Flatworm Functional Genomics Initiative (FUGI)

Flatworm Functional Genomics Initiative (FUGI)

Flatworm Functional Genomics Initiative (FUGI)

A consortium funded by a Wellcome Trust Strategic Award to develop game-changing research tools for the study and manipulation of parasitic flatworm species responsible for the devastating diseases echinococcosis (hydatid disease) and schistosomiasis (bilharzia).

About the Partnership


FUGI proposes three primary aims:

  • ‘Poly-omics’ characterisation of stem cell systems in S. mansoni (neoblast-like somatic cells, S1 vitellocytes and oogonia) and E. multilocularis (germinative cells).
  • Development of S. mansoni and E. multilocularis reverse genetic toolkits.
  • Establishment of E. multilocularis and S. mansoni immortal cell lines.

Dr. Matt Berriman, Wellcome Sanger Institute

Prof. Klaus Brehm, University of Würzburg, Germany

Prof. Paul Brindley, The George Washington University, USA

Dr. James Collins, UT Southwestern Medical Center, USA

Prof. Christoph Grevelding, University of Giessen, Germany

Prof. Christoph Grunau, University Perpignan, France

Prof. Karl Hoffmann, University of Aberystwyth, Wales

Prof. Ludovic Vallier, Cambridge Stem Cell Institute

Consortium Administrator: Jessica Longworth, University of Aberystwyth, Wales

Sanger Team Partners


  • A gene expression atlas of adult Schistosoma mansoni and their gonads.

    Lu Z, Sessler F, Holroyd N, Hahnel S, Quack T et al.

    Scientific data 2017;4;170118

  • Double impact: natural molluscicide for schistosomiasis vector control also impedes development of Schistosoma mansoni cercariae into adult parasites.

    Augusto RC, Tetreau G, Chan P, Walet-Balieu ML, Mello-Silva CC et al.

    PLoS neglected tropical diseases 2017;11;7;e0005789

  • (Epi)genetic Inheritance in Schistosoma mansoni: A Systems Approach.

    Cosseau C, Wolkenhauer O, Padalino G, Geyer KK, Hoffmann KF and Grunau C

    Trends in parasitology 2017;33;4;285-294

  • Tissue Degeneration following Loss of Schistosoma mansoni cbp1 Is Associated with Increased Stem Cell Proliferation and Parasite Death In Vivo.

    Collins JN and Collins JJ

    PLoS pathogens 2016;12;11;e1005963

  • RecQL4 regulates autophagy and apoptosis in U2OS cells.

    Duan Y and Fang H

    Biochemistry and cell biology = Biochimie et biologie cellulaire 2016;94;6;551-559

  • HIV-1 Integrates Widely throughout the Genome of the Human Blood Fluke Schistosoma mansoni.

    Suttiprapa S, Rinaldi G, Tsai IJ, Mann VH, Dubrovsky L et al.

    PLoS pathogens 2016;12;10;e1005931

  • Schistosome sex matters: a deep view into gonad-specific and pairing-dependent transcriptomes reveals a complex gender interplay.

    Lu Z, Sessler F, Holroyd N, Hahnel S, Quack T et al.

    Scientific reports 2016;6;31150

  • Schistosomiasis as a disease of stem cells.

    Wendt GR and Collins JJ

    Current opinion in genetics & development 2016;40;95-102

  • Derivatives of biarylalkyl carboxylic acid induce pleiotropic phenotypes in adult Schistosoma mansoni in vitro.

    Blohm AS, Mäder P, Quack T, Lu Z, Hahnel S et al.

    Parasitology research 2016;115;10;3831-42

  • Medicine. Halting harmful helminths.

    Hoffmann KF, Brindley PJ and Berriman M

    Science (New York, N.Y.) 2014;346;6206;168-9

  • Identification of new markers for the Schistosoma mansoni vitelline lineage.

    Wang J and Collins JJ

    International journal for parasitology 2016;46;7;405-10