I am a bioinformatician exploring how inherited changes in DNA may predespose children to develop cancer or other genetic disorders.
Rashesh is a senior bioinformatician in the Rahbari group focusing on somatic mutations acquired overtime during aging. His current focus is on somatic mutations and clonal dynamics in normal Testes.
Connect with me on Twitter
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Interested in what 'cellular rejuvenation' and Altos Labs are all about? Here's our latest look at reprogramming technology with Yamanaka factors.
https://www.technologyreview.com/2022/10/25/1061644/how-to-be-young-again/
How do the #genome, #epigenome & #transcriptome co-evolve in colorectal #cancer? In the 1st of 2 studies in @Nature we measure the contribution of #chromatin accessibility in #cancer #evolution. #genetics and #epigenetics interplay! #EPICC1 @trevoragraham
https://www.nature.com/articles/s41586-022-05202-1
How do the #genome, #epigenome and #transcriptome co-evolve in colorectal #cancer? In the second of two papers in @nature, we find gene expr is not strongly heritable & evaluate "driverness" of muts directly in patient tumours https://www.nature.com/articles/s41586-022-05311-x @AndreaSottoriva #EPICC2 1/7
