Dr Matthew Forbes
Senior Data Scientist
Working in the Data analysis teams for the Covid-19 and Malaria genomic surveillance teams. Formerly Dr Matthew Sinnott.
I completed my undergraduate degree in Biochemistry with a Year in Research at Imperial College London in 2016, completing my undergraduate project with Prof. Jake Baum on purification and binding analyses of the Essential Light Chain in Plasmodium falciparum.
During this time I also had the opportunity to work for a year in the Plant Biology and Crop Sciences division at Rothamstead Research. The goal of this project was to investigate changes in cell wall composition in the starchy endosperm of wheat lines which had suppressed/increased expression of certain glycosyl transferases.
I then went on to a 4 year PhD at the Institute of Structural and Molecular Biology (ISMB), a partnership between Birkbeck College and University College London. My main project was with Prof. Maya Topf and Prof. Konstantinos Thalassinos in the development of computational methods to analyse protein structure using data from a technique called Chemical Crosslinking Mass Spectrometry. In this project we published a paper in the journal Structure where we devised a methodology to use monolinks, a previously unused by-product produced in the cross-linking procedure, to score model protein structures.
My Role at Sanger
I am currently working in the data analysis in the Covid-19 team and in the malaria surveillance operations (part of MalariaGen).
In the Covid-19 data analysis team I support the development and maintanance of the Sanger Institute’s public dashboard (covid19.sanger.ac.uk). In the Malaria team I work on various projects to make insights from complex genomic datasets to assist in the surveillance of Malaria acros the world.