DNA Pipelines Research and Development | DNA Pipelines Development

DNA Pipelines Research and Development | DNA Pipelines Development

DNA Pipelines Research and Development

rd-9.jpgSanger Institute, Genome Research Limited
Research and Development

Our Research and Approach

The DNA Pipelines Research and Development group is the entry point for new technologies to the Institute, especially sequencing instruments. The team develops new methods and procedures to maximise the efficiency, quality and throughput of all incoming machinery for the benefit all Institute researchers.

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Cox, Tony
Dr Tony Cox
Group Leader
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Key Projects, Collaborations, Tools & Data

Programmes, Associate Research Programmes and Facilities

Partners and Funders

Internal Partners


  • Improved protocols for the illumina genome analyzer sequencing system.

    Quail MA, Swerdlow H and Turner DJ

    Current protocols in human genetics 2009;Chapter 18;Unit 18.2

  • Leukemia-associated somatic mutations drive distinct patterns of age-related clonal hemopoiesis.

    McKerrell T, Park N, Moreno T, Grove CS, Ponstingl H et al.

    Cell reports 2015;10;8;1239-45

  • G&T-seq: parallel sequencing of single-cell genomes and transcriptomes.

    Macaulay IC, Haerty W, Kumar P, Li YI, Hu TX et al.

    Nature methods 2015;12;6;519-22

  • SASI-Seq: sample assurance Spike-Ins, and highly differentiating 384 barcoding for Illumina sequencing.

    Quail MA, Smith M, Jackson D, Leonard S, Skelly T et al.

    BMC genomics 2014;15;110

  • Direct sequencing of small genomes on the Pacific Biosciences RS without library preparation.

    Coupland P, Chandra T, Quail M, Reik W and Swerdlow H

    BioTechniques 2012;53;6;365-72

  • A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers.

    Quail MA, Smith M, Coupland P, Otto TD, Harris SR et al.

    BMC genomics 2012;13;341

  • Optimal enzymes for amplifying sequencing libraries.

    Quail MA, Otto TD, Gu Y, Harris SR, Skelly TF et al.

    Nature methods 2011;9;1;10-1

  • Optimizing Illumina next-generation sequencing library preparation for extremely AT-biased genomes.

    Oyola SO, Otto TD, Gu Y, Maslen G, Manske M et al.

    BMC genomics 2012;13;1

  • A large genome center's improvements to the Illumina sequencing system.

    Quail MA, Kozarewa I, Smith F, Scally A, Stephens PJ et al.

    Nature methods 2008;5;12;1005-10

  • Amplification-free Illumina sequencing-library preparation facilitates improved mapping and assembly of (G+C)-biased genomes.

    Kozarewa I, Ning Z, Quail MA, Sanders MJ, Berriman M and Turner DJ

    Nature methods 2009;6;4;291-5

  • FRT-seq: amplification-free, strand-specific transcriptome sequencing.

    Mamanova L, Andrews RM, James KD, Sheridan EM, Ellis PD et al.

    Nature methods 2010;7;2;130-2