Archive Page: Bird Group | Epigenetic mechanisms in health and disease

Archive Page: Bird Group | Epigenetic mechanisms in health and disease

Bird Group

This page is being maintained as historical record of the work of Adrian Bird's Associate Faculty Group at the Wellcome Sanger Institute and is no longer being updated.

Our Research and Approach

Cpg_island_evolution1.pngWikimedia Commons

Adrian's research group is interested in the way chemical marking of chromosomes influences genome activity in normal cells and in disease. In particular, the team focuses on:

  • The function of long non-coding RNAs originating at CpG island promoters
  • The effects of a methylated DNA binding protein on gene expression

To read more about these projects, please click on 'Read more'.

Read More

People

Bird, Adrian
Adrian Bird
Group Leader

Adrian's research focus explores the way chemical marking of chromosomes influences genome activity in normal cells and in disease. As a member of Associate Faculty he pursued research projects in collaboration with Sanger scientists, taking advantage of the Institute's strength in large-scale genetics and genomics.

Research Programmes and Faciltites

Partners and Funders

Internal Partners
External Partners and Funders

Publications

  • Rett syndrome: a complex disorder with simple roots.

    Lyst MJ and Bird A

    Nature reviews. Genetics 2015;16;5;261-75

  • Synthetic CpG islands reveal DNA sequence determinants of chromatin structure.

    Wachter E, Quante T, Merusi C, Arczewska A, Stewart F et al.

    eLife 2014;3;e03397

  • Rett syndrome mutations abolish the interaction of MeCP2 with the NCoR/SMRT co-repressor.

    Lyst MJ, Ekiert R, Ebert DH, Merusi C, Nowak J et al.

    Nature neuroscience 2013;16;7;898-902

  • CpG islands and the regulation of transcription.

    Deaton AM and Bird A

    Genes & development 2011;25;10;1010-22