This page is maintained as a historical record and is no longer being updated.
In May 2019, the Sanger Institute made the difficult decision to close the animal facility, driven by its scientific strategy.
The Sanger Institute Research Support Facility (RSF) served the Institute and worldwide community by providing and caring for mice used in research studies. In conjunction with the RSF the Mouse Pipelines teams supported biomedical research through the humane and optimized use of genetically-modified mice. Under the most stringent care for the welfare of the animals, the mouse pipelines team generated, phenotyped, cryopreserved, and distributed new mouse strains to galvanize biomedical research.
The work of the Research Support Facility and Mouse Pipelines teams was underpinned by our Mouse Colony Management System (MCMS). This system was developed in-house by the Scientific Operations Mouse Informatics Team and enabled us to demonstrate, at the highest standards, our high levels of efficient production, colony management and archiving. The database was continually improved by the Mouse Informatics Team in conjunction with the Mouse Pipelines and Research Support Facility teams.
Mouse Genome Engineering
Model Pipelines produced and characterised knock-out mice for large-scale research projects, including the Sanger Mouse Genetics Project, KOMP2, EUCOMMTools, and the ...
Mouse Molecular Technologies
The team provided high-throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells or CRISPR/Cas9 ...
The Mouse Phenotyping team delivered phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompassed a standardised set ...
The Mouse Pipelines team supported biomedical research through the humane and optimized use of genetically-modified mice.