Howick, Virginia Muriel
I am studying the genetic basis of genotype-by-genotype interactions between the Anopheles vector and the malaria parasite. Using a combination of transcriptomic and genomic data, I aim to identify how specific processes are altered by different vector-parasite combinations.
As an evolutionary biologist, I am generally interested in how individual organisms deal with environmental challenges and perturbations while balancing basic physiological demands. I am interested in the underlying genes and processes that influence these tradeoffs and how selection is acting on these systems, particularly those that relate to host-parasite and vector-parasite interactions. For my Ph.D., I used Drosophila melanogaster as a model system to understand the genetic architecture in immune defence against a bacterial pathogen as resistance and tolerance, and how selection is acting on the innate immune response.
Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila.
Current biology : CB 2016;26;2;257-262
Genotype and diet shape resistance and tolerance across distinct phases of bacterial infection.
BMC evolutionary biology 2014;14;1;56
The genetic architecture of defence as resistance to and tolerance of bacterial infection in Drosophila melanogaster.
Molecular ecology 2017;26;6;1533-1546
Rapid seasonal evolution in innate immunity of wild Drosophila melanogaster.
Proceedings. Biological sciences 2018;285;1870