Archive Page: High throughput gene editing | Cellular Operations

Archive Page: High throughput gene editing | Cellular Operations

High throughput gene editing

The High-Throughput and Gene Editing team was disbanded in 2019 with the formation of the new Gene Editing team at the Sanger Institute. This page is being maintained as a historical record of the team's work at the Institute and is no longer being updated.
High Throughput Gene Editing Team
High Throughput Gene Editing Team

Our Research and Approach

The High Throughput Gene Editing team helped to deliver the gene editing requirements of the Institute's faculty and research.

We did this by:

  • Supporting the gene editing needs of the Institutes varied research programmes, through the adoption of modern genome editing techniques.
  • We aimed to optimise and develop genome editing tools and platforms to provide an agile, project focused, cost effective and efficient service for our collaborating partners.
  • We provided training, resources and technical support for research groups and their staff.

People

Dovey, Oliver
Dr Oliver M Dovey
Group Leader

Oliver leads the Gene Editing, Cellular Operations group. Having started his career as a research assistant at the Sanger Institute, with the Microarray Facility (lead by Cordelia Langford) and the Mouse Genetics team (lead by Prof. Allan Bradley), he obtained his PhD from the University of Leicester with Prof. Shaun Cowley studying the molecular and physiological effects of chromatin modifying proteins through the use of engineered Stem Cells and murine models. From here he returned to the Sanger Institute to study Haematological Cancer Genetics with Prof. George Vassiliou. Using bespoke engineered murine models, reverse (CRISPR-ko) and forward (transposon mediated insertional mutagenesis) screening platforms he worked to determine the physiological, molecular, pharmacological and genetic interactions (as well as sensitivities) of Acute Myeloid Leukaemia. He took up post as Head of Cellular Operations Gene Editing Team (formerly High Throughput Gene Editing) in 2018 and his team perform experiments which require Genome Engineering and develop an array of Gene Editing tools and platforms for the Institute.

Show Alumni

Alumni

Key Projects, Collaborations, Tools & Data

Partners and Funders

Internal Partners

Publications

  • Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.

    Yeung ATY, Hale C, Lee AH, Gill EE, Bushell W et al.

    Nature communications 2017;8;15013

  • One-step generation of conditional and reversible gene knockouts.

    Andersson-Rolf A, Mustata RC, Merenda A, Kim J, Perera S et al.

    Nature methods 2017;14;3;287-289