Jones Group | Pre-cancer

Jones Group | Pre-cancer

Jones Group

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Our Research and Approach

Our group studies how normal cell behaviour is altered by mutation in the early stages of cancer evolution. We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

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People

Phil H Jones
Group Leader
Phil studies the earliest steps in cancer development, how specific alterations in the DNA of normal stem cells changes their behaviour to promote tumour formation.
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Alumni

Research Programmes and Faciltites

Partners and Funders

External Partners and Funders

Publications

  • Somatic mutant clones colonize the human esophagus with age.

    Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F et al.

    Science (New York, N.Y.) 2018

  • Epidermal Tissue Adapts to Restrain Progenitors Carrying Clonal p53 Mutations.

    Murai K, Skrupskelyte G, Piedrafita G, Hall M, Kostiou V et al.

    Cell stem cell 2018;23;5;687-699.e8

  • A single dividing cell population with imbalanced fate drives oesophageal tumour growth.

    Frede J, Greulich P, Nagy T, Simons BD and Jones PH

    Nature cell biology 2016;18;9;967-78

  • Human keratinocytes have two interconvertible modes of proliferation.

    Roshan A, Murai K, Fowler J, Simons BD, Nikolaidou-Neokosmidou V and Jones PH

    Nature cell biology 2016;18;2;145-56

  • Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

    Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al.

    Science (New York, N.Y.) 2015;348;6237;880-6

  • Switching roles: the functional plasticity of adult tissue stem cells.

    Wabik A and Jones PH

    The EMBO journal 2015;34;9;1164-79

  • Cell competition: winning out by losing notch.

    Alcolea MP and Jones PH

    Cell cycle (Georgetown, Tex.) 2015;14;1;9-17

  • Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change.

    Alcolea MP, Greulich P, Wabik A, Frede J, Simons BD and Jones PH

    Nature cell biology 2014;16;6;615-22

  • Tracking cells in their native habitat: lineage tracing in epithelial neoplasia.

    Alcolea MP and Jones PH

    Nature reviews. Cancer 2013;13;3;161-71

  • A single progenitor population switches behavior to maintain and repair esophageal epithelium.

    Doupé DP, Alcolea MP, Roshan A, Zhang G, Klein AM et al.

    Science (New York, N.Y.) 2012;337;6098;1091-3