Danesh Group | Danesh Group

Danesh Group | Danesh Group

Danesh Group


Danesh, John
Professor John Danesh
Group Leader

As an Faculty member Danesh works to further understand cardiometabolic traits through combining cardiovascular epidemiology with genomic research techniques. His research focus is on providing novel insights into the causes and predictors of coronary heart disease.

Programmes, Associate Research Programmes and Facilities


  • PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations.

    Kamat MA, Blackshaw JA, Young R, Surendran P, Burgess S et al.

    Bioinformatics (Oxford, England) 2019

  • Genetic Risk Score for Coronary Disease Identifies Predispositions to Cardiovascular and Noncardiovascular Diseases.

    Ntalla I, Kanoni S, Zeng L, Giannakopoulou O, Danesh J et al.

    Journal of the American College of Cardiology 2019;73;23;2932-2942

  • Genetically modulated educational attainment and coronary disease risk.

    Zeng L, Ntalla I, Kessler T, Kastrati A, Erdmann J et al.

    European heart journal 2019

  • Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.

    Peloso GM, Nomura A, Khera AV, Chaffin M, Won HH et al.

    Circulation. Genomic and precision medicine 2019;12;5;e002376

  • Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study.

    Zheng JS, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I et al.

    The Journal of clinical endocrinology and metabolism 2019;104;4;1293-1303

  • Assessing the causal association of glycine with risk of cardio-metabolic diseases.

    Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P et al.

    Nature communications 2019;10;1;1060

  • New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries.

    Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD et al.

    Nature genetics 2019;51;3;481-493

  • Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution.

    Justice AE, Karaderi T, Highland HM, Young KL, Graff M et al.

    Nature genetics 2019;51;3;452-469

  • Interleukin-6 Receptor Signaling and Abdominal Aortic Aneurysm Growth Rates.

    Paige E, Clément M, Lareyre F, Sweeting M, Raffort J et al.

    Circulation. Genomic and precision medicine 2019;12;2;e002413

  • Genetic effects on promoter usage are highly context-specific and contribute to complex traits.

    Alasoo K, Rodrigues J, Danesh J, Freitag DF, Paul DS and Gaffney DJ

    eLife 2019;8

  • Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci.

    Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G et al.

    Molecular psychiatry 2019

  • DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.

    Emdin CA, Khera AV, Aragam K, Haas M, Chaffin M et al.

    Diabetes 2019;68;1;226-234