Staff PhD and MPhil theses can be downloaded here.

Staff PhD and MPhil theses can be downloaded here.

For each thesis there are two links (if available):

  • a PDF of the thesis;
  • a compressed archives of the PDF files and any supporting files.

PhD theses

Year Author Title Download
2006 Akan, Pelin Identification and Characterisation of Regulatory Elements on Human Chromosome 20q12-13.2 Thesis Files
2013 Al Turki, Saeed Integrated approaches to elucidate the genetic architecture of congenital heart defects Thesis Files
2016 Alasoo, Kaur Regulation of gene expression in macrophage immune response Thesis Files
2014 Alexandrov, Ludmil Signatures of Mutational Processes in Human Cancer Thesis Files
2019 Ansbro, Megan Rose An investigation of the mechanisms of piperaquine resistance in Plasmodium falciparum malaria Thesis Files
2019 Antunes, Liliana Freitas Genome-wide search for regulators of the first cell lineage decision in the mouse: a CRISPR/Cas9 endeavour Thesis Files
2016 Archer, Eva Jacqueline Simian Immunodeficiency Virus Infection of CD4+ T Cell Subsets and Its Impact on B Cell Responses in Early Infection Thesis Files
2019 Arciero, Elena Human population history and genetic adaptation in the Himalayan region Not available
2013 Assefa, Sammy De novo assembly of the var multi-gene family in clinical samples of Plasmodium falciparum Thesis Files
2006 Bacha, Jamil Studies of the effects of promoter sequence variation on gene expression in human chromosome 22 Thesis Files
2020 Bai, Benjamin Yu Hang Genomic profiling of response to in vivo immune perturbations Thesis Files
2013 Barquist, Lars High-throughput Experimental and Computational Studies of Bacterial Evolution Thesis Files
2004 Barrett, Ian Gene identification and characterisation on the human X chromosome Thesis Files
2014 Bashford-Rogers, Rachael Analysing the B-cell repertoire: Investigating B-cell population dynamics in health and disease. Thesis Files
2014 Batista Gomes, Ana Rita High-throughput reverse genetic screening in Plasmodium berghei using barcode sequencing Thesis Files
2017 Bergström, Anders Genomic insights into the human population history of Australia and New Guinea Thesis Files
2010 Bird, Christine The evolution of functional non-coding DNA in humans Not available
2000 Birney, Ewan Sequence alignment in bioinformatics. Not available
2004 Blow, Matthew J Survey of RNA editing in the human brain Thesis Files
2009 Brosch, Markus Development of computational methods for analysing proteomic data for genome annotation Thesis Files
2014 Bryant, Josephine M Evolutionary Genomics of Pathogenic Mycobacteria Thesis Files
2010 Buljan, Marija Mechanisms of change in protein architecture Thesis Files
2007 Burford, Deborah Rearrangement breakpoints and viral integration sites in the human genome Thesis Files
2012 Calafato, Stella Uncovering the role of common and rare variants in migraine Thesis Files
2019 Calvert, Fiona Elizabeth The Transcriptional Profile of Microglia: From Brain to Dish Thesis Files
2020 Camarillo Guerrero, Luis Fernando Integrative Analysis of the Human Gut Phageome Using a Metagenomics Approach Thesis Files
2014 Carss, Keren Identifying and modelling genes that are associated with rare developmental disorders Thesis Files
2007 Chen, Yen-Yu (Leslie) Genetics of the anticoagulant drug warfarin Thesis Files
2014 Chewapreecha, Claire Evolution of Streptococcus pneumoniae during carriage Thesis Files
2017 Chia, Crystal Ying The role of transcription factor GATA6 in the development of the human pancreas Thesis Files
2000 Coffey, Alison J Physical mapping on the human X chromosome and its application to the positional cloning of the XLP gene Not available
2005 Coin, Lachlan Protein Domains: New methods for detection and evolutionary analysis Thesis Files
2019 Collord, Grace The pre-clinical evolution of haematological malignancies Thesis Files
2020 Coorens, Tim Lineage tracing of normal human development and childhood cancers Thesis Files
1994 Coulson, Alan The physical map of the genome of Caenorhabditis elegans Not available
2011 Croucher, Nicholas Functional and evolutionary analyses of pneumococcal genome variation Thesis Files
2005 Cuthbert, Peter Role of Synapse-Associated Protein 102 in Postsynaptic Signalling, Synaptic Plasticity and Learning Thesis Files
2016 David, Sophia The diversity of disease-causing and environmental Legionella pneumophila Thesis Files
2009 Davis, Matthew Generation of a murine ES cell system deficient in microRNA processing for the identification of microRNA targets Thesis Files
2004 Davison, Eleanor Chromosomal imbalances in colorectal cancer Thesis Files
2017 de Lange, Katrina Melanie Understanding inflammatory bowel disease using high-throughput sequencing Thesis Files
2017 Dentro, Stefan Christiaan The Intra-Tumour Heterogeneity Landscape of Human Cancers Thesis Files
2005 Dhami, Pawandeep The SCL Gene and Transcriptional Control of Haematopoiesis Thesis Files
2008 Dillon, Shane Development of Chromatin Immuniprecipitation Microarray Technology for the Identification of Regulatory Elements in the Human Genome Thesis Files
2009 Dimas, Antigone The role of regulatory variation in sculpting gene expression across human populations and cell types Thesis Files
2014 Ding, Zhihao The Genetics of Cellular Phenotypes Thesis Files
2008 Dogruel, Mutlu Motif based computational identification of protein subcellular localisation Thesis Files
2020 Dorman, Matthew James Exploring the genomic and phenotypic diversity of the Vibrio cholerae species Thesis Files
2003 Down, Thomas Computational localization of promoters and transcription start sites in mammalian genomes Thesis Files
1987 Durbin, Richard Studies on the development and organisation of the nervous system of Caenorhabditis elegans Thesis Files
2005 Eades, Tamsin L An Analysis of Transcript Variation in Human Xp11.23 Thesis Files
2013 Everitt, Aaron Investigating the Role of Interferon-Inducible Transmembrane 3 (IFITM3) in Infection. Thesis Files
2008 Fawcett, Katherine Genetic Studies of Syndromes of Severe Insulin Resistance and Type 2 Diabetes: a candidate gene approach Thesis Files
2018 Garrison, Erik Peter Graphical pangenomics Thesis Files
2016 Goncalves Serra, Eva Understanding human disease using high-throughput sequencing Thesis Files
2020 Goode, Elizabeth Claire Primary sclerosing cholangitis: from genetic risk to disease biology Thesis Files
2002 Goward, Melanie Structural, functional and comparative studies of human chromosome 22q13.31 Thesis Files
2003 Gregory, Simon Chromosome 1 map, sequence and variation Thesis Files
2014 Grove, Carolyn A Study of Molecular Synergy and Clonal Evolution in Haematopoietic Malignancies Thesis Files
2004 Guo, Ge Recessive genetic screen for mismatch repair components in BLM-deficient ES cells Thesis Files
2004 Gwilliam, Rhian Finding genes involved in corneal endothelial dystrophies linked to human chromosome 20 Not available
2005 Hajarnavis, Ashwin Computational Detection and Analysis of Polyadenylation Signals Thesis Files
2007 Hall, Lindsay Phenotypic and Functional Characterisation of Innate and Adaptive Immune Responses after Mucosal Vaccination Thesis Files
2003 Hasan, Samiul Prediction and analysis of nucleosome positioning in genomic sequences Thesis Files
2011 He, Miao Genomic variation and evolution of Clostridium difficile Thesis Files
2016 Herzog, Mareike DNA polymerase mutations as drivers of genome instability and cancer Thesis Files
2015 Hill, Jennifer A functional genomic-based study of the streptomycin mouse model of human Salmonella Typhimurium gastroenteritis Thesis Files
2012 Hilton, Jennifer Progressive hearing loss in mouse mutants Not available
1998 Holmes, Ian Studies in probabilistic sequence alignment and evolution Thesis Files
2009 Holt, Kathryn Genomic variation and evolution of Salmonella enterica serovars Typhi and Paratyphi A Thesis Files
2020 Horesh, Gal Redefining gene distributions in K. pneumoniae and E. coli using large public datasets Thesis Files
2016 Hostetler, Jessica Blythe Identification of novel Plasmodium Vivax blood-stage vaccine targets Thesis Files
2003 Howe, Kevin Gene prediction using a configurable system for the integration of data by Dynamic programming Thesis Files
2002 Howell, Gareth Physical, transcriptional and comparative mapping on the human X chromosome Thesis Files
2012 Hu, Min Positive natural selection in the human genome Thesis Files
2015 Huang, Jie Whole-genome Sequencing-based Association Studies of Cardiovascular Biomarkers Thesis Files
2011 Huang, Ni The functional impact of copy number variation in the human genome Thesis Files
2008 Huang, Yen-Hua Computational detection of non-coding RNAs in genomes Thesis Files
2015 Iantorno, Stefano Genome plasticity and genetic exchange in Leishmania tropica Thesis Files
2008 Ikediobi, Ogechi Characterization of Cancer Gene Mutations in Human Cancer Cell lines for Correlation with Drug Activity Thesis Files
2008 Jim, Hau Ling Identification of target genes of an erythroid transcription factor complex containing SCL(TAL1) Thesis Files
2010 John, Victoria A role for microRNA-155 in the control of infection Thesis Files
1999 Jones, Steve Computational analysis of the Caenorhabditis elegans genome sequence Not available
2017 Jones, Wendy Dawn Genetic and phenotypic investigations into developmental disorders Thesis Files
2012 Jostins, Luke Using Next-Generation Genomic Datasets In Disease Association Thesis Files
2006 Kalaitzopoulos, Dimitrios Molecular characterization and computational analysis of constitutional chromosome rearrangements Not available
2020 Kaplanis, Joanna Germline mutation in rare disease Thesis Files
2005 Kay, Emily Identification of Genetic Differences Between Strains of Campylobacter jejuni Thesis Files
2020 Kelemen, Marton Modelling human complex traits with regression and neural-network based methods Thesis Files
2006 Kenyon, Emma Investigations into the Rab family of genes and their roles in signalling during vertebrate early development Thesis Files
2015 King, Daniel Alexander Uniparental disomy and mosaic structural variation in developmental disorders Thesis Files
2016 Kolodziejczyk, Aleksandra Anna Single cell mRNA-sequencing of mESCs reveals cell-to-cell variation in pluripotency and cell cycle genes Thesis Files
2011 Kong, Jun Transposon-mediated Insertional Mutagenesis in Gene Discovery and Cancer Thesis Files
2018 Kosicki, Michal Konrad Cas9-induced on-target genomic damage Thesis Files
2007 Lackner, Daniel Genome-Wide Translational Control In Fission Yeast Thesis Files
2013 Lam Hung, Laure The ribosomal RNA processing gene nucleolar protein 9 (nol9) is essential for normal exocrine pancreas development in zebrafish Thesis Files
2003 Langford, Cordelia Karyotype Evolution: Evolutionary Chromosome Rearrangements in Material Homologous to Human Chromosome 22q Studied in the Dog and Gibbon Thesis Files
2010 Langridge, Gemma C Metabolic capability in host-restricted serovars of Salmonella enterica Thesis Files
2018 Lee-Six, Henry Somatic evolution in human blood and colon Thesis Files
2008 Lee, Song Choon Characterisation of bcl11 functions in development using genetically modified mice Thesis Files
2019 Lees, Emily Ann Modelling the interactions of Salmonellae with the human host using stem cell-derived intestinal organoids and macrophages Thesis Files
2017 Lees, John Andrew Host and pathogen genetics associated with pneumococcal meningitis Thesis Files
2010 Li, Meng A recessive genetic screen to discover components in miRNA pathways using piggyBac-mediated insertional mutagenesis in Blm-deficient mouse embryonic stem cells Thesis Files
2017 Li, Meng Genetic Dissection of the Exit from Pluripotency in Mouse Embryonic Stem Cells by CRISPR-based Screening Thesis Files
2010 Li, Peng Reprogramming of T cells to natural killer-like cells upon BCL11B deletion Thesis Files
2009 Liang, Qi A genetic screen for tumour suppressor genes using the sleeping beauty and piggybac transposon systems Not available
2014 Liu, Jimmy The genetic architecture of immune-mediated complex diseases Thesis Files
2008 Liu, Mengning Evolutionary Landscape of CpG Island Methylation in X Chromosome Inactivation Thesis Files
2009 Mahoney, Claire Identification and Functional Characterisation of a Genetic Subset of Non-Small Cell Lung Cancer Thesis Files
2015 Malinsky, Milan Genomic diversity and speciation in East African cichlid fish Thesis Files
2011 Manakou, Siarhei The role of microRNAs in neurons - (Also known as Sergei A Manakov) Thesis Files
2008 Mattison, Jenny Analysis of genome-wide, cancer-associated mutation datasets in mouse and human Thesis Files
1997 McDougall, Rachel C Schizosaccharomyces pombe: from sequence to function Not available
2002 Meyer, Imtraud Mathematical methods for comparative ab initio gene prediction Thesis Files
2011 Migdalska, Anna Modelling Human Genetic Disorders in Mice Thesis Files
2007 Minichiello, Mark Analysis of genetic variation data using Ancestral Recombination Graphs Thesis Files
2007 Mungall, Andy Evolution and gene regulation of the genomic imprinting mechanism Thesis Files
2014 Mutreja, Ankur The Origins and Evolution of Vibrio cholerae O1 El Tor Thesis Files
2008 Nelson, Andrew Analysis of the transcriptomes of wild-type and mutant C. elegans Thesis Files
2010 Nica, Alexandra C Regulatory variation and its role in disease Thesis Files
2012 Nik-Zainal, Serena Exploring mutational signatures in twenty-one breast cancers Thesis Files
2018 Noorani, Imran Genetic dissection of EGFRvIII brain and spinal mouse gliomas through whole-exome sequencing and in vivo piggyback mutagenesis forward genetic screening Thesis Files
2012 Ooi, Jolene The Role of Retinoic Acid Receptors in the Replacement of Oct4 during the Generation of Induced Pluripotent Stem Cells Thesis Files
2019 Parada González, Guillermo Eduardo Computational analyses of non-canonical architectural and structural features associated with alternative splicing Thesis Files
2011 Parts, Leopold Genetic mapping of cellular traits Thesis Files
2012 Paul, Dirk Maps of open chromatin - from genetic signals to function Thesis Files
2009 Perkins, Timothy Characterisation of the Transcriptome and Proteome of Salmonella enterica subspecies enterica serovar Typhi Thesis Files
2014 Perrin, Abigail Identification and characterisation of host-pathogen protein-protein interactions in the blood stages of malaria Thesis Files
2012 Pettit, Laura J Defining the Clostridium difficile spo0A regulon and its role in disease and transmission Thesis Files
2011 Pettitt, Stephen J Isolation of homozygous mutant mouse embryonic stem cells by selection for copy number increase Thesis Files
2009 Phan, Minh-Duy Analysis of IncHI1 plasmids in Salmonella enterica serovar Typhi Thesis Files
2010 Piipari, Matias Inference and classification of eukaryotic cis-regulatory motifs Thesis Files
2019 Pike, Lindsay Jacqueline Characterising antibiotic susceptibility and resistance in human commensal gut bacteria Thesis Files
2020 Pires de Carvalho Gomes, Tomás Tissue-specific adaptations of cell types Thesis Files
2003 Pocock, Matthew R Computational Analysis of Genomes Thesis Files
2010 Powell, Gareth T The Zebrafish Homologues of JAM-B and JAM-C are Essential for Myoblast Fusion Thesis Files
2011 Protasio, Anna V Transcriptome characterisation of cercariae and skin-stage schistosomula in the parasitic helminth Schistosoma mansoni. Thesis Files
2019 Raddi, Gianmarco Immunity Against Malaria: an Atlas of the Mosquito Cellular Immune System at Single-Cell Resolution Thesis Files
2004 Ramadass, Aroul S Computational detection of gene regulatory signals in human genome sequence Thesis Files
2003 Rand, Vikki Genome Evolution: A study of MHC paralogous genes in the human genome Thesis Files
1999 Reinhardt, Astrid Neural network-based methods for large scale protein sequence analysis. Not available
2018 Riveros Mckay Aguilera, Fernando Genetic studies of cardiometabolic traits Thesis Files
2018 Roberts, Nicola Diane Patterns of somatic genome rearrangement in human cancer Thesis Files
2014 Robles Espinoza, Carla Daniela Drivers of melanoma susceptibility Thesis Files
2008 Rossi, Raffaella Murine embryonic stem cells as a route towards exploring host-pathogen interactions Thesis Files
2019 Rostom, Raghd Human Cellular Genetics of Innate Immunity Not available
2020 Rostom, Raghd Human Cellular Genetics of Innate Immunity Thesis Files
2004 Rustici, Gabriella Periodic gene expression program of the fission yeast cell cycle Thesis Files
2010 Ryan, Tomas Functional investigation of NMDA receptor molecular evolution Not available
2016 Sallah, Neneh The influence of genetics on gamma-herpesvirus infections Thesis Files
2020 Sankar, Aravind Identification of germline variants that predispose to familial melanoma Thesis Files
2009 Santarius, Tom Analysis of gene amplification in human cancer Not available
2019 Sazonovs, Aleksejs The Genetics of IBD: From Susceptibility to Drug Response and Patient Outcome Thesis Files
2008 Schuster-Bockler, Benjamin The role of protein interactions in evolution and disease Thesis Files
2017 Schwartzentruber, Jeremy Using molecular QTLs to identify cell types and causal variants for complex traits Thesis Files
2007 Scott, Annabelle The role of the CapZ complex in vertebrate sarcomere integrity Thesis Files
2017 Sessler, Andreas Florian Transcriptome characterisation of the intra-mammalian stage of male and female Schistosoma mansoni Thesis Files
2018 Shan, Chong Zheng Extracellular receptor-ligand interaction screening using CRISPR activation Thesis Files
2017 Sharma, Sumana Genome-scale identification of cellular pathways required for cell surface recognition Thesis Files
2012 Simpson, Jared Efficient sequence assembly and variant calling using compressed data structures Thesis Files
2017 Singh, Tarjinder The contribution of rare variants to risk of schizophrenia and neurodevelopmental disorders Thesis Files
2000 Smink, Luc Genome studies of human chromosome 22q13.3. Not available
2014 Smith, Sarah The Function and Genetics of the Host IFITM Locus Thesis Files
1996 Sonnhammer, Erik Classification of protein domain families for genomic sequence analysis Not available
2015 Soria, Ximena Ibarra Genetic and environmental regulation of olfactory sensory neurone diversity Thesis Files
2020 Sridhar, Sushmita An integrated approach to ciprofloxacin susceptibility analysis and high-throughput bacterial phenotyping in Salmonella Thesis Files
2002 Stavrides, George Human chromosome 20q12-13.2: Structural, comparative and sequence variation studies Thesis Files
2018 Strege, Katharina Identifying regulators of cytotoxic T cell function through molecular and genetic screening Thesis Files
2007 Sudbery, Ian Methods for genome-scale gene perturbation studies of the TRAIL-induced apoptosis pathway in mammalian cell culture Thesis Files
2016 Szpak, Michal Fine-mapping and functional analyses of genetic variants driving local adaptations in humans Thesis Files
2008 Tam, Gloria Wing Chi Copy Number Variation and Schizophrenia Thesis Files
2014 Tay, Chwen Ling The targets and role of palmitoylation in Plasmodium parasites Thesis Files
2005 Taylor, Amy Molecular characterisation of the candidate region for bronx waltzer: a mouse model of hearing impairment Thesis Files
2005 Thomas, Kevin Analysis of genes controlling notochord development in zebrafish Thesis Files
2003 Thompson, Debrah M Characterization of a Novel Deletion Allele of Brca1 Thesis Files
2020 Tilson, Samantha Grace Induced pluripotent stem cell derived liver model for the study of PNPLA3-associated non-alcoholic fatty liver disease Thesis Files
2007 Tischler, Julia Systematic Analysis of the Evolution and Conservation of Genetic Interactions Using C. elegans as a Model System Thesis Files
2008 Tomazou, Eleni M Identification and Characterisation of Differentially Methylated Regions within the human Major Histocompatibility Complex Thesis Files
2019 Turner, Gemma Application of CRISPR/Cas9 screening to study cancer drivers and to identify novel cancer vulnerabilities Thesis Files
2008 Vernikos, George In silico prediction of Genomic In Islands in microbial genomes Islands Thesis Files
2012 Wanaguru, Madushi Biochemical investigations of Plasmodium falciparum erythrocyte invasion pathways using recombinant merozoite surface proteins produced in a mammalian expression system Thesis Files
2012 Wang, Juexuan Characterization of BCL11 functions in the mouse mammary gland identifies two types of mammary stem cells Not available
2005 Wang, Wei Chromosome-specific Recessive Genetic Screen for Genes Involved in In Vitro Differentiation in Mouse Embyonic Stem Cells Thesis Files
2017 Wangwiwatsin, Arporn Transcriptomic studies on host-parasite interactions in Schistosoma mansoni intramammalian stages Thesis Files
2011 Whitener, Weldon Analysis of short tandem repeat variation in large scale resequencing data Thesis Files
2003 Woodfine, Kathryn Application of DNA Microarrays to Assess DNA Replication Timing and Chromosomal Aberrations Thesis Files
2008 Xiong, Zikai Genome-wide recessive screens for DNA mismatch repair genes in mouse ES cells Thesis Files
2004 Yeats, Corin Biological Investigations through sequence analysis Thesis Files
2012 Yen, Jennifer Progressive hearing loss in mouse mutants Not available
2008 Yngvadottir, Bryndis Evolution by Gene Loss? Thesis Files
2002 Younger, Ruth Identification and analysis of MHC-linked olfactory receptor genes Thesis Files
2013 Zenonos, Zenon Applying recombinant protein technology to study Plasmodium falciparum erythrocyte receptor-ligand interactions and their potential as therapeutic targets Thesis Files
2012 Zhu, Fei Mapping synaptic heterogeneity of MAGUK family members in fluorescent protein knockin mice Not available

MPhil theses

Year Author Title Download
2018 Bett, Vincent Kiplangat Epidemiology and Genomic Diversity of Staphylococcus aureus in Humans and Pigs in Kenya Thesis Files
2017 Bojang, Ebrima Genetic diversity and distribution of the pneumococcal surface lipoproteins and implications on potential proteinbased vaccines Thesis Files
2004 Campbell, Elizabeth A Development of a Resource for the Exploration of Gene Expression in the Mouse Foetus Thesis Files
2017 Cano Gámez, Eddie Characterisation of the transcriptional response to cytokine induced polarisation in human CD4+ T cells and monocyte derived macrophages Thesis Files
2021 Drammeh, Ndey Fatou Role of Plasmodium falciparum genetic backgrounds in tolerance to antimalarial-resistance Thesis Files
2018 Dunstone, Eleanor Identifying mediators of malignant transformation in human cancer using genome-wide forward genetic screening approaches Thesis Files
2011 Harris, Kelley The relationship of identity by state to identity by descent and imputation accuracy in population sequencing data Thesis Files
2011 Hesketh, Richard Phenotypic variation in erythrocyte invasion by Plasmodium falciparum isolates from Peru Thesis Files
2011 Jiang, Ying Overexpression of Mammalian Nanog mRNA Hyperdorsalises Zebrafish Embryos Thesis Files
2017 Le, Tu Thi Phuong Comparative genomics of Escherichia coli causing bloodstream infections in the Hospital for Tropical Diseases, Ho Chi Minh city, Vietnam Thesis Files
2001 Levine, Aaron Bioinformatics approaches to RNA splicing Thesis Files
2017 Mkandawire, Tapoka Thulisile Identification of Extrachromosomal Elements from Whole Genome Sequences of the Human Gut Microbiome to Investigate the Gut Mobilome and Resistome Thesis Files
2018 Mwikali, Kioko RNA sequencing analysis of Plasmodium falciparum extracellular vesicles Thesis Files
2018 Nicola, Pantelis Andreas Somatic mutations in the pancreatic islets Thesis Files
2016 Qarin, Shamma Understanding neurodegenerative diseases in human iPS cell models by genome editing with CRISPR-Cas9 Thesis Files
2003 Riordan, Daniel Bioinformatic Analysis of Imprinted CpG Islands in Mus musculus Thesis Files
2017 Ruiz, Camilo Machine Learning for Precision Oncology: Genomic Classification and Analysis of Diffuse Large B Cell Lymphoma Thesis Files
2018 Thurimella, Kiran Kumar Evaluating the Efficacy of Epigenetic Imputation in CD4+ Regulatory T Cells Thesis Files
2018 Zou, Angela Elizabeth Integrating single-cell transcriptomics with orthogonal experimental approaches and datasets to enhance characterization of the maternal-fetal interface Thesis Files