Swee Hoe Ong

Principal Software Developer

Initially trained as a bench scientist, I have been a computational biologist for many years working in fields as diverse as small-molecule antiviral drug discovery, molecular diagnostic development, bacterial metagenomics and cancer genomics. I am most interested in research that can lead to better diagnostics and therapeutics.

Initially my role in the Virus Genomics group at the Sanger Institute was to make sense out of virus genomic sequence data, e.g. to understand the origins, diversity, transmission, and evolutionary dynamics of important viral infectious agents such as HIV, HCV, MERS-CoV et cetera. I looked after the in-house bioinformatics pipepline for large-scale de novo genome assembly, quality checking and classification of HIV-1 genomes for three major international collaborative projects: BEEHIVE (Bridging the Evolution and Epidemiology of HIV in Europe), ICONIC (Infection Response through Virus Genomics), and PANGEA (Phylogenetics and Networks for Generalised HIV Epidemics in Africa) which is funded by the Bill and Melinda Gates Foundation.

I moved to the Stem Cell Genetics group under the Cellular Genetics Programme in 2016, and I have been supporting the group on whole-genome CRISPR/Cas9 guide RNA library design and optimisation, and analysis of genome-scale CRISPR/Cas9 knockout genetic screening data.

In September 2017 I joined the Jones group to work on characterising mutations in the early stages of cancer evolution.

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