Rutledge, Gavin G.
Gavin is a final-year PhD student co-supervised by Dr. Matt Berriman and Prof. Dominic Kwiatkowski. Gavin's PhD project involves analysing the DNA sequences of human malaria parasites to elucidate their evolutionary history and to better understand the genetic basis of antimalarial drug resistance. Gavin is due to complete his PhD by October 2018.
Brief Research Summary
As intensive control efforts are successfully reducing malaria prevalence in many countries, the focus is now shifting towards more targeted interventions that rely on effective surveillance mechanisms. Using the information encoded in the genome sequences of malaria parasites to monitor changes in transmission dynamics and drug resistance occurrence presents a cost-effective way of surveillance. Gavin's PhD project consists of multiple strands of research, including assembling genome sequences of neglected malaria parasite species to enable their study and surveillance, connecting genetic data to drug resistance phenotype data to better understand the genetic basis of antimalarial drug resistance, as well as developing the mathematical models needed to convert these genetic findings from multiple genome sequences into actionable public health measures.
Gavin completed his BSc (Hons.) in Biology and English with First class honours at the University of Keele, UK, in 2012 and was awarded the Society of Biology Top Student award. He subsequently completed an MSc in Quantitative Biology at Imperial College London, UK, in 2013, where he was awarded the William Harvey Prize and where he analysed patterns of genetic differentiation in wild mosquito populations under the supervision of Prof. Austin Burt. He concurrently completed an MA in English Literature at King's College London, UK, where he wrote on the representation of malaria in literature. Following a year of teaching natural sciences at a secondary school in Luxembourg and concluding a research internship at the Beijing Genomics Institute (BGI) in Shenzhen, China, Gavin joined the Sanger PhD Programme in 2014.
Since joining the Sanger Institute, Gavin has completed rotation projects with Dr. Julian Rayner and Dr. Oliver Billker, analysing vector integration efficiencies of PlasmoGEM vectors, with Dr. Matt Berriman, performing network analyses of dual RNA-seq data in rodent malaria, and with Prof. Dominic Kwiatkowski, developing selective Whole Genome Amplification (sWGA) protocols for human malaria samples. In 2015, Gavin began his PhD project co-supervised by Dr. Matt Berriman and Prof. Dominic Kwiatkowski, as well as advised by Dr. Thomas Otto and Dr. Roberto Amato, analysing the genome sequences of neglected human malaria parasites and studying the genetic basis of antimalarial drug resistance.
Gavin has recently been selected to represent Luxembourg at the 2018 Lindau Nobel Laureate Meeting, a prestigious meeting bringing together early career researchers from across the globe to engage with Nobel laureates.
Genomic Characterization of Recrudescent Plasmodium malariae after Treatment with Artemether/Lumefantrine.
Emerging infectious diseases 2017;23;8;1300-1307
Plasmodium malariae and P. ovale genomes provide insights into malaria parasite evolution.
Finding the needle in the haystack.
Nature reviews. Microbiology 2017;15;3;136
Last parasite standing.
Nature reviews. Microbiology 2016;15;1;4
Whole genome sequencing of Plasmodium falciparum from dried blood spots using selective whole genome amplification.
Malaria journal 2016;15;1;597
Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes.
An improved Plasmodium cynomolgi genome assembly reveals an unexpected methyltransferase gene expansion.
Wellcome open research 2017;2;42