Sophie Hoffman

PhD Student

I am a PhD student interested in leveraging computational genomics to improve women’s reproductive health.

My PhD work focuses on understanding how maternal gene expression and its genetic regulation change over the course of pregnancy, and how these processes can help us understand pregnancy complications. To do this, I analyze longitudinal RNA sequencing and genotyping data from over 1,000 pregnant individuals from the Pregnancy Outcome Prediction Study 2 (POPs2). Using longitudinal transcriptomic and eQTL approaches, I characterize dynamic changes in the maternal immune system across gestation.

My timeline

• Began PhD in Biological Science at the Wellcome Sanger Institute 

• Completed MS in Bioinformatics at the University of Michigan

• Completed BS in Life Science Informatics at the University of Michigan