Dougan Group
Our Research and Approach
Background
Infectious diseases still pose a threat at a global and local level, particularly as disease agents can evolve so quickly. For example, bacteria such as Salmonella and Shigella cause intestinal infections that can have devastating consequences particularly in developing countries, but bacterial strains such as these can be resistant to almost all antibiotics.
New approaches are needed to treat bacterial infections, one of which is focusing on understanding the methods by which the body's natural systems fight off the tens of thousands of potentially pathogenic bacteria to which it is exposed in ordinary everyday life.
A complementary challenge is investigating how disease agents change to prevent human intervention. Understanding the molecular basis of infection could assist in attempts to develop vaccines and other therapies to protect against infections.
This information will be exploited towards developing methods of controlling infection, including vaccines and antibiotics, in the continuing fight against disease that is crucial for populations worldwide.
The team is also investigating the relationships between different members of the family of bacteria that cause typhoid, Salmonella Typhi, in order to explain their evolution, antibiotic resistance and transmission within the human population.
Finally the team is involved in a number of major high profile collaborations worldwide investigating methods for developing vaccines against typhoid, dysentery, malaria, and tuberculosis, all critically important diseases particularly in developing countries.
People
Alumni
Binter, Spela
Spela Binter
Ellison, Louise
Louise Ellison
Forbester, Jessica Louise
Miss Jessica Louise Forbester
Forrest, Sally
Sally Forrest
Klemm, Elizabeth
Elizabeth Klemm, PhD
Langat, Pinky
Pinky Langat
Mukhopadhyay, Subhankar
Subhankar Mukhopadhyay
Oude Munnink, Bas
Bas Oude Munnink
Phan, My
Dr My Phan
Smith, Sarah
Dr Sarah Smith
Watson, Simon
Simon Watson
Key Projects, Collaborations, Tools & Data
Research Programmes and Faciltites
Partners and Funders
Internal Partners
Publications
-
Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316;5824;608-11
PUBMED: 17463290; PMC: 2610435; DOI: 10.1126/science.1139253
-
A new stage, a new life: individual success in quitting smoking.
Social science & medicine (1982) 1991;33;12;1365-71
PUBMED: 1776050
-
A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi.
Molecular microbiology 2007;66;5;1207-18
PUBMED: 17976161; PMC: 2652032; DOI: 10.1111/j.1365-2958.2007.05995.x
-
The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children.
The Journal of clinical investigation 2008;118;4;1553-62
PUBMED: 18357343; PMC: 2268878; DOI: 10.1172/JCI33998
-
Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa.
Nature genetics 2012;44;11;1215-21
PUBMED: 23023330; PMC: 3491877; DOI: 10.1038/ng.2423
-
IFITM3 restricts the morbidity and mortality associated with influenza.
Nature 2012;484;7395;519-23
PUBMED: 22446628; PMC: 3648786; DOI: 10.1038/nature10921
-
Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.
PLoS pathogens 2012;8;10;e1002995
PUBMED: 23133377; PMC: 3486913; DOI: 10.1371/journal.ppat.1002995
-
Evidence for several waves of global transmission in the seventh cholera pandemic.
Nature 2011;477;7365;462-5
PUBMED: 21866102; PMC: 3736323; DOI: 10.1038/nature10392
-
Localization of ATPase activity in dendritic spines of the cerebral cortex.
Journal of neurocytology 1991;20;9;703-15
PUBMED: 1835734
-
Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance.
Nature genetics 2015;47;1;84-7
PUBMED: 25401300; DOI: 10.1038/ng.3147
-
Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution.
Nature genetics 2014;46;12;1321-6
PUBMED: 25383970; DOI: 10.1038/ng.3145
-
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife 2014;3
PUBMED: 25347065; PMC: 4241536; DOI: 10.7554/eLife.03180
-
Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi.
Emerging infectious diseases 2014;20;11;1957-9
PUBMED: 25340988; PMC: 4214322; DOI: 10.3201/eid2011.141175
-
Emergence of a new epidemic Neisseria meningitidis serogroup A Clone in the African meningitis belt: high-resolution picture of genomic changes that mediate immune evasion.
mBio 2014;5;5;e01974-14
PUBMED: 25336458; PMC: 4212839; DOI: 10.1128/mBio.01974-14
-
Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever.
Annual review of microbiology 2014;68;317-36
PUBMED: 25208300; DOI: 10.1146/annurev-micro-091313-103739
-
Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;33;12199-204
PUBMED: 25092320; PMC: 4143038; DOI: 10.1073/pnas.1411012111
-
Corrigendum: Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Nature communications 2015;6;6108
PUBMED: 25629801; PMC: 4317489; DOI: 10.1038/ncomms7108
-
Typhoid fever in Fiji: a reversible plague?
Tropical medicine & international health : TM & IH 2014;19;10;1284-92
PUBMED: 25066005; PMC: 4285329; DOI: 10.1111/tmi.12367
-
The population structure of Vibrio cholerae from the Chandigarh Region of Northern India.
PLoS neglected tropical diseases 2014;8;7;e2981
PUBMED: 25058483; PMC: 4109905; DOI: 10.1371/journal.pntd.0002981
-
The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.
Cell host & microbe 2014;15;6;729-740
PUBMED: 24922575; PMC: 4078075; DOI: 10.1016/j.chom.2014.05.009
-
Global dissemination of a multidrug resistant Escherichia coli clone.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;15;5694-9
PUBMED: 24706808; PMC: 3992628; DOI: 10.1073/pnas.1322678111
-
Antibacterial resistance in sub-Saharan Africa: an underestimated emergency.
Annals of the New York Academy of Sciences 2014;1323;43-55
PUBMED: 24628272; PMC: 4159419; DOI: 10.1111/nyas.12380
-
GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Science signaling 2019;12;562
PUBMED: 30600262; DOI: 10.1126/scisignal.aau9048
-
Emergence of dominant multidrug-resistant bacterial clades: Lessons from history and whole-genome sequencing.
Proceedings of the National Academy of Sciences of the United States of America 2018;115;51;12872-12877
PUBMED: 30559200; DOI: 10.1073/pnas.1717162115
-
Chemical Synergy between Ionophore PBT2 and Zinc Reverses Antibiotic Resistance.
mBio 2018;9;6
PUBMED: 30538186; DOI: 10.1128/mBio.02391-18
-
Genome-Wide Epigenetic and Transcriptomic Characterization of Human-Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids.
Cellular and molecular gastroenterology and hepatology 2018;7;2;285-288
PUBMED: 30704978; DOI: 10.1016/j.jcmgh.2018.10.008
-
A systematic review of antimicrobial resistance in Salmonella enterica serovar Typhi, the etiological agent of typhoid.
PLoS neglected tropical diseases 2018;12;10;e0006779
PUBMED: 30307935; DOI: 10.1371/journal.pntd.0006779
-
Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.
Proceedings of the National Academy of Sciences of the United States of America 2018;115;40;10118-10123
PUBMED: 30217896; PMC: 6176607; DOI: 10.1073/pnas.1811866115
-
Identification of novel adenovirus genotype 90 in children from Bangladesh.
Microbial genomics 2018
PUBMED: 30248001; DOI: 10.1099/mgen.0.000221
-
New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam.
mBio 2018;9;5
PUBMED: 30181247; DOI: 10.1128/mBio.01056-18
-
An investigation into the Omp85 protein BamK in hypervirulent Klebsiella pneumoniae, and its role in outer membrane biogenesis.
Molecular microbiology 2018;109;5;584-599
PUBMED: 29873128; DOI: 10.1111/mmi.13990
-
FusC, a member of the M16 protease family acquired by bacteria for iron piracy against plants.
PLoS biology 2018;16;8;e2006026
PUBMED: 30071011; DOI: 10.1371/journal.pbio.2006026
-
Point prevalence survey of carbapenemase-producing Enterobacteriaceae (CPE) and vancomycin-resistant enterococci (VRE) in adult inpatients in a University teaching hospital in the United Kingdom.
The Journal of hospital infection 2018
PUBMED: 29969691; DOI: 10.1016/j.jhin.2018.06.024
-
Clonal analysis of Salmonella-specific effector T cells reveals serovar-specific and cross-reactive T cell responses.
Nature immunology 2018
PUBMED: 29925993; DOI: 10.1038/s41590-018-0133-z
-
Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy.
PLoS neglected tropical diseases 2018;12;4;e0006408
PUBMED: 29684021; DOI: 10.1371/journal.pntd.0006408
-
PlasmidTron: assembling the cause of phenotypes and genotypes from NGS data.
Microbial genomics 2018
PUBMED: 29533742; PMC: 5885016; DOI: 10.1099/mgen.0.000164
-
Outer membrane vesicles from Neisseria gonorrhoeae target PorB to mitochondria and induce apoptosis.
PLoS pathogens 2018;14;3;e1006945
PUBMED: 29601598; PMC: 5877877; DOI: 10.1371/journal.ppat.1006945
-
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.
Nature genetics 2018;50;3;424-431
PUBMED: 29379200; DOI: 10.1038/s41588-018-0046-7
-
Emergence of an Extensively Drug-Resistant Salmonella enterica Serovar Typhi Clone Harboring a Promiscuous Plasmid Encoding Resistance to Fluoroquinolones and Third-Generation Cephalosporins.
mBio 2018;9;1
PUBMED: 29463654; PMC: 5821095; DOI: 10.1128/mBio.00105-18
-
Comparison of Salmonella enterica serovars Typhi and Typhimurium reveals typhoidal-specific responses to bile.
Infection and immunity 2017
PUBMED: 29229736; DOI: 10.1128/IAI.00490-17
-
DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.
Gut 2017
PUBMED: 29141958; DOI: 10.1136/gutjnl-2017-314817
-
Genomic history of the seventh pandemic of cholera in Africa.
Science (New York, N.Y.) 2017;358;6364;785-789
PUBMED: 29123067; DOI: 10.1126/science.aad5901
-
Integrated view of Vibrio cholerae in the Americas.
Science (New York, N.Y.) 2017;358;6364;789-793
PUBMED: 29123068; DOI: 10.1126/science.aao2136
-
Constraints on lateral gene transfer in promoting fimbrial usher protein diversity and function.
Open biology 2017;7;11
PUBMED: 29142104; DOI: 10.1098/rsob.170144
-
Phylogenetic Analysis of Klebsiella pneumoniae from Hospitalized Children, Pakistan.
Emerging infectious diseases 2017;23;11;1872-1875
PUBMED: 29048298; PMC: 5652443; DOI: 10.3201/eid2311.170833
-
Complete Genome Sequence of Serotype III Streptococcus agalactiae Sequence Type 17 Strain 874391.
Genome announcements 2017;5;42
PUBMED: 29051249; PMC: 5646402; DOI: 10.1128/genomeA.01107-17
-
Citrobacter rodentium Subverts ATP Flux and Cholesterol Homeostasis in Intestinal Epithelial Cells In Vivo.
Cell metabolism 2017
PUBMED: 28988824; DOI: 10.1016/j.cmet.2017.09.003
-
Identification and characterization of the novel colonization factor CS30 based on whole genome sequencing in enterotoxigenic Escherichia coli (ETEC).
Scientific reports 2017;7;1;12514
PUBMED: 28970563; DOI: 10.1038/s41598-017-12743-3
-
Preterm Infant-Associated Clostridium tertium, Clostridium cadaveris, and Clostridium paraputrificum Strains: Genomic and Evolutionary Insights.
Genome biology and evolution 2017;9;10;2707-2714
PUBMED: 29044436; DOI: 10.1093/gbe/evx210
-
Salmonella enterica serovar Typhi Producing CTX-M-15 Extended Spectrum β-Lactamase in the Democratic Republic of the Congo.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2017;65;7;1229-1231
PUBMED: 29136410; PMC: 5849100; DOI: 10.1093/cid/cix342
-
NBEAL2 is required for neutrophil and NK cell function and pathogen defense.
The Journal of clinical investigation 2017;127;9;3521-3526
PUBMED: 28783043; DOI: 10.1172/JCI91684
-
Role of sapA and yfgA in Susceptibility to Antibody-Mediated Complement-Dependent Killing and Virulence of Salmonella enterica Serovar Typhimurium.
Infection and immunity 2017;85;9
PUBMED: 28674031; PMC: 5563563; DOI: 10.1128/IAI.00419-17
-
The Typhoid Vaccine Acceleration Consortium (TyVAC): Vaccine effectiveness study designs: Accelerating the introduction of typhoid conjugate vaccines and reducing the global burden of enteric fever. Report from a meeting held on 26-27 October 2016, Oxford, UK.
Vaccine 2017
PUBMED: 28802757; DOI: 10.1016/j.vaccine.2017.08.001
-
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Nature genetics 2017
PUBMED: 28581500; DOI: 10.1038/ng.3878
-
Exploiting induced pluripotent stem cell-derived macrophages to unravel host factors influencing Chlamydia trachomatis pathogenesis.
Nature communications 2017;8;15013
PUBMED: 28440293; PMC: 5414054; DOI: 10.1038/ncomms15013
-
Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity.
The Journal of experimental medicine 2017;214;4;1111-1128
PUBMED: 28351984; PMC: 5379978; DOI: 10.1084/jem.20161382
-
Typhoid in Africa and vaccine deployment.
The Lancet. Global health 2017;5;3;e236-e237
PUBMED: 28193381; DOI: 10.1016/S2214-109X(17)30045-1
-
The Type III Secretion System Effector SptP of Salmonella enterica Serovar Typhi.
Journal of bacteriology 2017;199;4
PUBMED: 27920299; PMC: 5287405; DOI: 10.1128/JB.00647-16
-
Induction of Cell Cycle and NK Cell Responses by Live-Attenuated Oral Vaccines against Typhoid Fever.
Frontiers in immunology 2017;8;1276
PUBMED: 29075261; PMC: 5643418; DOI: 10.3389/fimmu.2017.01276
-
Combined immunodeficiency with severe inflammation and allergy caused by ARPC1B deficiency.
The Journal of allergy and clinical immunology 2016
PUBMED: 27965109; DOI: 10.1016/j.jaci.2016.09.061
-
Mitochondrial Protein Lipoylation and the 2-Oxoglutarate Dehydrogenase Complex Controls HIF1α Stability in Aerobic Conditions.
Cell metabolism 2016;24;5;740-752
PUBMED: 27923773; DOI: 10.1016/j.cmet.2016.09.015
-
New Approaches for Needed Vaccines: Bacteria
The Vaccine Book: Second Edition 2016;311-29
DOI: 10.1016/B978-0-12-802174-3.00016-3; URL: http://dx.doi.org/10.1016/B97...8-0-12-802174-3.00016-3
-
Single-cell RNA-seq identifies a PD-1hi ILC progenitor and defines its development pathway.
Nature 2016;539;7627;102-106
PUBMED: 27749818; DOI: 10.1038/nature20105
-
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
Cell reports 2016;17;3;653-659
PUBMED: 27732843; DOI: 10.1016/j.celrep.2016.09.050
-
An extended genotyping framework for Salmonella enterica serovar Typhi, the cause of human typhoid.
Nature communications 2016;7;12827
PUBMED: 27703135; DOI: 10.1038/ncomms12827
-
Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
Nature genetics 2016;48;10;1211-7
PUBMED: 27548315; PMC: 5047355; DOI: 10.1038/ng.3644
-
Retrospective Analysis of Serotype Switching of Vibrio cholerae O1 in a Cholera Endemic Region Shows It Is a Non-random Process.
PLoS neglected tropical diseases 2016;10;10;e0005044
PUBMED: 27706170; DOI: 10.1371/journal.pntd.0005044
-
C13orf31 (FAMIN) is a central regulator of immunometabolic function.
Nature immunology 2016;17;9;1046-56
PUBMED: 27478939; DOI: 10.1038/ni.3532
-
Molecular Surveillance Identifies Multiple Transmissions of Typhoid in West Africa.
PLoS neglected tropical diseases 2016;10;9;e0004781
PUBMED: 27657909; DOI: 10.1371/journal.pntd.0004781
-
Derivation of Intestinal Organoids from Human Induced Pluripotent Stem Cells for Use as an Infection System.
Methods in molecular biology (Clifton, N.J.) 2016
PUBMED: 27576565; DOI: 10.1007/7651_2016_7
-
Using a Human Challenge Model of Infection to Measure Vaccine Efficacy: A Randomised, Controlled Trial Comparing the Typhoid Vaccines M01ZH09 with Placebo and Ty21a.
PLoS neglected tropical diseases 2016;10;8;e0004926
PUBMED: 27533046; PMC: 4988630; DOI: 10.1371/journal.pntd.0004926
-
Binding of Plasmodium falciparum Merozoite Surface Proteins DBLMSP and DBLMSP2 to Human Immunoglobulin M Is Conserved among Broadly Diverged Sequence Variants.
The Journal of biological chemistry 2016;291;27;14285-99
PUBMED: 27226583; PMC: 4933183; DOI: 10.1074/jbc.M116.722074
-
Infection Susceptibility in Gastric Intrinsic Factor (Vitamin B12)-Defective Mice Is Subject to Maternal Influences.
mBio 2016;7;3
PUBMED: 27329747; PMC: 4916386; DOI: 10.1128/mBio.00830-16
-
Conserved Features in the Structure, Mechanism, and Biogenesis of the Inverse Autotransporter Protein Family.
Genome biology and evolution 2016;8;6;1690-705
PUBMED: 27190006; PMC: 4943183; DOI: 10.1093/gbe/evw112
-
Genetic dissection of mammalian ERAD through comparative haploid and CRISPR forward genetic screens.
Nature communications 2016;7;11786
PUBMED: 27283361; PMC: 4906395; DOI: 10.1038/ncomms11786
-
The Molecular and Spatial Epidemiology of Typhoid Fever in Rural Cambodia.
PLoS neglected tropical diseases 2016;10;6;e0004785
PUBMED: 27331909; DOI: 10.1371/journal.pntd.0004785
-
Interferon-driven alterations of the host's amino acid metabolism in the pathogenesis of typhoid fever.
The Journal of experimental medicine 2016;213;6;1061-77
PUBMED: 27217537; PMC: 4886356; DOI: 10.1084/jem.20151025
-
Advances in Understanding Bacterial Pathogenesis Gained from Whole-Genome Sequencing and Phylogenetics.
Cell host & microbe 2016;19;5;599-610
PUBMED: 27173928; DOI: 10.1016/j.chom.2016.04.015
-
Microevolution of Monophasic Salmonella Typhimurium during Epidemic, United Kingdom, 2005-2010.
Emerging infectious diseases 2016;22;4;617-24
PUBMED: 26982594; PMC: 4806966; DOI: 10.3201/eid2204.150531
-
T cell fate and clonality inference from single-cell transcriptomes.
Nature methods 2016;13;4;329-332
PUBMED: 26950746; PMC: 4835021; DOI: 10.1038/nmeth.3800
-
Phylogeny, resistome and mobile genetic elements of emergent OXA-48 and OXA-245 Klebsiella pneumoniae clones circulating in Spain.
The Journal of antimicrobial chemotherapy 2016;71;4;887-96
PUBMED: 26769896; PMC: 4790626; DOI: 10.1093/jac/dkv458
-
Emergence of host-adapted Salmonella Enteritidis through rapid evolution in an immunocompromised host.
Nature microbiology 2016;1;3
PUBMED: 27127642; PMC: 4843968; DOI: 10.1038/nmicrobiol.2015.23
-
A Phylogenetic and Phenotypic Analysis of Salmonella enterica Serovar Weltevreden, an Emerging Agent of Diarrheal Disease in Tropical Regions.
PLoS neglected tropical diseases 2016;10;2;e0004446
PUBMED: 26867150; PMC: 4750946; DOI: 10.1371/journal.pntd.0004446
-
Five decades of genome evolution in the globally distributed, extensively antibiotic-resistant Acinetobacter baumannii global clone 1.
Microbial genomics 2016;2;2;e000052
PUBMED: 28348844; PMC: 5320584; DOI: 10.1099/mgen.0.000052
-
Quantitative proteomic analysis of Shigella flexneri and Shigella sonnei Generalized Modules for Membrane Antigens (GMMA) reveals highly pure preparations.
International journal of medical microbiology : IJMM 2016;306;2;99-108
PUBMED: 26746581; PMC: 4820968; DOI: 10.1016/j.ijmm.2015.12.003
-
Invasive Group A Streptococcus Infection among Children, Rural Kenya.
Emerging infectious diseases 2016;22;2;224-32
PUBMED: 26811918; DOI: 10.3201/eid2202.151358
-
Evolution of atypical enteropathogenic E. coli by repeated acquisition of LEE pathogenicity island variants.
Nature microbiology 2016;1;15010
PUBMED: 27571974; DOI: 10.1038/nmicrobiol.2015.10
-
A novel ciprofloxacin-resistant subclade of H58 Salmonella Typhi is associated with fluoroquinolone treatment failure.
eLife 2016;5
PUBMED: 26974227; PMC: 4805543; DOI: 10.7554/eLife.14003
-
Discovery and Characterization of Human-Urine Utilization by Asymptomatic-Bacteriuria-Causing Streptococcus agalactiae.
Infection and immunity 2015;84;1;307-19
PUBMED: 26553467; PMC: 4694007; DOI: 10.1128/IAI.00938-15
-
Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.
Scientific reports 2015;5;12524
PUBMED: 26224331; PMC: 4519778; DOI: 10.1038/srep12524
-
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.
Infection and immunity 2015;83;7;2926-34
PUBMED: 25964470; PMC: 4468523; DOI: 10.1128/IAI.00161-15
-
GENE SILENCING. Epigenetic silencing by the HUSH complex mediates position-effect variegation in human cells.
Science (New York, N.Y.) 2015;348;6242;1481-5
PUBMED: 26022416; PMC: 4487827; DOI: 10.1126/science.aaa7227
-
Defining the Roles of TcdA and TcdB in Localized Gastrointestinal Disease, Systemic Organ Damage, and the Host Response during Clostridium difficile Infections.
mBio 2015;6;3;e00551
PUBMED: 26037121; PMC: 4453007; DOI: 10.1128/mBio.00551-15
-
The transcription factor Bcl11b is specifically expressed in group 2 innate lymphoid cells and is essential for their development.
The Journal of experimental medicine 2015;212;6;865-74
PUBMED: 25964371; PMC: 4451136; DOI: 10.1084/jem.20142318
-
Non-typhoidal Salmonella Typhimurium ST313 isolates that cause bacteremia in humans stimulate less inflammasome activation than ST19 isolates associated with gastroenteritis.
Pathogens and disease 2015;73;4
PUBMED: 25808600; PMC: 4399442; DOI: 10.1093/femspd/ftu023
-
Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease.
PLoS neglected tropical diseases 2015;9;6;e0003837
PUBMED: 26065687; PMC: 4465829; DOI: 10.1371/journal.pntd.0003837
-
Phylogeographical analysis of the dominant multidrug-resistant H58 clade of Salmonella Typhi identifies inter- and intracontinental transmission events.
Nature genetics 2015;47;6;632-9
PUBMED: 25961941; PMC: 4921243; DOI: 10.1038/ng.3281
-
Ceftriaxone-resistant Salmonella enterica serotype typhimurium sequence type 313 from Kenyan patients is associated with the blaCTX-M-15 gene on a novel IncHI2 plasmid.
Antimicrobial agents and chemotherapy 2015;59;6;3133-9
PUBMED: 25779570; PMC: 4432211; DOI: 10.1128/AAC.00078-15
-
Activation of Salmonella Typhi-specific regulatory T cells in typhoid disease in a wild-type S. Typhi challenge model.
PLoS pathogens 2015;11;5;e1004914
PUBMED: 26001081; PMC: 4441490; DOI: 10.1371/journal.ppat.1004914
-
Rapid emergence of multidrug resistant, H58-lineage Salmonella typhi in Blantyre, Malawi.
PLoS neglected tropical diseases 2015;9;4;e0003748
PUBMED: 25909750; PMC: 4409211; DOI: 10.1371/journal.pntd.0003748
-
Multidrug-resistant Salmonella enterica serotype Typhi, Gulf of Guinea Region, Africa.
Emerging infectious diseases 2015;21;4;655-9
PUBMED: 25811307; PMC: 4378479; DOI: 10.3201/eid2104.141355
-
Conditional-ready mouse embryonic stem cell derived macrophages enable the study of essential genes in macrophage function.
Scientific reports 2015;5;8908
PUBMED: 25752829; PMC: 4354151; DOI: 10.1038/srep08908
-
An O antigen capsule modulates bacterial pathogenesis in Shigella sonnei.
PLoS pathogens 2015;11;3;e1004749
PUBMED: 25794007; PMC: 4368438; DOI: 10.1371/journal.ppat.1004749
-
Signatures of adaptation in human invasive Salmonella Typhimurium ST313 populations from sub-Saharan Africa.
PLoS neglected tropical diseases 2015;9;3;e0003611
PUBMED: 25803844; PMC: 4372345; DOI: 10.1371/journal.pntd.0003611
-
The Hd, Hj, and Hz66 flagella variants of Salmonella enterica serovar Typhi modify host responses and cellular interactions.
Scientific reports 2015;5;7947
PUBMED: 25609312; PMC: 4302301; DOI: 10.1038/srep07947
-
Patterns of genome evolution that have accompanied host adaptation in Salmonella.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;3;863-8
PUBMED: 25535353; PMC: 4311825; DOI: 10.1073/pnas.1416707112
-
Emergence of scarlet fever Streptococcus pyogenes emm12 clones in Hong Kong is associated with toxin acquisition and multidrug resistance.
Nature genetics 2015;47;1;84-7
PUBMED: 25401300; DOI: 10.1038/ng.3147
-
Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.
PloS one 2015;10;5;e0124307
PUBMED: 25946027; PMC: 4422593; DOI: 10.1371/journal.pone.0124307
-
Transfer of scarlet fever-associated elements into the group A Streptococcus M1T1 clone.
Scientific reports 2015;5;15877
PUBMED: 26522788; PMC: 4629146; DOI: 10.1038/srep15877
-
Identification of enterotoxigenic Escherichia coli (ETEC) clades with long-term global distribution.
Nature genetics 2014;46;12;1321-6
PUBMED: 25383970; DOI: 10.1038/ng.3145
-
Drug resistance in Salmonella enterica ser. Typhimurium bloodstream infection, Malawi.
Emerging infectious diseases 2014;20;11;1957-9
PUBMED: 25340988; PMC: 4214322; DOI: 10.3201/eid2011.141175
-
CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.
eLife 2014;3
PUBMED: 25347065; PMC: 4241536; DOI: 10.7554/eLife.03180
-
Emergence of a new epidemic Neisseria meningitidis serogroup A Clone in the African meningitis belt: high-resolution picture of genomic changes that mediate immune evasion.
mBio 2014;5;5;e01974-14
PUBMED: 25336458; PMC: 4212839; DOI: 10.1128/mBio.01974-14
-
Epithelial IL-22RA1-mediated fucosylation promotes intestinal colonization resistance to an opportunistic pathogen.
Cell host & microbe 2014;16;4;504-16
PUBMED: 25263220; PMC: 4190086; DOI: 10.1016/j.chom.2014.08.017
-
Typhoid fever in Fiji: a reversible plague?
Tropical medicine & international health : TM & IH 2014;19;10;1284-92
PUBMED: 25066005; PMC: 4285329; DOI: 10.1111/tmi.12367
-
Antibacterial resistance in sub-Saharan Africa: an underestimated emergency.
Annals of the New York Academy of Sciences 2014;1323;43-55
PUBMED: 24628272; PMC: 4159419; DOI: 10.1111/nyas.12380
-
Transient Darwinian selection in Salmonella enterica serovar Paratyphi A during 450 years of global spread of enteric fever.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;33;12199-204
PUBMED: 25092320; PMC: 4143038; DOI: 10.1073/pnas.1411012111
-
TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;31;11425-30
PUBMED: 25030448; PMC: 4128144; DOI: 10.1073/pnas.1409099111
-
Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline.
Nature communications 2014;5;4544
PUBMED: 25088811; PMC: 4538795; DOI: 10.1038/ncomms5544
-
The population structure of Vibrio cholerae from the Chandigarh Region of Northern India.
PLoS neglected tropical diseases 2014;8;7;e2981
PUBMED: 25058483; PMC: 4109905; DOI: 10.1371/journal.pntd.0002981
-
Insertions in the OCL1 locus of Acinetobacter baumannii lead to shortened lipooligosaccharides.
Research in microbiology 2014;165;6;472-5
PUBMED: 24861001; PMC: 4110982; DOI: 10.1016/j.resmic.2014.05.034
-
Vitamin B₁₂-dependent taurine synthesis regulates growth and bone mass.
The Journal of clinical investigation 2014;124;7;2988-3002
PUBMED: 24911144; PMC: 4071367; DOI: 10.1172/JCI72606
-
The classical lancefield antigen of group a Streptococcus is a virulence determinant with implications for vaccine design.
Cell host & microbe 2014;15;6;729-740
PUBMED: 24922575; PMC: 4078075; DOI: 10.1016/j.chom.2014.05.009
-
Complete Genome Sequences of Two Citrobacter rodentium Bacteriophages, CR8 and CR44b.
Genome announcements 2014;2;3
PUBMED: 24874665; PMC: 4038870; DOI: 10.1128/genomeA.00146-14
-
An outpatient, ambulant-design, controlled human infection model using escalating doses of Salmonella Typhi challenge delivered in sodium bicarbonate solution.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014;58;9;1230-40
PUBMED: 24519873; PMC: 3982839; DOI: 10.1093/cid/ciu078
-
Global dissemination of a multidrug resistant Escherichia coli clone.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;15;5694-9
PUBMED: 24706808; PMC: 3992628; DOI: 10.1073/pnas.1322678111
-
Neutrophils recruited by IL-22 in peripheral tissues function as TRAIL-dependent antiviral effectors against MCMV.
Cell host & microbe 2014;15;4;471-83
PUBMED: 24721575; PMC: 3989063; DOI: 10.1016/j.chom.2014.03.003
-
Genome sequencing of disease and carriage isolates of nontypeable Haemophilus influenzae identifies discrete population structure.
Proceedings of the National Academy of Sciences of the United States of America 2014;111;14;5439-44
PUBMED: 24706866; PMC: 3986186; DOI: 10.1073/pnas.1403353111
-
A GC1 Acinetobacter baumannii isolate carrying AbaR3 and the aminoglycoside resistance transposon TnaphA6 in a conjugative plasmid.
The Journal of antimicrobial chemotherapy 2014;69;4;955-8
PUBMED: 24235096; PMC: 3956371; DOI: 10.1093/jac/dkt454
-
Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.
BMC genomics 2014;15;160
PUBMED: 24568651; PMC: 4028888; DOI: 10.1186/1471-2164-15-160
-
Identification of a marker for two lineages within the GC1 clone of Acinetobacter baumannii.
The Journal of antimicrobial chemotherapy 2014;69;2;557-8
PUBMED: 24080502; PMC: 3886933; DOI: 10.1093/jac/dkt379
-
Genomic epidemiology of Vibrio cholerae O1 associated with floods, Pakistan, 2010.
Emerging infectious diseases 2014;20;1;13-20
PUBMED: 24378019; PMC: 3884714; DOI: 10.3201/.eid2001.130428
-
Salmonella enterica serovar Typhi and the pathogenesis of typhoid fever.
Annual review of microbiology 2014;68;317-36
PUBMED: 25208300; DOI: 10.1146/annurev-micro-091313-103739
-
Tracking the establishment of local endemic populations of an emergent enteric pathogen.
Proceedings of the National Academy of Sciences of the United States of America 2013;110;43;17522-7
PUBMED: 24082120; PMC: 3808646; DOI: 10.1073/pnas.1308632110
-
Identification of Salmonella enterica serovar Typhi genotypes by use of rapid multiplex ligation-dependent probe amplification.
Journal of clinical microbiology 2013;51;9;2950-8
PUBMED: 23824765; PMC: 3754622; DOI: 10.1128/JCM.01010-13
-
The agr locus regulates virulence and colonization genes in Clostridium difficile 027.
Journal of bacteriology 2013;195;16;3672-81
PUBMED: 23772065; PMC: 3754575; DOI: 10.1128/JB.00473-13
-
Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes.
Cell 2013;154;2;452-64
PUBMED: 23870131; PMC: 3717207; DOI: 10.1016/j.cell.2013.06.022
-
Characterization of the yehUT two-component regulatory system of Salmonella enterica Serovar Typhi and Typhimurium.
PloS one 2013;8;12;e84567
PUBMED: 24386394; PMC: 3875573; DOI: 10.1371/journal.pone.0084567
-
Defining the range of pathogens susceptible to Ifitm3 restriction using a knockout mouse model.
PloS one 2013;8;11;e80723
PUBMED: 24278312; PMC: 3836756; DOI: 10.1371/journal.pone.0080723
-
Emergence and global spread of epidemic healthcare-associated Clostridium difficile.
Nature genetics 2013;45;1;109-13
PUBMED: 23222960; PMC: 3605770; DOI: 10.1038/ng.2478
-
Extensive diversity of Streptococcus pyogenes in a remote human population reflects global-scale transmission rather than localised diversification.
PloS one 2013;8;9;e73851
PUBMED: 24066079; PMC: 3774777; DOI: 10.1371/journal.pone.0073851
-
Haploid genetic screens identify an essential role for PLP2 in the downregulation of novel plasma membrane targets by viral E3 ubiquitin ligases.
PLoS pathogens 2013;9;11;e1003772
PUBMED: 24278019; PMC: 3836740; DOI: 10.1371/journal.ppat.1003772
-
Mcph1-deficient mice reveal a role for MCPH1 in otitis media.
PloS one 2013;8;3;e58156
PUBMED: 23516444; PMC: 3596415; DOI: 10.1371/journal.pone.0058156
-
RNA-seq reveals the RNA binding proteins, Hfq and RsmA, play various roles in virulence, antibiotic production and genomic flux in Serratia sp. ATCC 39006.
BMC genomics 2013;14;822
PUBMED: 24267595; PMC: 4046660; DOI: 10.1186/1471-2164-14-822
-
RocA truncation underpins hyper-encapsulation, carriage longevity and transmissibility of serotype M18 group A streptococci.
PLoS pathogens 2013;9;12;e1003842
PUBMED: 24367267; PMC: 3868526; DOI: 10.1371/journal.ppat.1003842
-
Intracontinental spread of human invasive Salmonella Typhimurium pathovariants in sub-Saharan Africa.
Nature genetics 2012;44;11;1215-21
PUBMED: 23023330; PMC: 3491877; DOI: 10.1038/ng.2423
-
Shigella sonnei genome sequencing and phylogenetic analysis indicate recent global dissemination from Europe.
Nature genetics 2012;44;9;1056-9
PUBMED: 22863732; PMC: 3442231; DOI: 10.1038/ng.2369
-
The Clostridium difficile spo0A gene is a persistence and transmission factor.
Infection and immunity 2012;80;8;2704-11
PUBMED: 22615253; PMC: 3434595; DOI: 10.1128/IAI.00147-12
-
Molecular characterization of the 2011 Hong Kong scarlet fever outbreak.
The Journal of infectious diseases 2012;206;3;341-51
PUBMED: 22615319; PMC: 4125623; DOI: 10.1093/infdis/jis362
-
The role of sphingosine-1-phosphate transporter Spns2 in immune system function.
Journal of immunology (Baltimore, Md. : 1950) 2012;189;1;102-11
PUBMED: 22664872; PMC: 3381845; DOI: 10.4049/jimmunol.1200282
-
A conserved acetyl esterase domain targets diverse bacteriophages to the Vi capsular receptor of Salmonella enterica serovar Typhi.
Journal of bacteriology 2010;192;21;5746-54
PUBMED: 20817773; PMC: 2953684; DOI: 10.1128/JB.00659-10
-
Legionella pneumophila strain 130b possesses a unique combination of type IV secretion systems and novel Dot/Icm secretion system effector proteins.
Journal of bacteriology 2010;192;22;6001-16
PUBMED: 20833813; PMC: 2976443; DOI: 10.1128/JB.00778-10
-
Use of purified Clostridium difficile spores to facilitate evaluation of health care disinfection regimens.
Applied and environmental microbiology 2010;76;20;6895-900
PUBMED: 20802075; PMC: 2953018; DOI: 10.1128/AEM.00718-10
-
Molecular and physiological analysis of three Pseudomonas aeruginosa phages belonging to the "N4-like viruses".
Virology 2010;405;1;26-30
PUBMED: 20619867; PMC: 3715699; DOI: 10.1016/j.virol.2010.06.011
-
An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin.
Vaccine 2010;28;33;5427-31
PUBMED: 20558246; PMC: 3764428; DOI: 10.1016/j.vaccine.2010.06.005
-
Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion.
Science (New York, N.Y.) 2010;329;5987;85-9
PUBMED: 20538915; PMC: 3628452; DOI: 10.1126/science.1188063
-
Typhoid in Kenya is associated with a dominant multidrug-resistant Salmonella enterica serovar Typhi haplotype that is also widespread in Southeast Asia.
Journal of clinical microbiology 2010;48;6;2171-6
PUBMED: 20392916; PMC: 2884483; DOI: 10.1128/JCM.01983-09
-
Dysregulated humoral immunity to nontyphoidal Salmonella in HIV-infected African adults.
Science (New York, N.Y.) 2010;328;5977;508-12
PUBMED: 20413503; DOI: 10.1126/science.1180346
-
Evolutionary dynamics of Clostridium difficile over short and long time scales.
Proceedings of the National Academy of Sciences of the United States of America 2010;107;16;7527-32
PUBMED: 20368420; PMC: 2867753; DOI: 10.1073/pnas.0914322107
-
The Citrobacter rodentium genome sequence reveals convergent evolution with human pathogenic Escherichia coli.
Journal of bacteriology 2010;192;2;525-38
PUBMED: 19897651; PMC: 2805327; DOI: 10.1128/JB.01144-09
-
Manual annotation and analysis of the defensin gene cluster in the C57BL/6J mouse reference genome.
BMC genomics 2009;10;606
PUBMED: 20003482; PMC: 2807441; DOI: 10.1186/1471-2164-10-606
-
A simple method for directional transcriptome sequencing using Illumina technology.
Nucleic acids research 2009;37;22;e148
PUBMED: 19815668; PMC: 2794173; DOI: 10.1093/nar/gkp811
-
Simultaneous assay of every Salmonella Typhi gene using one million transposon mutants.
Genome research 2009;19;12;2308-16
PUBMED: 19826075; PMC: 2792183; DOI: 10.1101/gr.097097.109
-
The T3SS effector EspT defines a new category of invasive enteropathogenic E. coli (EPEC) which form intracellular actin pedestals.
PLoS pathogens 2009;5;12;e1000683
PUBMED: 20011125; PMC: 2782363; DOI: 10.1371/journal.ppat.1000683
-
Antibiotic treatment of clostridium difficile carrier mice triggers a supershedder state, spore-mediated transmission, and severe disease in immunocompromised hosts.
Infection and immunity 2009;77;9;3661-9
PUBMED: 19564382; PMC: 2737984; DOI: 10.1128/IAI.00558-09
-
Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.
Journal of bacteriology 2009;191;17;5377-86
PUBMED: 19542279; PMC: 2725610; DOI: 10.1128/JB.00597-09
-
A strand-specific RNA-Seq analysis of the transcriptome of the typhoid bacillus Salmonella typhi.
PLoS genetics 2009;5;7;e1000569
PUBMED: 19609351; PMC: 2704369; DOI: 10.1371/journal.pgen.1000569
-
Public health. The cholera crisis in Africa.
Science (New York, N.Y.) 2009;324;5929;885
PUBMED: 19443768; DOI: 10.1126/science.1173890
-
Pseudogene accumulation in the evolutionary histories of Salmonella enterica serovars Paratyphi A and Typhi.
BMC genomics 2009;10;36
PUBMED: 19159446; PMC: 2658671; DOI: 10.1186/1471-2164-10-36
-
Comparative genome and phenotypic analysis of Clostridium difficile 027 strains provides insight into the evolution of a hypervirulent bacterium.
Genome biology 2009;10;9;R102
PUBMED: 19781061; PMC: 2768977; DOI: 10.1186/gb-2009-10-9-r102
-
Complete genome sequence and comparative genome analysis of enteropathogenic Escherichia coli O127:H6 strain E2348/69.
Journal of bacteriology 2009;191;1;347-54
PUBMED: 18952797; PMC: 2612414; DOI: 10.1128/JB.01238-08
-
Typhoid Fever
Vaccines for Biodefense and Emerging and Neglected Diseases 2009;Chapter 57;1147–1161
DOI: 10.1016/B978-0-12-369408-9.00057-3; URL: http://www.sciencedirect.com/scien...ce/article/pii/B9780123694089000573
-
Comparative genome analysis of Salmonella Enteritidis PT4 and Salmonella Gallinarum 287/91 provides insights into evolutionary and host adaptation pathways.
Genome research 2008;18;10;1624-37
PUBMED: 18583645; PMC: 2556274; DOI: 10.1101/gr.077404.108
-
High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi.
Nature genetics 2008;40;8;987-93
PUBMED: 18660809; PMC: 2652037; DOI: 10.1038/ng.195
-
The neglected role of antibody in protection against bacteremia caused by nontyphoidal strains of Salmonella in African children.
The Journal of clinical investigation 2008;118;4;1553-62
PUBMED: 18357343; PMC: 2268878; DOI: 10.1172/JCI33998
-
Molecular characterization of the Salmonella enterica serovar Typhi Vi-typing bacteriophage E1.
Journal of bacteriology 2008;190;7;2580-7
PUBMED: 18192390; PMC: 2293211; DOI: 10.1128/JB.01654-07
-
A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi.
Molecular microbiology 2007;66;5;1207-18
PUBMED: 17976161; PMC: 2652032; DOI: 10.1111/j.1365-2958.2007.05995.x
-
Salmonella enterica serovar typhimurium exploits inflammation to compete with the intestinal microbiota.
PLoS biology 2007;5;10;2177-89
PUBMED: 17760501; PMC: 1951780; DOI: 10.1371/journal.pbio.0050244
-
The genome of Salmonella enterica serovar Typhi.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2007;45 Suppl 1;S29-33
PUBMED: 17582565; DOI: 10.1086/518143
-
Multidrug-resistant Salmonella enterica serovar paratyphi A harbors IncHI1 plasmids similar to those found in serovar typhi.
Journal of bacteriology 2007;189;11;4257-64
PUBMED: 17384186; PMC: 1913411; DOI: 10.1128/JB.00232-07
-
Requirement of bic/microRNA-155 for normal immune function.
Science (New York, N.Y.) 2007;316;5824;608-11
PUBMED: 17463290; PMC: 2610435; DOI: 10.1126/science.1139253
-
The complete genome sequence and comparative genome analysis of the high pathogenicity Yersinia enterocolitica strain 8081.
PLoS genetics 2006;2;12;e206
PUBMED: 17173484; PMC: 1698947; DOI: 10.1371/journal.pgen.0020206
-
Evolutionary history of Salmonella typhi.
Science (New York, N.Y.) 2006;314;5803;1301-4
PUBMED: 17124322; PMC: 2652035; DOI: 10.1126/science.1134933
-
The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome.
Nature genetics 2006;38;7;779-86
PUBMED: 16804543; DOI: 10.1038/ng1830
-
Complete genome sequence of a multiple drug resistant Salmonella enterica serovar Typhi CT18.
Nature 2001;413;6858;848-52
PUBMED: 11677608; DOI: 10.1038/35101607
-
Genome sequence of Yersinia pestis, the causative agent of plague.
Nature 2001;413;6855;523-7
PUBMED: 11586360; DOI: 10.1038/35097083