Dr Michal Szpak | Postdoctoral Fellow

Szpak, Michal

I received my B.Sc. in Biology from the University of Warsaw. My research in the Molecular Archaeology research group focused on ancient DNA analyses, evolutionary genetics and phylogenetics. Subsequently, I conducted my master's degree research at the University of Virginia, Medical School. During that period I was involved in several projects investigating population genetics and human genomics at The Center for Public Health Genomics. I worked on microarray-based CNVs detection and their distribution across 4 ethnic groups. My PhD project in Human Evolution team at the Sanger Institute focused on positive selection in human populations. I work on fine mapping of the adaptive variation for functional follow-up studies. We use genome editing (CRISPR/Cas9) approach to model human evolution in mouse and test hypotheses about selected phenotypes.


  • FineMAV: prioritizing candidate genetic variants driving local adaptations in human populations.

    Szpak M, Mezzavilla M, Ayub Q, Chen Y, Xue Y and Tyler-Smith C

    Genome biology 2018;19;1;5

  • Continuity and Admixture in the Last Five Millennia of Levantine History from Ancient Canaanite and Present-Day Lebanese Genome Sequences.

    Haber M, Doumet-Serhal C, Scheib C, Xue Y, Danecek P et al.

    American journal of human genetics 2017;101;2;274-282

  • Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits.

    Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J et al.

    American journal of human genetics 2017;100;6;865-884

  • Mountain gorilla genomes reveal the impact of long-term population decline and inbreeding.

    Xue Y, Prado-Martinez J, Sudmant PH, Narasimhan V, Ayub Q et al.

    Science (New York, N.Y.) 2015;348;6231;242-245

  • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers.

    Onengut-Gumuscu S, Chen WM, Burren O, Cooper NJ, Quinlan AR et al.

    Nature genetics 2015;47;4;381-6

  • A Selective Sweep on a Deleterious Mutation in CPT1A in Arctic Populations.

    Clemente FJ, Cardona A, Inchley CE, Peter BM, Jacobs G et al.

    American journal of human genetics 2014;95;5;584-589

Szpak, Michal