Dr Angela Goncalves

Former Postdoctoral Fellow at the Sanger Institute

Alumni

This person is a member of Sanger Institute Alumni.

Welcome to my research page. I am a computational biologist interested in uncovering genetic (and non-genetic) bases for the molecular and functional variability observed in human pluripotent stem cells.

I was one of the analysts of the Human Induced Pluripotent Stem Cell Initiative – HipSci – a consortium generating a large collection of human iPSCs from healthy donors. Using computational and statistical methods, I sought to identify the relative contribution of various biological and technical predictors to variation in transcription, epigenetic marking and differentiation potential of stem cell lines. I am also interested in the origin and clonal evolution of DNA lesions in normal tissues which can lead to the development of cancer and I was a member of the Early Detection Programme of the Cambridge Cancer Centre.

Before joining Sanger, I trained with Alvis Brazma for a PhD in Molecular Biology at the European Bioinformatics Institute (EBI-EMBL) and the University of Cambridge. There I worked on computational methods for the analysis of RNA sequencing data and applied them to study the divergence of gene expression and isoform usage in mammals. Earlier still, I have spent a year at the Centre for Earth Observation of the European Space Agency (ESA), working on a toolbox for analysing remote sensing satellite data and did my undergraduate at the University of Coimbra, Portugal, where I studied Computer Science.

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Just out in @nature one of the most interesting discoveries I have had the privilege to witness and participate

Pervasive lesion segregation shapes cancer genome evolution.

https://rdcu.be/b49w4