Vento-Tormo Group | Cellular Genetics

Vento-Tormo Group | Cellular Genetics

Vento-Tormo Group

Vento-Tormo Group at the Wellcome Sanger Institute
Vento-Tormo Group at the Wellcome Sanger Institute

Our Research and Approach

  • Immunogenomics - Immune responses against infection. Using genomics, imaging and computational tools, we seek to understand the checkpoint mechanisms that ensure tailored immune responses against different infections in distinct tissues. Our long-term goal is to understand the intracellular and extracellular mechanisms that shape the architecture of the immune response against infection.
  • Reproductive atlas - Reconstructing dynamic maps of reproductive organs. As part of the Developmental Atlas in partnership with the Human Cell atlas, we are seeking to produce a comprehensive 3D cellular map of the reproductive system.
  • Cellular networks - Cell-cell communication. We aim to create an interactome map that will help us understand the basic mechanisms of cellular responses and functions, by mapping all interactions between the receptors on cells' surfaces and the ligands they bind, along with their downstream signals. To acheive this we are developing new approaches using single-cell and spatial transcriptomic data.
Postdoctoral fellow positions

We encourage potential postdocs to apply for independent funding. We are happy to brainstorm ideas and help with the development of the proposal.

PhD positions

To apply for a PhD position in our group, please refer to the Wellcome Sanger Institute’s PhD Programme

More about the group's research

To find out more, please click on 'Read More' below.

Read More

People

Vento, Roser
Roser Vento-Tormo
Group Leader

Roser leads a research team at the Wellcome Sanger Institute.

Key Projects, Collaborations, Tools & Data

Research Programmes and Faciltites

Partners and Funders

Internal Partners

Publications

  • Single-cell reconstruction of the early maternal-fetal interface in humans.

    Vento-Tormo R, Efremova M, Botting RA, Turco MY, Vento-Tormo M et al.

    Nature 2018;563;7731;347-353

  • Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

    Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ et al.

    Science (New York, N.Y.) 2018;361;6402;594-599

  • Exponential scaling of single-cell RNA-seq in the past decade.

    Svensson V, Vento-Tormo R and Teichmann SA

    Nature protocols 2018;13;4;599-604

  • Prostaglandin E2 Leads to the Acquisition of DNMT3A-Dependent Tolerogenic Functions in Human Myeloid-Derived Suppressor Cells.

    Rodríguez-Ubreva J, Català-Moll F, Obermajer N, Álvarez-Errico D, Ramirez RN et al.

    Cell reports 2017;21;1;154-167

  • Genetic and Epigenetic Determinants in Autoinflammatory Diseases.

    Álvarez-Errico D, Vento-Tormo R and Ballestar E

    Frontiers in immunology 2017;8;318

  • DNA demethylation of inflammasome-associated genes is enhanced in patients with cryopyrin-associated periodic syndromes.

    Vento-Tormo R, Álvarez-Errico D, Garcia-Gomez A, Hernández-Rodríguez J, Buján S et al.

    The Journal of allergy and clinical immunology 2017;139;1;202-211.e6

  • IL-4 orchestrates STAT6-mediated DNA demethylation leading to dendritic cell differentiation.

    Vento-Tormo R, Company C, Rodríguez-Ubreva J, de la Rica L, Urquiza JM et al.

    Genome biology 2016;17;4

  • NF-κB-direct activation of microRNAs with repressive effects on monocyte-specific genes is critical for osteoclast differentiation.

    de la Rica L, García-Gómez A, Comet NR, Rodríguez-Ubreva J, Ciudad L et al.

    Genome biology 2015;16;2

  • Epigenetic control of myeloid cell differentiation, identity and function.

    Álvarez-Errico D, Vento-Tormo R, Sieweke M and Ballestar E

    Nature reviews. Immunology 2015;15;1;7-17

  • Gains of DNA methylation in myeloid terminal differentiation are dispensable for gene silencing but influence the differentiated phenotype.

    Vento-Tormo R, Álvarez-Errico D, Rodríguez-Ubreva J and Ballestar E

    The FEBS journal 2015;282;9;1815-25

  • NF-κB directly mediates epigenetic deregulation of common microRNAs in Epstein-Barr virus-mediated transformation of B-cells and in lymphomas.

    Vento-Tormo R, Rodríguez-Ubreva J, Lisio LD, Islam AB, Urquiza JM et al.

    Nucleic acids research 2014;42;17;11025-39