Dr Lara Bossini-Castillo
This person is a member of Sanger Institute Alumni.
Lara is a Postdoctoral Fellow in the Trynka Lab. Lara’s research is focused in how human genetic variability shapes the control of the immune system and contributes to the onset of complex immune-related diseases. She is particularly interested in deciphering the functional meaning of the genetic polymorphisms that have been associated with autoimmune diseases in genome-wide association studies (GWAS).
I shifted towards immunogenomics after joining Prof. Javier Martín’s group (Granada, Spain) for PhD training in medical-population genetics with focus on complex immune traits. During my PhD, I studied the genetic basis of autoimmune diseases, with a particular emphasis on systemic sclerosis. In this period, I combined my background as a biologist and my training in immunology with my interests in informatics and addressed computationally driven research problems. I was a co-lead analyst in an Immunochip-based study in systemic sclerosis and several GWAS and GWAS follow-up studies in different diseases. These studies contributed to the identification of a number of genetic regions associated with autoimmune diseases.
As a Postdoctoral Fellow my main aim is to evolve from locus discovery towards identification of causal variants by using computational and functional genomics.