Vitalii Kleshchevnikov | PhD Student

Kleshchevnikov, Vitalii

I am investigating how gene expression states of cells are linked to cell contact neighbourhoods in tissues.

Cataloging and comparing the patterns of cell-cell contacts, their transcriptional dependencies and consequences is essential for understanding the molecular rules that govern both the structure of tissues and the context-dependent cell functions.
I use single-cell transcriptomics of isolated cells, highly-multiplexed large-scale in-situ quantification of gene expression and systems biology tools to characterise transcriptional states of neighbouring cells. To interpret scRNA-seq & spatial gene expression and ask quantitative questions I develop probabilistic models of the underlying generative process.

Publications

  • Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

    Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V et al.

    Nature biotechnology 2018

  • Predicting the mutations generated by repair of Cas9-induced double-strand breaks.

    Allen F, Crepaldi L, Alsinet C, Strong AJ, Kleshchevnikov V et al.

    Nature biotechnology 2018

Kleshchevnikov, Vitalii
Vitalii's Timeline
2018

PhD @ Wellcome Sanger Institute & University of Cambridge

Visiting Scientist @ Parts group, Wellcome Sanger Institute

2017

Intern @ Petsalaki group, European Bioinformatics Institute

2016

MSc @ Taras Shevchenko National University of Kyiv

2015

Intern @ Colin Stewart lab, Institute of Medical Biology, A*STAR

2014

BUSS Summer School @ University of Zurich & ETH Zurich

2012

BSc @ Taras Shevchenko National University of Kyiv