Hemberg Group | Quantitative models of gene expression

Hemberg Group | Quantitative models of gene expression

Hemberg Group

Hemberg lab retreat 2016

Our Research and Approach

Although every cell in an organism contains the same DNA, there is a great variety of cell types (e.g. skin, muscle, kidney) due to the fact that different genes are being transcribed. The amount of transcripts, or RNA, made from a specific gene can be measured in the cell and is referred to as the expression level of the gene. Understanding how, why, when and where genes are turned on and off is crucial for understanding many biological processes, ranging from devlopment to a variety of diseases, including cancer and autism.

Recent technological advances have made it possible to analyze gene expression and other related properties in a high-throughput manner, and this has resulted in a wealth of data. However, the experimental data is typically large, high-dimensional and noisy. We are interested in developing computational methods that will make it possible to extract as much information as possible from the data.

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Hemberg, Martin
Dr Martin Hemberg, PhD
Group Leader

Martin Hemberg is a Career Development Fellow Group Leader and his research interests are centered around quantitative models of gene expression and gene regulation. He is particularly interested in stochastic models and analysis of single-cell data. Another line of research involves analyzing the role of non-coding transcripts and sequences.

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Key Projects, Collaborations, Tools & Data

We have developed (and are currently developing) a suite of tools for analyzing gene expression.

Programmes, Associate Research Programmes and Facilities

Partners and Funders

We are interested in working in close collaboration with experimentalists as it provides with direct access to the people who generated data and have a deep understanding of the underlying biology. This approach makes it easier for us to develop mathematical models and it also provides us with a better understanding of what type of computational tools are needed.Some of the people that we have worked with in the past or are currently working with are listed below.
Internal Partners