I am a bioinformatician exploring how inherited changes in DNA may predespose children to develop cancer or other genetic disorders.
Rashesh is a senior bioinformatician in the Rahbari group focusing on somatic mutations acquired overtime during aging. His current focus is on somatic mutations and clonal dynamics in normal Testes.
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Interested in what 'cellular rejuvenation' and Altos Labs are all about? Here's our latest look at reprogramming technology with Yamanaka factors.
https://www.technologyreview.com/2022/10/25/1061644/how-to-be-young-again/
How do the #genome, #epigenome & #transcriptome co-evolve in colorectal #cancer? In the 1st of 2 studies in @Nature we measure the contribution of #chromatin accessibility in #cancer #evolution. #genetics and #epigenetics interplay! #EPICC1 @trevoragraham
https://www.nature.com/articles/s41586-022-05202-1
How do the #genome, #epigenome and #transcriptome co-evolve in colorectal #cancer? In the second of two papers in @nature, we find gene expr is not strongly heritable & evaluate "driverness" of muts directly in patient tumours https://www.nature.com/articles/s41586-022-05311-x @AndreaSottoriva #EPICC2 1/7
