Soranzo Group | Human Complex Traits

Soranzo Group | Human Complex Traits

Soranzo Group

Our Research and Approach

Our research focuses on the application of large-scale genomic analysis to unravel the spectrum of human genetic variation associated with cardiometabolic diseases, and its interaction with non-genetic and environmental cues.

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Professor Nicole Soranzo
Group Leader

Nicole is the team leader. Nicole was trained in quantitative population and statistical genetics at the University of Milano, University of Dundee and University College London, where she applied genetic analysis to evolutionary studies of natural populations and human traits. She spent two years in the pharmaceutical industry in the US, applying human genetics to improve drug discovery and pharmacogenomics. She returned to the UK at the Sanger Institute, where she started her group in 2009. In 2013 she became adjunct faculty at the University of Cambridge School of Clinical Medicine, and in 2015 was awarded a personal chair in Human Genetics at the University of Cambridge School of Clinical Medicine in October 2015.

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Yan, Ying

Yan, Ying
Dr Ying Yan
Former Senior Bioinformatician at the Sanger Institute

Key Projects, Collaborations, Tools & Data

We strongly believe in the value of open data sharing, and have developed a number of tools and resources to facilitate access of our results by the scientific community.

Programmes, Associate Research Programmes and Facilities

Partners and Funders

Internal Partners
External Partners and Funders


  • The influence of rare variants in circulating metabolic biomarkers.

    Riveros-Mckay F, Oliver-Williams C, Karthikeyan S, Walter K, Kundu K et al.

    PLoS genetics 2020;16;3;e1008605

  • A brief history of human disease genetics.

    Claussnitzer M, Cho JH, Collins R, Cox NJ, Dermitzakis ET et al.

    Nature 2020;577;7789;179-189

  • A bird's-eye view of Italian genomic variation through whole-genome sequencing.

    Cocca M, Barbieri C, Concas MP, Robino A, Brumat M et al.

    European journal of human genetics : EJHG 2019

  • Genome-wide association study of eosinophilic granulomatosis with polyangiitis reveals genomic loci stratified by ANCA status.

    Lyons PA, Peters JE, Alberici F, Liley J, Coulson RMR et al.

    Nature communications 2019;10;1;5120

  • Uganda Genome Resource Enables Insights into Population History and Genomic Discovery in Africa.

    Gurdasani D, Carstensen T, Fatumo S, Chen G, Franklin CS et al.

    Cell 2019;179;4;984-1002.e36

  • The impact of donor and recipient common clinical and genetic variation on estimated glomerular filtration rate in a European renal transplant population.

    Stapleton CP, Heinzel A, Guan W, van der Most PJ, van Setten J et al.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2019;19;8;2262-2273

  • A catalog of genetic loci associated with kidney function from analyses of a million individuals.

    Wuttke M, Li Y, Li M, Sieber KB, Feitosa MF et al.

    Nature genetics 2019;51;6;957-972

  • Resolving variant-to-function relationships in hematopoiesis.

    Tardaguila M and Soranzo N

    Nature genetics 2019;51;4;581-583

  • Disentangling the genetics of lean mass.

    Karasik D, Zillikens MC, Hsu YH, Aghdassi A, Akesson K et al.

    The American journal of clinical nutrition 2019;109;2;276-287

  • GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals.

    Iotchkova V, Ritchie GRS, Geihs M, Morganella S, Min JL et al.

    Nature genetics 2019;51;2;343-353

  • Genome-wide analyses identify a role for SLC17A4 and AADAT in thyroid hormone regulation.

    Teumer A, Chaker L, Groeneweg S, Li Y, Di Munno C et al.

    Nature communications 2018;9;1;4455

  • Automated typing of red blood cell and platelet antigens: a whole-genome sequencing study.

    Lane WJ, Westhoff CM, Gleadall NS, Aguad M, Smeland-Wagman R et al.

    The Lancet. Haematology 2018;5;6;e241-e251

  • Genomic atlas of the human plasma proteome.

    Sun BB, Maranville JC, Peters JE, Stacey D, Staley JR et al.

    Nature 2018;558;7708;73-79

  • Long- and short-term outcomes in renal allografts with deceased donors: A large recipient and donor genome-wide association study.

    Hernandez-Fuentes MP, Franklin C, Rebollo-Mesa I, Mollon J, Delaney F et al.

    American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2018;18;6;1370-1379

  • Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.

    Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L et al.

    Nature communications 2018;9;1;1416

  • Heritable contributions versus genetic architecture.

    Timpson NJ, Greenwood CMT, Soranzo N, Lawson DJ and Richards JB

    Nature reviews. Genetics 2018;19;3;185

  • Genetic architecture: the shape of the genetic contribution to human traits and disease.

    Timpson NJ, Greenwood CMT, Soranzo N, Lawson DJ and Richards JB

    Nature reviews. Genetics 2018;19;2;110-124

  • Enrichment of low-frequency functional variants revealed by whole-genome sequencing of multiple isolated European populations.

    Xue Y, Mezzavilla M, Haber M, McCarthy S, Chen Y et al.

    Nature communications 2017;8;15927

  • Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

    Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J et al.

    American journal of human genetics 2017;100;6;865-884

  • The impact of rare and low-frequency genetic variants in common disease.

    Bomba L, Walter K and Soranzo N

    Genome biology 2017;18;1;77

  • Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.

    Ecker S, Chen L, Pancaldi V, Bagger FO, Fernández JM et al.

    Genome biology 2017;18;1;18

  • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.

    Astle WJ, Elding H, Jiang T, Allen D, Ruklisa D et al.

    Cell 2016;167;5;1415-1429.e19

  • Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.

    Chen L, Ge B, Casale FP, Vasquez L, Kwan T et al.

    Cell 2016;167;5;1398-1414.e24

  • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps.

    Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C et al.

    Nature genetics 2016;48;11;1303-1312

  • A reference panel of 64,976 haplotypes for genotype imputation.

    McCarthy S, Das S, Kretzschmar W, Delaneau O, Wood AR et al.

    Nature genetics 2016;48;10;1279-83

  • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

    Surendran P, Drenos F, Young R, Warren H, Cook JP et al.

    Nature genetics 2016;48;10;1151-61

  • Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis.

    Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R et al.

    American journal of human genetics 2016;99;2;481-8

  • Large-scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.

    Moreau T, Evans AL, Vasquez L, Tijssen MR, Yan Y et al.

    Nature communications 2016;7;11208

  • A multiple-phenotype imputation method for genetic studies.

    Dahl A, Iotchkova V, Baud A, Johansson Å, Gyllensten U et al.

    Nature genetics 2016;48;4;466-72

  • Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes.

    Teumer A, Tin A, Sorice R, Gorski M, Yeo NC et al.

    Diabetes 2016;65;3;803-17

  • Significant impact of miRNA-target gene networks on genetics of human complex traits.

    Okada Y, Muramatsu T, Suita N, Kanai M, Kawakami E et al.

    Scientific reports 2016;6;22223

  • Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function.

    Pattaro C, Teumer A, Gorski M, Chu AY, Li M et al.

    Nature communications 2016;7;10023

  • From GWAS to function: lessons from blood cells.

    Vasquez LJ, Mann AL, Chen L and Soranzo N

    ISBT science series 2016;11;Suppl Suppl 1;211-219

  • Genetic Influences on Metabolite Levels: A Comparison across Metabolomic Platforms.

    Yet I, Menni C, Shin SY, Mangino M, Soranzo N et al.

    PloS one 2016;11;4;e0153672

  • An interactive genome browser of association results from the UK10K cohorts project.

    Geihs M, Yan Y, Walter K, Huang J, Memari Y et al.

    Bioinformatics (Oxford, England) 2015;31;24;4029-31

  • Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci.

    Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R et al.

    Nature genetics 2015;47;12;1415-25

  • Genome sequencing elucidates Sardinian genetic architecture and augments association analyses for lipid and blood inflammatory markers.

    Sidore C, Busonero F, Maschio A, Porcu E, Naitza S et al.

    Nature genetics 2015;47;11;1272-81

  • The UK10K project identifies rare variants in health and disease.

    UK10K Consortium, Walter K, Min JL, Huang J, Crooks L et al.

    Nature 2015;526;7571;82-90

  • Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.

    Yang J, Bakshi A, Zhu Z, Hemani G, Vinkhuyzen AA et al.

    Nature genetics 2015;47;10;1114-20

  • Human genomics: The end of the start for population sequencing.

    Birney E and Soranzo N

    Nature 2015;526;7571;52-3

  • Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.

    Zheng HF, Forgetta V, Hsu YH, Estrada K, Rosello-Diez A et al.

    Nature 2015;526;7571;112-7

  • Height-reducing variants and selection for short stature in Sardinia.

    Zoledziewska M, Sidore C, Chiang CW, Sanna S, Mulas A et al.

    Nature genetics 2015

  • Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel.

    Huang J, Howie B, McCarthy S, Memari Y, Walter K et al.

    Nature communications 2015;6;8111

  • MultiMeta: an R package for meta-analyzing multi-phenotype genome-wide association studies.

    Vuckovic D, Gasparini P, Soranzo N and Iotchkova V

    Bioinformatics (Oxford, England) 2015;31;16;2754-6

  • Multicohort analysis of the maternal age effect on recombination.

    Martin HC, Christ R, Hussin JG, O'Connell J, Gordon S et al.

    Nature communications 2015;6;7846

  • Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate.

    Menni C, Graham D, Kastenmüller G, Alharbi NH, Alsanosi SM et al.

    Hypertension (Dallas, Tex. : 1979) 2015;66;2;422-9

  • Directional dominance on stature and cognition in diverse human populations.

    Joshi PK, Esko T, Mattsson H, Eklund N, Gandin I et al.

    Nature 2015;523;7561;459-462

  • Nonadditive Effects of Genes in Human Metabolomics.

    Tsepilov YA, Shin SY, Soranzo N, Spector TD, Prehn C et al.

    Genetics 2015;200;3;707-18

  • Characterization of functional methylomes by next-generation capture sequencing identifies novel disease-associated variants.

    Allum F, Shao X, Guénard F, Simon MM, Busche S et al.

    Nature communications 2015;6;7211

  • Whole-genome sequence-based analysis of thyroid function.

    Taylor PN, Porcu E, Chew S, Campbell PJ, Traglia M et al.

    Nature communications 2015;6;5681

  • Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

    Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H et al.

    Nature communications 2015;6;5897

  • Modulation of genetic associations with serum urate levels by body-mass-index in humans.

    Huffman JE, Albrecht E, Teumer A, Mangino M, Kapur K et al.

    PloS one 2015;10;3;e0119752

  • Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses.

    Ried JS, Shin SY, Krumsiek J, Illig T, Theis FJ et al.

    Human molecular genetics 2014;23;21;5847-57

  • A genome-wide association study of anorexia nervosa.

    Boraska V, Franklin CS, Floyd JA, Thornton LM, Huckins LM et al.

    Molecular psychiatry 2014;19;10;1085-94

  • Transcriptional diversity during lineage commitment of human blood progenitors.

    Chen L, Kostadima M, Martens JHA, Canu G, Garcia SP et al.

    Science (New York, N.Y.) 2014;345;6204;1251033

  • A rare variant in APOC3 is associated with plasma triglyceride and VLDL levels in Europeans.

    Timpson NJ, Walter K, Min JL, Tachmazidou I, Malerba G et al.

    Nature communications 2014;5;4871

  • A loss of function screen of identified genome-wide association study Loci reveals new genes controlling hematopoiesis.

    Bielczyk-Maczyńska E, Serbanovic-Canic J, Ferreira L, Soranzo N, Stemple DL et al.

    PLoS genetics 2014;10;7;e1004450

  • An atlas of genetic influences on human blood metabolites.

    Shin SY, Fauman EB, Petersen AK, Krumsiek J, Santos R et al.

    Nature genetics 2014;46;6;543-550

  • Genome-wide association study for circulating tissue plasminogen activator levels and functional follow-up implicates endothelial STXBP5 and STX2.

    Huang J, Huffman JE, Yamakuchi M, Yamkauchi M, Trompet S et al.

    Arteriosclerosis, thrombosis, and vascular biology 2014;34;5;1093-101

  • A general approach for haplotype phasing across the full spectrum of relatedness.

    O'Connell J, Gurdasani D, Delaneau O, Pirastu N, Ulivi S et al.

    PLoS genetics 2014;10;4;e1004234

  • Functional interpretation of non-coding sequence variation: concepts and challenges.

    Paul DS, Soranzo N and Beck S

    BioEssays : news and reviews in molecular, cellular and developmental biology 2014;36;2;191-9

  • Interrogating causal pathways linking genetic variants, small molecule metabolites, and circulating lipids.

    Shin SY, Petersen AK, Wahl S, Zhai G, Römisch-Margl W et al.

    Genome medicine 2014;6;3;25

  • Long term conservation of human metabolic phenotypes and link to heritability.

    Yousri NA, Kastenmüller G, Gieger C, Shin SY, Erte I et al.

    Metabolomics : Official journal of the Metabolomic Society 2014;10;5;1005-1017

  • Biomarkers for type 2 diabetes and impaired fasting glucose using a nontargeted metabolomics approach.

    Menni C, Fauman E, Erte I, Perry JR, Kastenmüller G et al.

    Diabetes 2013;62;12;4270-6

  • JAK2V617F leads to intrinsic changes in platelet formation and reactivity in a knock-in mouse model of essential thrombocythemia.

    Hobbs CM, Manning H, Bennett C, Vasquez L, Severin S et al.

    Blood 2013;122;23;3787-97

  • Platelet Genomics

    Bray,P.F., Jones,C.I., SORANZO,N. and Ouwehand,W.H.

    Platelets 2013

  • Maps of open chromatin highlight cell type-restricted patterns of regulatory sequence variation at hematological trait loci.

    Paul DS, Albers CA, Rendon A, Voss K, Stephens J et al.

    Genome research 2013;23;7;1130-41

  • Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.

    den Hoed M, Eijgelsheim M, Esko T, Brundel BJ, Peal DS et al.

    Nature genetics 2013;45;6;621-31

  • Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

    Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E et al.

    Nature genetics 2013;45;5;501-12

  • SMIM1 underlies the Vel blood group and influences red blood cell traits.

    Cvejic A, Haer-Wigman L, Stephens JC, Kostadima M, Smethurst PA et al.

    Nature genetics 2013;45;5;542-545

  • Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.

    Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J et al.

    Nature genetics 2013;45;2;145-54

  • Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.

    Pistis G, Okonkwo SU, Traglia M, Sala C, Shin SY et al.

    PloS one 2013;8;7;e69206

  • Small effective population size and genetic homogeneity in the Val Borbera isolate.

    Colonna V, Pistis G, Bomba L, Mona S, Matullo G et al.

    European journal of human genetics : EJHG 2013;21;1;89-94

  • Seventy-five genetic loci influencing the human red blood cell.

    van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N et al.

    Nature 2012;492;7429;369-75

  • A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site.

    Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K et al.

    Blood 2012;120;24;4859-68

  • Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

    Huang J, Sabater-Lleal M, Asselbergs FW, Tregouet D, Shin SY et al.

    Blood 2012;120;24;4873-81

  • Copy number variation of the APC gene is associated with regulation of bone mineral density.

    Chew S, Dastani Z, Brown SJ, Lewis JR, Dudbridge F et al.

    Bone 2012;51;5;939-43

  • Genome-wide meta-analysis of common variant differences between men and women.

    Boraska V, Jerončić A, Colonna V, Southam L, Nyholt DR et al.

    Human molecular genetics 2012;21;21;4805-15

  • Mapping cis- and trans-regulatory effects across multiple tissues in twins.

    Grundberg E, Small KS, Hedman ÅK, Nica AC, Buil A et al.

    Nature genetics 2012;44;10;1084-9

  • Genetic determinants of variability in glycated hemoglobin (HbA(1c)) in humans: review of recent progress and prospects for use in diabetes care.

    Soranzo N

    Current diabetes reports 2011;11;6;562-9

  • New gene functions in megakaryopoiesis and platelet formation.

    Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E et al.

    Nature 2011;480;7376;201-8

  • Human metabolic individuality in biomedical and pharmaceutical research.

    Suhre K, Shin SY, Petersen AK, Mohney RP, Meredith D et al.

    Nature 2011;477;7362;54-60

  • Maps of open chromatin guide the functional follow-up of genome-wide association signals: application to hematological traits.

    Paul DS, Nisbet JP, Yang TP, Meacham S, Rendon A et al.

    PLoS genetics 2011;7;6;e1002139

  • Common variants at 10 genomic loci influence hemoglobin A₁(C) levels via glycemic and nonglycemic pathways.

    Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D et al.

    Diabetes 2010;59;12;3229-39

  • Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

    Elks CE, Perry JR, Sulem P, Chasman DI, Franceschini N et al.

    Nature genetics 2010;42;12;1077-85

  • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.

    Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G et al.

    Nature genetics 2010;42;11;937-48

  • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.

    Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L et al.

    Nature genetics 2010;42;11;949-60

  • Hundreds of variants clustered in genomic loci and biological pathways affect human height.

    Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN et al.

    Nature 2010;467;7317;832-8

  • Integrating common and rare genetic variation in diverse human populations.

    International HapMap 3 Consortium, Altshuler DM, Gibbs RA, Peltonen L, Altshuler DM et al.

    Nature 2010;467;7311;52-8

  • Biological, clinical and population relevance of 95 loci for blood lipids.

    Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM et al.

    Nature 2010;466;7307;707-13

  • Genetic determinants of major blood lipids in Pakistanis compared with Europeans.

    Saleheen D, Soranzo N, Rasheed A, Scharnagl H, Gwilliam R et al.

    Circulation. Cardiovascular genetics 2010;3;4;348-57

  • Association of the 9p21.3 locus with risk of first-ever myocardial infarction in Pakistanis: case-control study in South Asia and updated meta-analysis of Europeans.

    Saleheen D, Alexander M, Rasheed A, Wormser D, Soranzo N et al.

    Arteriosclerosis, thrombosis, and vascular biology 2010;30;7;1467-73

  • Genetic loci influencing kidney function and chronic kidney disease.

    Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA et al.

    Nature genetics 2010;42;5;373-5

  • Common variants near TERC are associated with mean telomere length.

    Codd V, Mangino M, van der Harst P, Braund PS, Kaiser M et al.

    Nature genetics 2010;42;3;197-9

  • A genome-wide perspective of genetic variation in human metabolism.

    Illig T, Gieger C, Zhai G, Römisch-Margl W, Wang-Sattler R et al.

    Nature genetics 2010;42;2;137-41

  • New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.

    Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N et al.

    Nature genetics 2010;42;2;105-16

  • Genome-wide association study identifies five loci associated with lung function.

    Repapi E, Sayers I, Wain LV, Burton PR, Johnson T et al.

    Nature genetics 2010;42;1;36-44

  • A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

    Soranzo N, Spector TD, Mangino M, Kühnel B, Rendon A et al.

    Nature genetics 2009;41;11;1182-90

  • Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.

    Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV et al.

    Nature genetics 2009;41;11;1191-8

  • Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants?

    Southam L, Soranzo N, Montgomery SB, Frayling TM, McCarthy MI et al.

    Diabetologia 2009;52;9;1846-51

  • Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

    Falchi M, Bataille V, Hayward NK, Duffy DL, Bishop JA et al.

    Nature genetics 2009;41;8;915-9

  • Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.

    Nolte IM, Wallace C, Newhouse SJ, Waggott D, Fu J et al.

    PloS one 2009;4;7;e6138

  • Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.

    Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V et al.

    PLoS genetics 2009;5;6;e1000508

  • Genome-wide association study identifies eight loci associated with blood pressure.

    Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M et al.

    Nature genetics 2009;41;6;666-76

  • Loci at chromosomes 13, 19 and 20 influence age at natural menopause.

    Stolk L, Zhai G, van Meurs JB, Verbiest MM, Visser JA et al.

    Nature genetics 2009;41;6;645-7

  • Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.

    Perry JR, Stolk L, Franceschini N, Lunetta KL, Zhai G et al.

    Nature genetics 2009;41;6;648-50

  • Large scale association analysis of novel genetic loci for coronary artery disease.

    Coronary Artery Disease Consortium, Samani NJ, Deloukas P, Erdmann J, Hengstenberg C et al.

    Arteriosclerosis, thrombosis, and vascular biology 2009;29;5;774-80

  • A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.

    Soranzo N, Rendon A, Gieger C, Jones CI, Watkins NA et al.

    Blood 2009;113;16;3831-7

  • Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.

    Soranzo N, Rivadeneira F, Chinappen-Horsley U, Malkina I, Richards JB et al.

    PLoS genetics 2009;5;4;e1000445

  • A genome-wide association study identifies three loci associated with mean platelet volume.

    Meisinger C, Prokisch H, Gieger C, Soranzo N, Mehta D et al.

    American journal of human genetics 2009;84;1;66-71

  • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.

    Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM et al.

    Nature genetics 2009;41;1;25-34

  • Variants in MTNR1B influence fasting glucose levels.

    Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N et al.

    Nature genetics 2009;41;1;77-81

  • Male-pattern baldness susceptibility locus at 20p11.

    Richards JB, Yuan X, Geller F, Waterworth D, Bataille V et al.

    Nature genetics 2008;40;11;1282-4

  • Common variants near MC4R are associated with fat mass, weight and risk of obesity.

    Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH et al.

    Nature genetics 2008;40;6;768-75

  • Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.

    Richards JB, Rivadeneira F, Inouye M, Pastinen TM, Soranzo N et al.

    Lancet (London, England) 2008;371;9623;1505-12

  • Genome-wide association analysis identifies 20 loci that influence adult height.

    Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM et al.

    Nature genetics 2008;40;5;575-83