderson CA

    Best practice & research. Clinical gastroenterology 2014;28;3;373-86

  • Heterozygous loss-of-function mutations in YAP1 cause both isolated and syndromic optic fissure closure defects.

    Williamson KA, Rainger J, Floyd JA, Ansari M, Meynert A et al.

    American journal of human genetics 2014;94;2;295-302

  • Host genetic variants and gene expression patterns associated with Epstein-Barr virus copy number in lymphoblastoid cell lines.

    Houldcroft CJ, Petrova V, Liu JZ, Frampton D, Anderson CA et al.

    PloS one 2014;9;10;e108384

  • Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.

    International Multiple Sclerosis Genetics Consortium (IMSGC), Beecham AH, Patsopoulos NA, Xifara DK, Davis MF et al.

    Nature genetics 2013;45;11;1353-60

  • Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants.

    Parker SC, Stitzel ML, Taylor DL, Orozco JM, Erdos MR et al.

    Proceedings of the National Academy of Sciences of the United States of America 2013;110;44;17921-6

  • Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway.

    Lee JC, Espéli M, Anderson CA, Linterman MA, Pocock JM et al.

    Cell 2013;155;1;57-69

  • Dense genotyping of immune-related disease regions identifies nine new risk loci for primary sclerosing cholangitis.

    Liu JZ, Hov JR, Folseraas T, Ellinghaus E, Rushbrook SM et al.

    Nature genetics 2013;45;6;670-5

  • Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.

    Jostins L, Ripke S, Weersma RK, Duerr RH, McGovern DP et al.

    Nature 2012;491;7422;119-24

  • Dense fine-mapping study identifies new susceptibility loci for primary biliary cirrhosis.

    Liu JZ, Almarri MA, Gaffney DJ, Mells GF, Jostins L et al.

    Nature genetics 2012;44;10;1137-41

  • optiCall: a robust genotype-calling algorithm for rare, low-frequency and common variants.

    Shah TS, Liu JZ, Floyd JA, Morris JA, Wirth N et al.

    Bioinformatics (Oxford, England) 2012;28;12;1598-603

  • Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.

    Mells GF, Floyd JA, Morley KI, Cordell HJ, Franklin CS et al.

    Nature genetics 2011;43;4;329-32

  • Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.

    Anderson CA, Boucher G, Lees CW, Franke A, D'Amato M et al.

    Nature genetics 2011;43;3;246-52

  • Synthetic associations are unlikely to account for many common disease genome-wide association signals.

    Anderson CA, Soranzo N, Zeggini E and Barrett JC

    PLoS biology 2011;9;1;e1000580

  • Genome-wide association study identifies a locus at 7p15.2 associated with endometriosis.

    Painter JN, Anderson CA, Nyholt DR, Macgregor S, Lin J et al.

    Nature genetics 2011;43;1;51-4

  • Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

    Franke A, McGovern DP, Barrett JC, Wang K, Radford-Smith GL et al.

    Nature genetics 2010;42;12;1118-25

  • Data quality control in genetic case-control association studies.

    Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP and Zondervan KT

    Nature protocols 2010;5;9;1564-73

  • Meta-analysis and imputation refines the association of 15q25 with smoking quantity.

    Liu JZ, Tozzi F, Waterworth DM, Pillai SG, Muglia P et al.

    Nature genetics 2010;42;5;436-40

  • Tryptophan depletion and formation of alpha-aminoadipic and gamma-glutamic semialdehydes in porcine burger patties with added phenolic-rich fruit extracts.

    Ganhão R, Morcuende D and Estévez M

    Journal of agricultural and food chemistry 2010;58;6;3541-8

  • Common variants at five new loci associated with early-onset inflammatory bowel disease.

    Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V et al.

    Nature genetics 2009;41;12;1335-40

  • Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

    UK IBD Genetics Consortium, Barrett JC, Lee JC, Lees CW, Prescott NJ et al.

    Nature genetics 2009;41;12;1330-4

  • Investigation of Crohn's disease risk loci in ulcerative colitis further defines their molecular relationship.

    Anderson CA, Massey DC, Barrett JC, Prescott NJ, Tremelling M et al.

    Gastroenterology 2009;136;2;523-9.e3

  • Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.

    Barrett JC, Hansoul S, Nicolae DL, Cho JH, Duerr RH et al.

    Nature genetics 2008;40;8;955-62

  • Evaluating the effects of imputation on the power, coverage, and cost efficiency of genome-wide SNP platforms.

    Anderson CA, Pettersson FH, Barrett JC, Zhuang JJ, Ragoussis J et al.

    American journal of human genetics 2008;83;1;112-9

  • Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease.

    Fisher SA, Tremelling M, Anderson CA, Gwilliam R, Bumpstead S et al.

    Nature genetics 2008;40;6;710-2

  • Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility.

    Parkes M, Barrett JC, Prescott NJ, Tremelling M, Anderson CA et al.

    Nature genetics 2007;39;7;830-2