Behjati Group | Cancer genomics & single cell transcriptomics

Behjati Group | Cancer genomics & single cell transcriptomics

Behjati Group

Our Research and Approach

Our research sits at the interface of cancer genomics and single cell transcriptomics. Our aim is to unravel the identity and origin of cancer cells. We have a particular focus on childhood cancer.


Behjati, Sam
Sam Behjati
Group Leader

I am a Paediatrician Scientist and Group Leader working across Cellular Genetics and Cancer. I am broadly interested in the developmental origins of cancer, especially of childhood cancer. To that end we combine cutting single cell transcriptomics with cancer genomics.

Show Alumni


Sarah Farndon (Clinical Masters' student)

Key Projects, Collaborations, Tools & Data

Programmes, Associate Research Programmes and Facilities

Partners and Funders

Internal Partners


  • Spatiotemporal immune zonation of the human kidney.

    Stewart BJ, Ferdinand JR, Young MD, Mitchell TJ, Loudon KW et al.

    Science (New York, N.Y.) 2019;365;6460;1461-1466

  • Decoding human fetal liver haematopoiesis.

    Popescu DM, Botting RA, Stephenson E, Green K, Webb S et al.

    Nature 2019;574;7778;365-371

  • Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

    Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A et al.

    Science (New York, N.Y.) 2018;361;6405

  • Single-cell transcriptomes from human kidneys reveal the cellular identity of renal tumors.

    Young MD, Mitchell TJ, Vieira Braga FA, Tran MGB, Stewart BJ et al.

    Science (New York, N.Y.) 2018;361;6402;594-599

  • Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

    Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ et al.

    Nature communications 2018;9;1;2378

  • Recurrent rearrangements of FOS and FOSB define osteoblastoma.

    Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC et al.

    Nature communications 2018;9;1;2150

  • Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

    Collord G, Martincorena I, Young MD, Foroni L, Bolli N et al.

    British journal of haematology 2019;184;4;676-679

  • Mapping human development at single-cell resolution.

    Behjati S, Lindsay S, Teichmann SA and Haniffa M

    Development (Cambridge, England) 2018;145;3

  • The driver landscape of sporadic chordoma.

    Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB et al.

    Nature communications 2017;8;1;890

  • Genetics: Taking single-cell transcriptomics to the bedside.

    Behjati S and Haniffa M

    Nature reviews. Clinical oncology 2017;14;10;590-592

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Behjati S, Tarpey PS, Haase K, Ye H, Young MD et al.

    Nature communications 2017;8;15936

  • Molecular diagnoses of century-old childhood tumours.

    Virasami A, Farndon SJ, McDermott U, Sebire N and Behjati S

    The Lancet. Oncology 2017;18;5;e237

  • Retracing embryological fate.

    Behjati S

    Science (New York, N.Y.) 2016;354;6316;1109

  • Mutational signatures of ionizing radiation in second malignancies.

    Behjati S, Gundem G, Wedge DC, Roberts ND, Tarpey PS et al.

    Nature communications 2016;7;12605

  • Genome sequencing of normal cells reveals developmental lineages and mutational processes.

    Behjati S, Huch M, van Boxtel R, Karthaus W, Wedge DC et al.

    Nature 2014;513;7518;422-425

  • Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

    Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P et al.

    Nature genetics 2014;46;4;376-379

  • Distinct H3F3A and H3F3B driver mutations define chondroblastoma and giant cell tumor of bone.

    Behjati S, Tarpey PS, Presneau N, Scheipl S, Pillay N et al.

    Nature genetics 2013;45;12;1479-82

  • Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma.

    Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC et al.

    Nature genetics 2013;45;8;923-6