In May 2019, the Sanger Institute made the difficult decision to close the animal facility over the next few years, driven by its scientific strategy.
The Sanger Institute Research Support Facility (RSF) serves the Institute and worldwide community by providing and caring for mice used in research studies. In conjunction with the RSF the Mouse Pipelines teams support biomedical research through the humane and optimized use of genetically-modified mice. Under the most stringent care for the welfare of the animals, the mouse pipelines team generates, phenotypes, cryopreserves, and distributes new mouse strains to galvanize biomedical research.
The work of the Research Support Facility and Mouse Pipelines teams are underpinned by our Mouse Colony Management System (MCMS). This system was developed in-house by the Scientific Operations Mouse Informatics Team and enables us to demonstrate, at the highest standards, our high levels of efficient production, colony management and archiving. The database is continually improved by the Mouse Informatics Team in conjunction with the Mouse Pipelines and Research Support Facility teams.
Mouse Genome Engineering
Model Pipelines produce and characterise knock-out mice for large-scale research projects, including the Sanger Mouse Genetics Project, KOMP2, EUCOMMTools, and ...
Mouse Molecular Technologies
The team provides high-throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells or CRISPR/ ...
The Mouse Phenotyping team delivers phenotypic characterisation of mutant mice, typically knockouts of protein coding genes. Phenotyping encompasses a standardised ...
The Mouse Pipelines team supports biomedical research through the humane and optimized use of genetically-modified mice.