Vitalii Kleshchevnikov

PhD Student

I am investigating how gene expression states of cells are linked to cell contact neighbourhoods in tissues. Cataloging and comparing the patterns of cell-cell contacts, their transcriptional dependencies and consequences is essential for understanding the molecular rules that govern both the structure of tissues and the context-dependent cell functions.

I use single-cell transcriptomics of isolated cells, highly-multiplexed large-scale in-situ quantification of gene expression and systems biology tools to characterise transcriptional states of neighbouring cells. To interpret scRNA-seq & spatial gene expression and ask quantitative questions I develop probabilistic models of the underlying generative process.

My timeline

• PhD @ Wellcome Sanger Institute & University of Cambridge

• Visiting Scientist @ Parts group, Wellcome Sanger Institute

• Intern @ Petsalaki group, European Bioinformatics Institute

• MSc @ Taras Shevchenko National University of Kyiv

• Intern @ Colin Stewart lab, Institute of Medical Biology, A*STAR

• BUSS Summer School @ University of Zurich & ETH Zurich

• BSc @ Taras Shevchenko National University of Kyiv