Davenport Group | Functional Genomics

Davenport Group | Functional Genomics

Davenport Group

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Our Research and Approach

We combine genomic analysis with clinical data to understand the underlying genetic reasons why some patients are able to overcome infections more quickly than others and why people respond differently to the same drug.

Through clinical and industry collaborations, we analyse gene expression datasets from cohorts of patients with inflammatory diseases such as sepsis and autoimmune diseases. The main aim is to identify gene expression signatures for predicting disease severity and treatment response as well as using expression quantitative trait locus (eQTL) mapping to understand the role of regulatory DNA in patient heterogeneity.

People

Davenport, Emma
Dr Emma Davenport
Group Leader

Emma Davenport's research focuses on integrating functional genomics and clinical data in order to understand how genetics contributes to the patient-to-patient heterogeneity in treatment response.

Research Programmes and Faciltites

Publications

  • Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial.

    Davenport EE, Amariuta T, Gutierrez-Arcelus M, Slowikowski K, Westra HJ et al.

    Genome biology 2018;19;1;168

  • Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

    Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC et al.

    American journal of respiratory and critical care medicine 2017;196;3;328-339

  • Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

    Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P et al.

    The Lancet. Respiratory medicine 2016;4;4;259-71

  • Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

    van Schouwenburg PA, Davenport EE, Kienzler AK, Marwah I, Wright B et al.

    Clinical immunology (Orlando, Fla.) 2015;160;2;301-14

  • Transcriptomic profiling facilitates classification of response to influenza challenge.

    Davenport EE, Antrobus RD, Lillie PJ, Gilbert S and Knight JC

    Journal of molecular medicine (Berlin, Germany) 2015;93;1;105-14

  • Discovering in vivo cytokine-eQTL interactions from a lupus clinical trial.

    Davenport EE, Amariuta T, Gutierrez-Arcelus M, Slowikowski K, Westra HJ et al.

    Genome biology 2018;19;1;168

  • A community approach to mortality prediction in sepsis via gene expression analysis.

    Sweeney TE, Perumal TM, Henao R, Nichols M, Howrylak JA et al.

    Nature communications 2018;9;1;694

  • Classification of patients with sepsis according to blood genomic endotype: a prospective cohort study.

    Scicluna BP, van Vught LA, Zwinderman AH, Wiewel MA, Davenport EE et al.

    The Lancet. Respiratory medicine 2017;5;10;816-826

  • Shared and Distinct Aspects of the Sepsis Transcriptomic Response to Fecal Peritonitis and Pneumonia.

    Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC et al.

    American journal of respiratory and critical care medicine 2017;196;3;328-339

  • Chronic mucocutaneous candidiasis: characterization of a family with STAT-1 gain-of-function and development of an ex-vivo assay for Th17 deficiency of diagnostic utility.

    Dhalla F, Fox H, Davenport EE, Sadler R, Anzilotti C et al.

    Clinical and experimental immunology 2016;184;2;216-27

  • Genomic landscape of the individual host response and outcomes in sepsis: a prospective cohort study.

    Davenport EE, Burnham KL, Radhakrishnan J, Humburg P, Hutton P et al.

    The Lancet. Respiratory medicine 2016;4;4;259-71

  • Application of whole genome and RNA sequencing to investigate the genomic landscape of common variable immunodeficiency disorders.

    van Schouwenburg PA, Davenport EE, Kienzler AK, Marwah I, Wright B et al.

    Clinical immunology (Orlando, Fla.) 2015;160;2;301-14

  • Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

    Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB et al.

    Nature genetics 2015;47;7;717-726

  • Genome-wide association study of survival from sepsis due to pneumonia: an observational cohort study.

    Rautanen A, Mills TC, Gordon AC, Hutton P, Steffens M et al.

    The Lancet. Respiratory medicine 2015;3;1;53-60

  • Transcriptomic profiling facilitates classification of response to influenza challenge.

    Davenport EE, Antrobus RD, Lillie PJ, Gilbert S and Knight JC

    Journal of molecular medicine (Berlin, Germany) 2015;93;1;105-14

  • A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance.

    Fairfax BP, Davenport EE, Makino S, Hill AV, Vannberg FO and Knight JC

    Journal of immunology (Baltimore, Md. : 1950) 2011;186;5;3058-65