Vertebrate Genomes Project

Vertebrate Genomes Project

Vertebrate Genomes Project

The Vertebrate Genomes Project (VGP) at the Sanger Institute aims to provide reference quality assemblies for hundreds of fish, rodents and caecilians to contribute to the Tree of Life Sequencing effort. The current pilot focusses on cyprinids, cichliforms, notothenioid and anabantoid fishes, as well as select rodents and caecilians.

Groups

Population and evolutionary genomics, novel computational genomics methods, and related mathematical and statistical models.

The Vertebrate Resequencing (VR) team are responsible for handling the informatics and large scale sequencing projects for the Durbin and Adams groups.

The Genome Reference Informatics Team analyses genome assemblies to reveal and correct quality issues and to identify and add variation. It forms the Sanger division of the Genome Reference Consortium and the Vertebrate Genomes Project.

Many high profile projects such as the Cancer Genome and 1000 Genomes projects need quality assemblies for downstream analysis using 2nd and 3rd generation sequencing data. Efficient bioinformatics tools in processing and analysis of large quantities of genomic data play crucial roles in producing high quality assemblies as well as variation detection. The High Performance Assembly Group (HPAG), headed by Zemin Ning, develops algorithms and software tools for genome analysis. Currently the team is also involved in data processing and quality evaluation of Oxford Nanopore sequencing technology.

The DNA Pipelines Research and Development group is the entry point for new technologies to the Institute, especially sequencing instruments. The team develops new methods and procedures to maximise the efficiency, quality and throughput of all incoming machinery for the benefit all Institute researchers.