We carry out our research both here at Sanger and at our fieldsites in Uganda, Kenya, and Mali. We are working to answer the following questions using a variety of genomic tools from whole genome sequencing to single cell RNAseq.
How has natural selection shaped the genomes of wild mosquitoes, and what is the impact of this on parasite transmission and vector control?
How do human malaria parasites behave inside of the human host to enhance their probability of transmission?
How will gene drive work in the face of so much genetic diversity segregating within African Anopheles species?
What genes are important for determining mosquito susceptibility to human malaria parasites? And how much does this depend on the parasite genotype and the bacteria/viruses/fungi inside the mosquito?