Cancer Genome Project | Cancer Genetics & Genomics

Cancer Genome Project | Cancer Genetics & Genomics

Cancer Genome Project

cgp.jpgSanger Institute, Genome Research Limited

Our Research and Approach

Cancer is caused by the genetic changes acquired by our cells as we go through life. We use cutting-edge DNA sequencing methods to identify these genetic changes, known as mutations, from human cancer samples. Our aim is to discover the genes that are frequently mutated in tumours, since these provide important insights into the biology of cancer. We also study the patterns of mutations we see in cancer cells. These patterns represent a record of the cancer's life history, and can illustrate the damaging factors the genome has been exposed to as the cancer has evolved from a normal cell.


Campbell, Peter
Peter Campbell
Group Leader

Peter Campbell's research programme focuses on the genetic changes our cells acquire as we go through life, and how these mutations are related to ageing, cancer and other disease processes.

Professor Sir Mike Stratton, FMedSci FRS
Group Leader

Mike Stratton is the Director of the Wellcome Sanger Institute and Chief Executive Officer of the Wellcome Genome Campus.

His primary research interests have been in the genetics of cancer. His early research focused on inherited susceptibility. Mike mapped and identified the major high-risk breast cancer susceptibility gene BRCA2 and subsequently a series of moderate-risk breast cancer and other cancer susceptibility genes.

Show Alumni


Nik-Zainal, Serena

Dr Serena Nik-Zainal
CRUK Advanced Clinician Scientist and Former Wellcome Sanger Institute Group Leader

Petljak, Mia

Mia Petljak
Former Postdoctoral Fellow at the Sanger Institute

Key Projects, Collaborations, Tools & Data

Programmes, Associate Research Programmes and Facilities

Partners and Funders

Internal Partners


  • Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

    Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al.

    Science (New York, N.Y.) 2015;348;6237;880-6

  • Prospective derivation of a living organoid biobank of colorectal cancer patients.

    van de Wetering M, Francies HE, Francis JM, Bounova G, Iorio F et al.

    Cell 2015;161;4;933-45

  • Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

    Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL et al.

    Science (New York, N.Y.) 2014;345;6196;1251343

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC et al.

    Nature 2014;513;7518;422-425

  • Signatures of mutational processes in human cancer.

    Alexandrov LB, Nik-Zainal S, Wedge DC, Aparicio SA, Behjati S et al.

    Nature 2013;500;7463;415-21

  • The landscape of cancer genes and mutational processes in breast cancer.

    Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C et al.

    Nature 2012;486;7403;400-4

  • Mutational processes molding the genomes of 21 breast cancers.

    Nik-Zainal S, Alexandrov LB, Wedge DC, Van Loo P, Greenman CD et al.

    Cell 2012;149;5;979-93

  • The life history of 21 breast cancers.

    Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD et al.

    Cell 2012;149;5;994-1007

  • Systematic identification of genomic markers of drug sensitivity in cancer cells.

    Garnett MJ, Edelman EJ, Heidorn SJ, Greenman CD, Dastur A et al.

    Nature 2012;483;7391;570-5

  • Genome sequencing and analysis of the Tasmanian devil and its transmissible cancer.

    Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ et al.

    Cell 2012;148;4;780-91

  • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.

    Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P et al.

    The New England journal of medicine 2011;365;15;1384-95

  • Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

    Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR et al.

    Cell 2011;144;1;27-40

  • The patterns and dynamics of genomic instability in metastatic pancreatic cancer.

    Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED et al.

    Nature 2010;467;7319;1109-13

  • Signatures of mutation and selection in the cancer genome.

    Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S et al.

    Nature 2010;463;7283;893-8

  • Complex landscapes of somatic rearrangement in human breast cancer genomes.

    Stephens PJ, McBride DJ, Lin ML, Varela I, Pleasance ED et al.

    Nature 2009;462;7276;1005-10

  • A comprehensive catalogue of somatic mutations from a human cancer genome.

    Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ et al.

    Nature 2010;463;7278;191-6

  • A small-cell lung cancer genome with complex signatures of tobacco exposure.

    Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A et al.

    Nature 2010;463;7278;184-90

  • Genome Sequencing during a Patient's Journey through Cancer.

    Nangalia J and Campbell PJ

    The New England journal of medicine 2019;381;22;2145-2156

  • Molecular Evolution of IDH Wild-Type Glioblastomas Treated With Standard of Care Affects Survival and Design of Precision Medicine Trials: A Report From the EORTC 1542 Study.

    Draaisma K, Chatzipli A, Taphoorn M, Kerkhof M, Weyerbrock A et al.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019;JCO1900367

  • Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

    Guo T, Luna A, Rajapakse VN, Koh CC, Wu Z et al.

    iScience 2019;21;664-680

  • Epigenetic modifiers DNMT3A and BCOR are recurrently mutated in CYLD cutaneous syndrome.

    Davies HR, Hodgson K, Schwalbe E, Coxhead J, Sinclair N et al.

    Nature communications 2019;10;1;4717

  • The landscape of somatic mutation in normal colorectal epithelial cells.

    Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA et al.

    Nature 2019;574;7779;532-537

  • Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.

    Brunner SF, Roberts ND, Wylie LA, Moore L, Aitken SJ et al.

    Nature 2019;574;7779;538-542

  • Cohesin-dependent regulation of gene expression during differentiation is lost in Cohesin-mutated myeloid malignancies.

    Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T et al.

    Blood 2019

  • SigProfilerMatrixGenerator: a tool for visualizing and exploring patterns of small mutational events.

    Bergstrom EN, Huang MN, Mahto U, Barnes M, Stratton MR et al.

    BMC genomics 2019;20;1;685

  • Genomic landscape and chronological reconstruction of driver events in multiple myeloma.

    Maura F, Bolli N, Angelopoulos N, Dawson KJ, Leongamornlert D et al.

    Nature communications 2019;10;1;3835

  • Patient-derived xenografts and matched cell lines identify pharmacogenomic vulnerabilities in colorectal cancer.

    Lazzari L, Corti G, Picco G, Isella C, Montone M et al.

    Clinical cancer research : an official journal of the American Association for Cancer Research 2019

  • Somatic evolution and global expansion of an ancient transmissible cancer lineage.

    Baez-Ortega A, Gori K, Strakova A, Allen JL, Allum KM et al.

    Science (New York, N.Y.) 2019;365;6452

  • Comparative performances of machine learning methods for classifying Crohn Disease patients using genome-wide genotyping data.

    Romagnoni A, Jégou S, Van Steen K, Wainrib G, Hugot JP and International Inflammatory Bowel Disease Genetics Consortium (IIBDGC)

    Scientific reports 2019;9;1;10351

  • Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

    Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C et al.

    Cancer cell 2019

  • A practical guide for mutational signature analysis in hematological malignancies.

    Maura F, Degasperi A, Nadeu F, Leongamornlert D, Davies H et al.

    Nature communications 2019;10;1;2969

  • Community assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen.

    Menden MP, Wang D, Mason MJ, Szalai B, Bulusu KC et al.

    Nature communications 2019;10;1;2674

  • Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma.

    Maura F, Agnelli L, Leongamornlert D, Bolli N, Chan WC et al.

    American journal of hematology 2019;94;6;628-634

  • Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

    Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R et al.

    Leukemia 2019

  • Functional linkage of gene fusions to cancer cell fitness assessed by pharmacological and CRISPR-Cas9 screening.

    Picco G, Chen ED, Alonso LG, Behan FM, Gonçalves E et al.

    Nature communications 2019;10;1;2198

  • Partially methylated domains are hypervariable in breast cancer and fuel widespread CpG island hypermethylation.

    Brinkman AB, Nik-Zainal S, Simmer F, Rodríguez-González FG, Smid M et al.

    Nature communications 2019;10;1;1749

  • Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

    Ly P, Brunner SF, Shoshani O, Kim DH, Lan W et al.

    Nature genetics 2019;51;4;705-715

  • Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

    Basheer F, Giotopoulos G, Meduri E, Yun H, Mazan M et al.

    The Journal of experimental medicine 2019;216;4;966-981

  • Prioritization of cancer therapeutic targets using CRISPR-Cas9 screens.

    Behan FM, Iorio F, Picco G, Gonçalves E, Beaver CM et al.

    Nature 2019;568;7753;511-516

  • Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

    Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H et al.

    Cancer cell 2019;35;3;441-456.e8

  • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

    Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC et al.

    Cell 2019;176;6;1282-1294.e20

  • The circular RNome of primary breast cancer.

    Smid M, Wilting SM, Uhr K, Rodríguez-González FG, de Weerd V et al.

    Genome research 2019;29;3;356-366

  • A lentiviral vector-based insertional mutagenesis screen identifies mechanisms of resistance to MAPK inhibitors in melanoma.

    Ranzani M, Alifrangis C, Thompson NA, Rust AG, Allahyar A et al.

    Pigment cell & melanoma research 2019;32;2;332-335

  • Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

    Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D et al.

    Nature medicine 2019;25;3;517-525

  • JACKS: joint analysis of CRISPR/Cas9 knockout screens.

    Allen F, Behan F, Khodak A, Iorio F, Yusa K et al.

    Genome research 2019;29;3;464-471

  • Structural rearrangements generate cell-specific, gene-independent CRISPR-Cas9 loss of fitness effects.

    Gonçalves E, Behan FM, Louzada S, Arnol D, Stronach EA et al.

    Genome biology 2019;20;1;27

  • Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

    Collord G, Martincorena I, Young MD, Foroni L, Bolli N et al.

    British journal of haematology 2019;184;4;676-679

  • TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

    Haase D, Stevenson KE, Neuberg D, Maciejewski JP, Nazha A et al.

    Leukemia 2019

  • Cell Model Passports-a hub for clinical, genetic and functional datasets of preclinical cancer models.

    van der Meer D, Barthorpe S, Yang W, Lightfoot H, Hall C et al.

    Nucleic acids research 2019;47;D1;D923-D929

  • COSMIC: the Catalogue Of Somatic Mutations In Cancer.

    Tate JG, Bamford S, Jubb HC, Sondka Z, Beare DM et al.

    Nucleic acids research 2019;47;D1;D941-D947

  • Drug Sensitivity Assays of Human Cancer Organoid Cultures.

    Francies HE, Barthorpe A, McLaren-Douglas A, Barendt WJ and Garnett MJ

    Methods in molecular biology (Clifton, N.J.) 2019;1576;339-351

  • NOTCH1 Represses MCL-1 Levels in GSI-resistant T-ALL, Making them Susceptible to ABT-263.

    Dastur A, Choi A, Costa C, Yin X, Williams A et al.

    Clinical cancer research : an official journal of the American Association for Cancer Research 2019;25;1;312-324

  • CellMinerCDB for Integrative Cross-Database Genomics and Pharmacogenomics Analyses of Cancer Cell Lines.

    Rajapakse VN, Luna A, Yamade M, Loman L, Varma S et al.

    iScience 2018;10;247-264

  • Single cell analysis of clonal architecture in acute myeloid leukaemia.

    Potter N, Miraki-Moud F, Ermini L, Titley I, Vijayaraghavan G et al.

    Leukemia 2018

  • Neutral tumor evolution?

    Tarabichi M, Martincorena I, Gerstung M, Leroi AM, Markowetz F et al.

    Nature genetics 2018;50;12;1630-1633

  • Somatic mutant clones colonize the human esophagus with age.

    Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F et al.

    Science (New York, N.Y.) 2018;362;6417;911-917

  • Integrative Molecular Characterization of Malignant Pleural Mesothelioma.

    Hmeljak J, Sanchez-Vega F, Hoadley KA, Shih J, Stewart C et al.

    Cancer discovery 2018

  • Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

    Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N et al.

    The New England journal of medicine 2018;379;15;1416-1430

  • The genomic landscape of cutaneous SCC reveals drivers and a novel azathioprine associated mutational signature.

    Inman GJ, Wang J, Nagano A, Alexandrov LB, Purdie KJ et al.

    Nature communications 2018;9;1;3667

  • Population dynamics of normal human blood inferred from somatic mutations.

    Lee-Six H, Øbro NF, Shepherd MS, Grossmann S, Dawson K et al.

    Nature 2018;561;7724;473-478

  • Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

    Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A et al.

    Science (New York, N.Y.) 2018;361;6405

  • Circulating tumor DNA in patients with colorectal adenomas: assessment of detectability and genetic heterogeneity.

    Myint NNM, Verma AM, Fernandez-Garcia D, Sarmah P, Tarpey PS et al.

    Cell death & disease 2018;9;9;894

  • Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.

    Godfrey AL, Campbell PJ, MacLean C, Buck G, Cook J et al.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018;JCO2018788414

  • The germline genetic component of drug sensitivity in cancer cell lines.

    Menden MP, Casale FP, Stephan J, Bignell GR, Iorio F et al.

    Nature communications 2018;9;1;3385

  • Genomic patterns of progression in smoldering multiple myeloma.

    Bolli N, Maura F, Minvielle S, Gloznik D, Szalat R et al.

    Nature communications 2018;9;1;3363

  • Unsupervised correction of gene-independent cell responses to CRISPR-Cas9 targeting.

    Iorio F, Behan FM, Gonçalves E, Bhosle SG, Chen E et al.

    BMC genomics 2018;19;1;604

  • Organoid cultures recapitulate esophageal adenocarcinoma heterogeneity providing a model for clonality studies and precision therapeutics.

    Li X, Francies HE, Secrier M, Perner J, Miremadi A et al.

    Nature communications 2018;9;1;2983

  • Prediction of acute myeloid leukaemia risk in healthy individuals.

    Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N et al.

    Nature 2018;559;7714;400-404

  • Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

    Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ et al.

    Nature communications 2018;9;1;2378

  • Recurrent rearrangements of FOS and FOSB define osteoblastoma.

    Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC et al.

    Nature communications 2018;9;1;2150

  • Itraconazole targets cell cycle heterogeneity in colorectal cancer.

    Buczacki SJA, Popova S, Biggs E, Koukorava C, Buzzelli J et al.

    The Journal of experimental medicine 2018

  • Sequencing of prostate cancers identifies new cancer genes, routes of progression and drug targets.

    Wedge DC, Gundem G, Mitchell T, Woodcock DJ, Martincorena I et al.

    Nature genetics 2018;50;5;682-692

  • Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

    Turajlic S, Xu H, Litchfield K, Rowan A, Horswell S et al.

    Cell 2018;173;3;595-610.e11

  • Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

    Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR et al.

    Cell 2018;173;3;611-623.e17

  • Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers.

    Meier B, Volkova NV, Hong Y, Schofield P, Campbell PJ et al.

    Genome research 2018

  • The Origins and Vulnerabilities of Two Transmissible Cancers in Tasmanian Devils.

    Stammnitz MR, Coorens THH, Gori KC, Hayes D, Fu B et al.

    Cancer cell 2018;33;4;607-619.e15

  • Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.

    Maura F, Petljak M, Lionetti M, Cifola I, Liang W et al.

    Leukemia 2018;32;4;1044-1048

  • Intra-tumour diversification in colorectal cancer at the single-cell level.

    Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB et al.

    Nature 2018;556;7702;457-462

  • SvABA: genome-wide detection of structural variants and indels by local assembly.

    Wala JA, Bandopadhayay P, Greenwald NF, O'Rourke R, Sharpe T et al.

    Genome research 2018;28;4;581-591

  • Transcription Factor Activities Enhance Markers of Drug Sensitivity in Cancer.

    Garcia-Alonso L, Iorio F, Matchan A, Fonseca N, Jaaks P et al.

    Cancer research 2018;78;3;769-780

  • A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.

    León-Ortiz AM, Panier S, Sarek G, Vannier JB, Patel H et al.

    Molecular cell 2018;69;2;292-305.e6

  • Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells.

    Garaycoechea JI, Crossan GP, Langevin F, Mulderrig L, Louzada S et al.

    Nature 2018;553;7687;171-177

  • The European Society for Medical Oncology (ESMO) Precision Medicine Glossary.

    Yates LR, Seoane J, Le Tourneau C, Siu LL, Marais R et al.

    Annals of oncology : official journal of the European Society for Medical Oncology 2018;29;1;30-35

  • Comprehensive Pharmacogenomic Profiling of Malignant Pleural Mesothelioma Identifies a Subgroup Sensitive to FGFR Inhibition.

    Quispel-Janssen JM, Badhai J, Schunselaar L, Price S, Brammeld J et al.

    Clinical cancer research : an official journal of the American Association for Cancer Research 2018;24;1;84-94

  • Steps forward for cancer precision medicine.

    Salgado R, Moore H, Martens JWM, Lively T, Malik S et al.

    Nature reviews. Drug discovery 2017

  • Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.

    Prabhu VV, Talekar MK, Lulla AR, Kline CLB, Zhou L et al.

    Cell cycle (Georgetown, Tex.) 2017;1-29

  • Universal Patterns of Selection in Cancer and Somatic Tissues.

    Martincorena I, Raine KM, Gerstung M, Dawson KJ, Haase K et al.

    Cell 2017;171;5;1029-1041.e21

  • Short inverted repeats contribute to localized mutability in human somatic cells.

    Zou X, Morganella S, Glodzik D, Davies H, Li Y et al.

    Nucleic acids research 2017;45;19;11213-11221

  • Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

    Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ et al.

    Nature communications 2017;8;1;1221

  • The driver landscape of sporadic chordoma.

    Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB et al.

    Nature communications 2017;8;1;890

  • High-throughput RNAi screen for essential genes and drug synergistic combinations in colorectal cancer.

    Williams SP, Barthorpe AS, Lightfoot H, Garnett MJ and McDermott U

    Scientific data 2017;4;170139

  • Next-generation sequencing of a family with a high penetrance of monoclonal gammopathies for the identification of candidate risk alleles.

    Bolli N, Barcella M, Salvi E, D'Avila F, Vendramin A et al.

    Cancer 2017;123;19;3701-3708

  • Whole-Genome Sequencing Reveals Breast Cancers with Mismatch Repair Deficiency.

    Davies H, Morganella S, Purdie CA, Jang SJ, Borgen E et al.

    Cancer research 2017;77;18;4755-4762

  • Societal challenges of precision medicine: Bringing order to chaos.

    Salgado R, Moore H, Martens JWM, Lively T, Malik S et al.

    European journal of cancer (Oxford, England : 1990) 2017;84;325-334

  • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

    Roumeliotis TI, Williams SP, Gonçalves E, Alsinet C, Del Castillo Velasco-Herrera M et al.

    Cell reports 2017;20;9;2201-2214

  • Cliques and Schisms of Cancer Genes.

    Campbell PJ

    Cancer cell 2017;32;2;129-130

  • Genomic Evolution of Breast Cancer Metastasis and Relapse.

    Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S et al.

    Cancer cell 2017;32;2;169-184.e7

  • Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

    Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A et al.

    Cell reports 2017;20;3;572-585

  • The Pursuit of Therapeutic Biomarkers with High-Throughput Cancer Cell Drug Screens.

    Williams SP and McDermott U

    Cell chemical biology 2017

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Behjati S, Tarpey PS, Haase K, Ye H, Young MD et al.

    Nature communications 2017;8;15936

  • Drug Resistance Mechanisms in Colorectal Cancer Dissected with Cell Type-Specific Dynamic Logic Models.

    Eduati F, Doldàn-Martelli V, Klinger B, Cokelaer T, Sieber A et al.

    Cancer research 2017;77;12;3364-3375

  • A Road Map for Precision Cancer Medicine Using Personalized Models.

    Picco G and Garnett MJ

    Cancer discovery 2017;7;5;456-458

  • Molecular diagnoses of century-old childhood tumours.

    Virasami A, Farndon SJ, McDermott U, Sebire N and Behjati S

    The Lancet. Oncology 2017;18;5;e237

  • Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations.

    Brammeld JS, Petljak M, Martincorena I, Williams SP, Alonso LG et al.

    Genome research 2017;27;4;613-625

  • Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

    Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB et al.

    Nature 2017;543;7647;714-718

  • A somatic-mutational process recurrently duplicates germline susceptibility loci and tissue-specific super-enhancers in breast cancers.

    Glodzik D, Morganella S, Davies H, Simpson PT, Li Y et al.

    Nature genetics 2017;49;3;341-348

  • Precision oncology for acute myeloid leukemia using a knowledge bank approach.

    Gerstung M, Papaemmanuil E, Martincorena I, Bullinger L, Gaidzik VI et al.

    Nature genetics 2017;49;3;332-340

  • Revisiting olfactory receptors as putative drivers of cancer.

    Ranzani M, Iyer V, Ibarra-Soria X, Del Castillo Velasco-Herrera M, Garnett M et al.

    Wellcome open research 2017;2;9

  • COSMIC: somatic cancer genetics at high-resolution.

    Forbes SA, Beare D, Boutselakis H, Bamford S, Bindal N et al.

    Nucleic acids research 2017;45;D1;D777-D783

  • Sources of error in measurement of minimal residual disease in childhood acute lymphoblastic leukemia.

    Latham S, Hughes E, Budgen B, Mechinaud F, Crock C et al.

    PloS one 2017;12;10;e0185556

  • ascatNgs: Identifying Somatically Acquired Copy-Number Alterations from Whole-Genome Sequencing Data.

    Raine KM, Van Loo P, Wedge DC, Jones D, Menzies A et al.

    Current protocols in bioinformatics 2016;56;15.9.1-15.9.17

  • Logic models to predict continuous outputs based on binary inputs with an application to personalized cancer therapy.

    Knijnenburg TA, Klau GW, Iorio F, Garnett MJ, McDermott U et al.

    Scientific reports 2016;6;36812

  • Mutational signatures associated with tobacco smoking in human cancer.

    Alexandrov LB, Ju YS, Haase K, Van Loo P, Martincorena I et al.

    Science (New York, N.Y.) 2016;354;6312;618-622

  • RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features.

    Gaidzik VI, Teleanu V, Papaemmanuil E, Weber D, Paschka P et al.

    Leukemia 2016;30;11;2160-2168

  • A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns.

    Notta F, Chan-Seng-Yue M, Lemire M, Li Y, Wilson GW et al.

    Nature 2016;538;7625;378-382

  • A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia.

    Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E et al.

    Cell reports 2016;17;4;1193-1205

  • A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation.

    Kollmann K, Warsch W, Gonzalez-Arias C, Nice FL, Avezov E et al.

    Leukemia 2016

  • Tissue-specific mutation accumulation in human adult stem cells during life.

    Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S et al.

    Nature 2016;538;7624;260-264

  • COSMIC: High-Resolution Cancer Genetics Using the Catalogue of Somatic Mutations in Cancer.

    Forbes SA, Beare D, Bindal N, Bamford S, Ward S et al.

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