Peter Campbell | Head of Cancer, Ageing and Somatic Mutation, and Senior Group Leader

Campbell, Peter

peter.campbell@sanger.ac.uk
Cancer Genome Project

Peter Campbell's research programme focuses on the genetic changes our cells acquire as we go through life, and how these mutations are related to ageing, cancer and other disease processes.

My major interest is in cancer genomics, and in particular genome-wide analyses of somatic mutations in tumours. My major areas of interest have been: the discovery of new cancer genes; the identification of somatic mutation processes operative in tumours; the characterisation of patterns of cancer evolution; and the translation of these fundamental insights about cancer biology into better management of patients. I am increasingly interested in the role of somatic mutations outside of cancer. Particular focus areas include how somatic mutations delineate clonal relationships of normal cellular populations and how somatic mutations affect normal cellular behaviour.

Publications

  • Tobacco smoking and somatic mutations in human bronchial epithelium.

    Yoshida K, Gowers KHC, Lee-Six H, Chandrasekharan DP, Coorens T et al.

    Nature 2020;578;7794;266-272

    PUBMED: 31996850; PMC: 7021511; DOI: 10.1038/s41586-020-1961-1

  • Patterns of somatic structural variation in human cancer genomes.

    Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE et al.

    Nature 2020;578;7793;112-121

    PUBMED: 32025012; PMC: 7025897; DOI: 10.1038/s41586-019-1913-9

  • Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.

    Brunner SF, Roberts ND, Wylie LA, Moore L, Aitken SJ et al.

    Nature 2019;574;7779;538-542

    PUBMED: 31645727; PMC: 6837891; DOI: 10.1038/s41586-019-1670-9

  • Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

    Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N et al.

    The New England journal of medicine 2018;379;15;1416-1430

    PUBMED: 30304655; PMC: 7030948; DOI: 10.1056/NEJMoa1716614

  • Population dynamics of normal human blood inferred from somatic mutations.

    Lee-Six H, Øbro NF, Shepherd MS, Grossmann S, Dawson K et al.

    Nature 2018;561;7724;473-478

    PUBMED: 30185910; PMC: 6163040; DOI: 10.1038/s41586-018-0497-0

  • Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

    Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR et al.

    Cell 2018;173;3;611-623.e17

    PUBMED: 29656891; PMC: 5927631; DOI: 10.1016/j.cell.2018.02.020

  • Universal Patterns of Selection in Cancer and Somatic Tissues.

    Martincorena I, Raine KM, Gerstung M, Dawson KJ, Haase K et al.

    Cell 2017;171;5;1029-1041.e21

    PUBMED: 29056346; PMC: 5720395; DOI: 10.1016/j.cell.2017.09.042

  • Precision oncology for acute myeloid leukemia using a knowledge bank approach.

    Gerstung M, Papaemmanuil E, Martincorena I, Bullinger L, Gaidzik VI et al.

    Nature genetics 2017;49;3;332-340

    PUBMED: 28092685; PMC: 5764082; DOI: 10.1038/ng.3756

  • Genomic Classification and Prognosis in Acute Myeloid Leukemia.

    Papaemmanuil E, Gerstung M, Bullinger L, Gaidzik VI, Paschka P et al.

    The New England journal of medicine 2016;374;23;2209-2221

    PUBMED: 27276561; PMC: 4979995; DOI: 10.1056/NEJMoa1516192

  • Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.

    Martincorena I, Roshan A, Gerstung M, Ellis P, Van Loo P et al.

    Science (New York, N.Y.) 2015;348;6237;880-6

    PUBMED: 25999502; PMC: 4471149; DOI: 10.1126/science.aaa6806

  • Subclonal diversification of primary breast cancer revealed by multiregion sequencing.

    Yates LR, Gerstung M, Knappskog S, Desmedt C, Gundem G et al.

    Nature medicine 2015;21;7;751-9

    PUBMED: 26099045; PMC: 4500826; DOI: 10.1038/nm.3886

  • Mobile DNA in cancer. Extensive transduction of nonrepetitive DNA mediated by L1 retrotransposition in cancer genomes.

    Tubio JMC, Li Y, Ju YS, Martincorena I, Cooke SL et al.

    Science (New York, N.Y.) 2014;345;6196;1251343

    PUBMED: 25082706; PMC: 4380235; DOI: 10.1126/science.1251343

  • Recurrent PTPRB and PLCG1 mutations in angiosarcoma.

    Behjati S, Tarpey PS, Sheldon H, Martincorena I, Van Loo P et al.

    Nature genetics 2014;46;4;376-379

    PUBMED: 24633157; PMC: 4032873; DOI: 10.1038/ng.2921

  • RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.

    Papaemmanuil E, Rapado I, Li Y, Potter NE, Wedge DC et al.

    Nature genetics 2014;46;2;116-25

    PUBMED: 24413735; PMC: 3960636; DOI: 10.1038/ng.2874

  • The life history of 21 breast cancers.

    Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD et al.

    Cell 2012;149;5;994-1007

    PUBMED: 22608083; PMC: 3428864; DOI: 10.1016/j.cell.2012.04.023

  • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.

    Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P et al.

    The New England journal of medicine 2011;365;15;1384-95

    PUBMED: 21995386; PMC: 3322589; DOI: 10.1056/NEJMoa1103283

  • Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

    Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR et al.

    Cell 2011;144;1;27-40

    PUBMED: 21215367; PMC: 3065307; DOI: 10.1016/j.cell.2010.11.055

  • The patterns and dynamics of genomic instability in metastatic pancreatic cancer.

    Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED et al.

    Nature 2010;467;7319;1109-13

    PUBMED: 20981101; PMC: 3137369; DOI: 10.1038/nature09460

  • A small-cell lung cancer genome with complex signatures of tobacco exposure.

    Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A et al.

    Nature 2010;463;7278;184-90

    PUBMED: 20016488; PMC: 2880489; DOI: 10.1038/nature08629

  • Targeted sequencing in DLBCL, molecular subtypes, and outcomes: a Haematological Malignancy Research Network report.

    Lacy SE, Barrans SL, Beer P, Painter D, Smith A et al.

    Blood 2020

    PUBMED: 32187361; DOI: 10.1182/blood.2019003535

  • Butler enables rapid cloud-based analysis of thousands of human genomes.

    Yakneen S, Waszak SM, PCAWG Technical Working Group, Gertz M, Korbel JO and PCAWG Consortium

    Nature biotechnology 2020;38;3;288-292

    PUBMED: 32024987; DOI: 10.1038/s41587-019-0360-3

  • Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.

    Cortés-Ciriano I, Lee JJ, Xi R, Jain D, Jung YL et al.

    Nature genetics 2020;52;3;331-341

    PUBMED: 32025003; DOI: 10.1038/s41588-019-0576-7

  • Comprehensive molecular characterization of mitochondrial genomes in human cancers.

    Yuan Y, Ju YS, Kim Y, Li J, Wang Y et al.

    Nature genetics 2020;52;3;342-352

    PUBMED: 32024997; DOI: 10.1038/s41588-019-0557-x

  • Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer.

    Akdemir KC, Le VT, Chandran S, Li Y, Verhaak RG et al.

    Nature genetics 2020;52;3;294-305

    PUBMED: 32024999; DOI: 10.1038/s41588-019-0564-y

  • Pan-cancer analysis of whole genomes identifies driver rearrangements promoted by LINE-1 retrotransposition.

    Rodriguez-Martin B, Alvarez EG, Baez-Ortega A, Zamora J, Supek F et al.

    Nature genetics 2020;52;3;306-319

    PUBMED: 32024998; DOI: 10.1038/s41588-019-0562-0

  • A deep learning system accurately classifies primary and metastatic cancers using passenger mutation patterns.

    Jiao W, Atwal G, Polak P, Karlic R, Cuppen E et al.

    Nature communications 2020;11;1;728

    PUBMED: 32024849; PMC: 7002586; DOI: 10.1038/s41467-019-13825-8

  • Cancer LncRNA Census reveals evidence for deep functional conservation of long noncoding RNAs in tumorigenesis.

    Carlevaro-Fita J, Lanzós A, Feuerbach L, Hong C, Mas-Ponte D et al.

    Communications biology 2020;3;1;56

    PUBMED: 32024996; PMC: 7002399; DOI: 10.1038/s42003-019-0741-7

  • Combined burden and functional impact tests for cancer driver discovery using DriverPower.

    Shuai S, PCAWG Drivers and Functional Interpretation Working Group, Gallinger S, Stein L and PCAWG Consortium

    Nature communications 2020;11;1;734

    PUBMED: 32024818; PMC: 7002750; DOI: 10.1038/s41467-019-13929-1

  • Genomic footprints of activated telomere maintenance mechanisms in cancer.

    Sieverling L, Hong C, Koser SD, Ginsbach P, Kleinheinz K et al.

    Nature communications 2020;11;1;733

    PUBMED: 32024817; PMC: 7002710; DOI: 10.1038/s41467-019-13824-9

  • Integrative pathway enrichment analysis of multivariate omics data.

    Paczkowska M, Barenboim J, Sintupisut N, Fox NS, Zhu H et al.

    Nature communications 2020;11;1;735

    PUBMED: 32024846; PMC: 7002665; DOI: 10.1038/s41467-019-13983-9

  • Pathway and network analysis of more than 2500 whole cancer genomes.

    Reyna MA, Haan D, Paczkowska M, Verbeke LPC, Vazquez M et al.

    Nature communications 2020;11;1;729

    PUBMED: 32024854; PMC: 7002574; DOI: 10.1038/s41467-020-14367-0

  • The evolutionary history of 2,658 cancers.

    Gerstung M, Jolly C, Leshchiner I, Dentro SC, Gonzalez S et al.

    Nature 2020;578;7793;122-128

    PUBMED: 32025013; DOI: 10.1038/s41586-019-1907-7

  • Analyses of non-coding somatic drivers in 2,658 cancer whole genomes.

    Rheinbay E, Nielsen MM, Abascal F, Wala JA, Shapira O et al.

    Nature 2020;578;7793;102-111

    PUBMED: 32025015; PMC: 7054214; DOI: 10.1038/s41586-020-1965-x

  • Pan-cancer analysis of whole genomes.

    ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium

    Nature 2020;578;7793;82-93

    PUBMED: 32025007; PMC: 7025898; DOI: 10.1038/s41586-020-1969-6

  • Patterns of somatic structural variation in human cancer genomes.

    Li Y, Roberts ND, Wala JA, Shapira O, Schumacher SE et al.

    Nature 2020;578;7793;112-121

    PUBMED: 32025012; PMC: 7025897; DOI: 10.1038/s41586-019-1913-9

  • Tobacco smoking and somatic mutations in human bronchial epithelium.

    Yoshida K, Gowers KHC, Lee-Six H, Chandrasekharan DP, Coorens T et al.

    Nature 2020;578;7794;266-272

    PUBMED: 31996850; PMC: 7021511; DOI: 10.1038/s41586-020-1961-1

  • Transcription phenotypes of pancreatic cancer are driven by genomic events during tumor evolution.

    Chan-Seng-Yue M, Kim JC, Wilson GW, Ng K, Figueroa EF et al.

    Nature genetics 2020;52;2;231-240

    PUBMED: 31932696; DOI: 10.1038/s41588-019-0566-9

  • Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies.

    Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T et al.

    Blood 2019;134;24;2195-2208

    PUBMED: 31515253; DOI: 10.1182/blood.2019001553

  • Embryonal precursors of Wilms tumor.

    Coorens THH, Treger TD, Al-Saadi R, Moore L, Tran MGB et al.

    Science (New York, N.Y.) 2019;366;6470;1247-1251

    PUBMED: 31806814; PMC: 6914378; DOI: 10.1126/science.aax1323

  • Genome Sequencing during a Patient's Journey through Cancer.

    Nangalia J and Campbell PJ

    The New England journal of medicine 2019;381;22;2145-2156

    PUBMED: 31774959; DOI: 10.1056/NEJMra1910138

  • The landscape of somatic mutation in normal colorectal epithelial cells.

    Lee-Six H, Olafsson S, Ellis P, Osborne RJ, Sanders MA et al.

    Nature 2019;574;7779;532-537

    PUBMED: 31645730; DOI: 10.1038/s41586-019-1672-7

  • Somatic mutations and clonal dynamics in healthy and cirrhotic human liver.

    Brunner SF, Roberts ND, Wylie LA, Moore L, Aitken SJ et al.

    Nature 2019;574;7779;538-542

    PUBMED: 31645727; PMC: 6837891; DOI: 10.1038/s41586-019-1670-9

  • Genomic landscape and chronological reconstruction of driver events in multiple myeloma.

    Maura F, Bolli N, Angelopoulos N, Dawson KJ, Leongamornlert D et al.

    Nature communications 2019;10;1;3835

    PUBMED: 31444325; PMC: 6707220; DOI: 10.1038/s41467-019-11680-1

  • Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.

    Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C et al.

    Cancer cell 2019;36;2;123-138.e10

    PUBMED: 31303423; PMC: 6863161; DOI: 10.1016/j.ccell.2019.06.007

  • A practical guide for mutational signature analysis in hematological malignancies.

    Maura F, Degasperi A, Nadeu F, Leongamornlert D, Davies H et al.

    Nature communications 2019;10;1;2969

    PUBMED: 31278357; PMC: 6611883; DOI: 10.1038/s41467-019-11037-8

  • TP53 mutation status divides myelodysplastic syndromes with complex karyotypes into distinct prognostic subgroups.

    Haase D, Stevenson KE, Neuberg D, Maciejewski JP, Nazha A et al.

    Leukemia 2019;33;7;1747-1758

    PUBMED: 30635634; PMC: 6609480; DOI: 10.1038/s41375-018-0351-2

  • Integration of transcriptional and mutational data simplifies the stratification of peripheral T-cell lymphoma.

    Maura F, Agnelli L, Leongamornlert D, Bolli N, Chan WC et al.

    American journal of hematology 2019;94;6;628-634

    PUBMED: 30829413; PMC: 6684242; DOI: 10.1002/ajh.25450

  • Single cell analysis of clonal architecture in acute myeloid leukaemia.

    Potter N, Miraki-Moud F, Ermini L, Titley I, Vijayaraghavan G et al.

    Leukemia 2019;33;5;1113-1123

    PUBMED: 30568172; PMC: 6451634; DOI: 10.1038/s41375-018-0319-2

  • Chromosome segregation errors generate a diverse spectrum of simple and complex genomic rearrangements.

    Ly P, Brunner SF, Shoshani O, Kim DH, Lan W et al.

    Nature genetics 2019;51;4;705-715

    PUBMED: 30833795; PMC: 6441390; DOI: 10.1038/s41588-019-0360-8

  • Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML.

    Basheer F, Giotopoulos G, Meduri E, Yun H, Mazan M et al.

    The Journal of experimental medicine 2019;216;4;966-981

    PUBMED: 30890554; PMC: 6446874; DOI: 10.1084/jem.20181276

  • Undifferentiated Sarcomas Develop through Distinct Evolutionary Pathways.

    Steele CD, Tarabichi M, Oukrif D, Webster AP, Ye H et al.

    Cancer cell 2019;35;3;441-456.e8

    PUBMED: 30889380; PMC: 6428691; DOI: 10.1016/j.ccell.2019.02.002

  • Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis.

    Petljak M, Alexandrov LB, Brammeld JS, Price S, Wedge DC et al.

    Cell 2019;176;6;1282-1294.e20

    PUBMED: 30849372; PMC: 6424819; DOI: 10.1016/j.cell.2019.02.012

  • Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

    Teixeira VH, Pipinikas CP, Pennycuick A, Lee-Six H, Chandrasekharan D et al.

    Nature medicine 2019;25;3;517-525

    PUBMED: 30664780; DOI: 10.1038/s41591-018-0323-0

  • Recurrent histone mutations in T-cell acute lymphoblastic leukaemia.

    Collord G, Martincorena I, Young MD, Foroni L, Bolli N et al.

    British journal of haematology 2019;184;4;676-679

    PUBMED: 29602208; PMC: 6766952; DOI: 10.1111/bjh.15155

  • COSMIC: the Catalogue Of Somatic Mutations In Cancer.

    Tate JG, Bamford S, Jubb HC, Sondka Z, Beare DM et al.

    Nucleic acids research 2019;47;D1;D941-D947

    PUBMED: 30371878; PMC: 6323903; DOI: 10.1093/nar/gky1015

  • Integrative Molecular Characterization of Malignant Pleural Mesothelioma.

    Hmeljak J, Sanchez-Vega F, Hoadley KA, Shih J, Stewart C et al.

    Cancer discovery 2018;8;12;1548-1565

    PUBMED: 30322867; PMC: 6310008; DOI: 10.1158/2159-8290.CD-18-0804

  • Neutral tumor evolution?

    Tarabichi M, Martincorena I, Gerstung M, Leroi AM, Markowetz F et al.

    Nature genetics 2018;50;12;1630-1633

    PUBMED: 30374075; PMC: 6548558; DOI: 10.1038/s41588-018-0258-x

  • Somatic mutant clones colonize the human esophagus with age.

    Martincorena I, Fowler JC, Wabik A, Lawson ARJ, Abascal F et al.

    Science (New York, N.Y.) 2018;362;6417;911-917

    PUBMED: 30337457; PMC: 6298579; DOI: 10.1126/science.aau3879

  • Classification and Personalized Prognosis in Myeloproliferative Neoplasms.

    Grinfeld J, Nangalia J, Baxter EJ, Wedge DC, Angelopoulos N et al.

    The New England journal of medicine 2018;379;15;1416-1430

    PUBMED: 30304655; PMC: 7030948; DOI: 10.1056/NEJMoa1716614

  • Population dynamics of normal human blood inferred from somatic mutations.

    Lee-Six H, Øbro NF, Shepherd MS, Grossmann S, Dawson K et al.

    Nature 2018;561;7724;473-478

    PUBMED: 30185910; PMC: 6163040; DOI: 10.1038/s41586-018-0497-0

  • Rearrangement bursts generate canonical gene fusions in bone and soft tissue tumors.

    Anderson ND, de Borja R, Young MD, Fuligni F, Rosic A et al.

    Science (New York, N.Y.) 2018;361;6405

    PUBMED: 30166462; PMC: 6176908; DOI: 10.1126/science.aam8419

  • Hydroxycarbamide Plus Aspirin Versus Aspirin Alone in Patients With Essential Thrombocythemia Age 40 to 59 Years Without High-Risk Features.

    Godfrey AL, Campbell PJ, MacLean C, Buck G, Cook J et al.

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018;JCO2018788414

    PUBMED: 30153096; PMC: 6269131; DOI: 10.1200/JCO.2018.78.8414

  • Genomic patterns of progression in smoldering multiple myeloma.

    Bolli N, Maura F, Minvielle S, Gloznik D, Szalat R et al.

    Nature communications 2018;9;1;3363

    PUBMED: 30135448; PMC: 6105687; DOI: 10.1038/s41467-018-05058-y

  • Prediction of acute myeloid leukaemia risk in healthy individuals.

    Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N et al.

    Nature 2018;559;7714;400-404

    PUBMED: 29988082; PMC: 6485381; DOI: 10.1038/s41586-018-0317-6

  • Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

    Wegert J, Vokuhl C, Collord G, Del Castillo Velasco-Herrera M, Farndon SJ et al.

    Nature communications 2018;9;1;2378

    PUBMED: 29915264; PMC: 6006309; DOI: 10.1038/s41467-018-04650-6

  • Recurrent rearrangements of FOS and FOSB define osteoblastoma.

    Fittall MW, Mifsud W, Pillay N, Ye H, Strobl AC et al.

    Nature communications 2018;9;1;2150

    PUBMED: 29858576; PMC: 5984627; DOI: 10.1038/s41467-018-04530-z

  • Mutational signatures of DNA mismatch repair deficiency in C. elegans and human cancers.

    Meier B, Volkova NV, Hong Y, Schofield P, Campbell PJ et al.

    Genome research 2018;28;5;666-675

    PUBMED: 29636374; PMC: 5932607; DOI: 10.1101/gr.226845.117

  • Deterministic Evolutionary Trajectories Influence Primary Tumor Growth: TRACERx Renal.

    Turajlic S, Xu H, Litchfield K, Rowan A, Horswell S et al.

    Cell 2018;173;3;595-610.e11

    PUBMED: 29656894; PMC: 5938372; DOI: 10.1016/j.cell.2018.03.043

  • Timing the Landmark Events in the Evolution of Clear Cell Renal Cell Cancer: TRACERx Renal.

    Mitchell TJ, Turajlic S, Rowan A, Nicol D, Farmery JHR et al.

    Cell 2018;173;3;611-623.e17

    PUBMED: 29656891; PMC: 5927631; DOI: 10.1016/j.cell.2018.02.020

  • Biological and prognostic impact of APOBEC-induced mutations in the spectrum of plasma cell dyscrasias and multiple myeloma cell lines.

    Maura F, Petljak M, Lionetti M, Cifola I, Liang W et al.

    Leukemia 2018;32;4;1044-1048

    PUBMED: 29209044; PMC: 5886048; DOI: 10.1038/leu.2017.345

  • Intra-tumour diversification in colorectal cancer at the single-cell level.

    Roerink SF, Sasaki N, Lee-Six H, Young MD, Alexandrov LB et al.

    Nature 2018;556;7702;457-462

    PUBMED: 29643510; DOI: 10.1038/s41586-018-0024-3

  • SvABA: genome-wide detection of structural variants and indels by local assembly.

    Wala JA, Bandopadhayay P, Greenwald NF, O'Rourke R, Sharpe T et al.

    Genome research 2018;28;4;581-591

    PUBMED: 29535149; PMC: 5880247; DOI: 10.1101/gr.221028.117

  • A Distinct Class of Genome Rearrangements Driven by Heterologous Recombination.

    León-Ortiz AM, Panier S, Sarek G, Vannier JB, Patel H et al.

    Molecular cell 2018;69;2;292-305.e6

    PUBMED: 29351848; PMC: 5783719; DOI: 10.1016/j.molcel.2017.12.014

  • The European Society for Medical Oncology (ESMO) Precision Medicine Glossary.

    Yates LR, Seoane J, Le Tourneau C, Siu LL, Marais R et al.

    Annals of oncology : official journal of the European Society for Medical Oncology 2018;29;1;30-35

    PUBMED: 29140430; DOI: 10.1093/annonc/mdx707

  • Universal Patterns of Selection in Cancer and Somatic Tissues.

    Martincorena I, Raine KM, Gerstung M, Dawson KJ, Haase K et al.

    Cell 2017;171;5;1029-1041.e21

    PUBMED: 29056346; PMC: 5720395; DOI: 10.1016/j.cell.2017.09.042

  • Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors.

    Cheng J, Demeulemeester J, Wedge DC, Vollan HKM, Pitt JJ et al.

    Nature communications 2017;8;1;1221

    PUBMED: 29089486; PMC: 5663922; DOI: 10.1038/s41467-017-01355-0

  • The driver landscape of sporadic chordoma.

    Tarpey PS, Behjati S, Young MD, Martincorena I, Alexandrov LB et al.

    Nature communications 2017;8;1;890

    PUBMED: 29026114; PMC: 5638846; DOI: 10.1038/s41467-017-01026-0

  • Next-generation sequencing of a family with a high penetrance of monoclonal gammopathies for the identification of candidate risk alleles.

    Bolli N, Barcella M, Salvi E, D'Avila F, Vendramin A et al.

    Cancer 2017;123;19;3701-3708

    PUBMED: 28542843; DOI: 10.1002/cncr.30777

  • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells.

    Roumeliotis TI, Williams SP, Gonçalves E, Alsinet C, Del Castillo Velasco-Herrera M et al.

    Cell reports 2017;20;9;2201-2214

    PUBMED: 28854368; PMC: 5583477; DOI: 10.1016/j.celrep.2017.08.010

  • Cliques and Schisms of Cancer Genes.

    Campbell PJ

    Cancer cell 2017;32;2;129-130

    PUBMED: 28810139; DOI: 10.1016/j.ccell.2017.07.009

  • Genomic Evolution of Breast Cancer Metastasis and Relapse.

    Yates LR, Knappskog S, Wedge D, Farmery JHR, Gonzalez S et al.

    Cancer cell 2017;32;2;169-184.e7

    PUBMED: 28810143; PMC: 5559645; DOI: 10.1016/j.ccell.2017.07.005

  • Integrative Genomics Identifies the Molecular Basis of Resistance to Azacitidine Therapy in Myelodysplastic Syndromes.

    Unnikrishnan A, Papaemmanuil E, Beck D, Deshpande NP, Verma A et al.

    Cell reports 2017;20;3;572-585

    PUBMED: 28723562; DOI: 10.1016/j.celrep.2017.06.067

  • Recurrent mutation of IGF signalling genes and distinct patterns of genomic rearrangement in osteosarcoma.

    Behjati S, Tarpey PS, Haase K, Ye H, Young MD et al.

    Nature communications 2017;8;15936

    PUBMED: 28643781; PMC: 5490007; DOI: 10.1038/ncomms15936

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    eLife 2013;2;e00534

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  • Aberrant 3' oligoadenylation of spliceosomal U6 small nuclear RNA in poikiloderma with neutropenia.

    Hilcenko C, Simpson PJ, Finch AJ, Bowler FR, Churcher MJ et al.

    Blood 2013;121;6;1028-38

    PUBMED: 23190533; DOI: 10.1182/blood-2012-10-461491

  • Deciphering signatures of mutational processes operative in human cancer.

    Alexandrov LB, Nik-Zainal S, Wedge DC, Campbell PJ and Stratton MR

    Cell reports 2013;3;1;246-59

    PUBMED: 23318258; PMC: 3588146; DOI: 10.1016/j.celrep.2012.12.008

  • The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models.

    Yen J, White RM, Wedge DC, Van Loo P, de Ridder J et al.

    Genome biology 2013;14;10;R113

    PUBMED: 24148783; PMC: 3983654; DOI: 10.1186/gb-2013-14-10-r113

  • Next-generation sequencing in breast cancer: first take home messages.

    Desmedt C, Voet T, Sotiriou C and Campbell PJ

    Current opinion in oncology 2012;24;6;597-604

    PUBMED: 23014189; PMC: 3713550; DOI: 10.1097/CCO.0b013e328359554e

  • JAK2V617F homozygosity arises commonly and recurrently in PV and ET, but PV is characterized by expansion of a dominant homozygous subclone.

    Godfrey AL, Chen E, Pagano F, Ortmann CA, Silber Y et al.

    Blood 2012;120;13;2704-7

    PUBMED: 22898600; PMC: 3672970; DOI: 10.1182/blood-2012-05-431791

  • LRP1B deletion in high-grade serous ovarian cancers is associated with acquired chemotherapy resistance to liposomal doxorubicin.

    Cowin PA, George J, Fereday S, Loehrer E, Van Loo P et al.

    Cancer research 2012;72;16;4060-73

    PUBMED: 22896685; DOI: 10.1158/0008-5472.CAN-12-0203

  • The life history of 21 breast cancers.

    Nik-Zainal S, Van Loo P, Wedge DC, Alexandrov LB, Greenman CD et al.

    Cell 2012;149;5;994-1007

    PUBMED: 22608083; PMC: 3428864; DOI: 10.1016/j.cell.2012.04.023

  • The landscape of cancer genes and mutational processes in breast cancer.

    Stephens PJ, Tarpey PS, Davies H, Van Loo P, Greenman C et al.

    Nature 2012;486;7403;400-4

    PUBMED: 22722201; PMC: 3428862; DOI: 10.1038/nature11017

  • Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts.

    Papaemmanuil E, Cazzola M, Boultwood J, Malcovati L, Vyas P et al.

    The New England journal of medicine 2011;365;15;1384-95

    PUBMED: 21995386; PMC: 3322589; DOI: 10.1056/NEJMoa1103283

  • Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

    Varela I, Tarpey P, Raine K, Huang D, Ong CK et al.

    Nature 2011;469;7331;539-42

    PUBMED: 21248752; PMC: 3030920; DOI: 10.1038/nature09639

  • Massive genomic rearrangement acquired in a single catastrophic event during cancer development.

    Stephens PJ, Greenman CD, Fu B, Yang F, Bignell GR et al.

    Cell 2011;144;1;27-40

    PUBMED: 21215367; PMC: 3065307; DOI: 10.1016/j.cell.2010.11.055

  • The patterns and dynamics of genomic instability in metastatic pancreatic cancer.

    Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED et al.

    Nature 2010;467;7319;1109-13

    PUBMED: 20981101; PMC: 3137369; DOI: 10.1038/nature09460

  • International network of cancer genome projects.

    International Cancer Genome Consortium, Hudson TJ, Anderson W, Artez A, Barker AD et al.

    Nature 2010;464;7291;993-8

    PUBMED: 20393554; PMC: 2902243; DOI: 10.1038/nature08987

  • Origins and functional impact of copy number variation in the human genome.

    Conrad DF, Pinto D, Redon R, Feuk L, Gokcumen O et al.

    Nature 2010;464;7289;704-12

    PUBMED: 19812545; PMC: 3330748; DOI: 10.1038/nature08516

  • Signatures of mutation and selection in the cancer genome.

    Bignell GR, Greenman CD, Davies H, Butler AP, Edkins S et al.

    Nature 2010;463;7283;893-8

    PUBMED: 20164919; PMC: 3145113; DOI: 10.1038/nature08768

  • Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.

    Dalgliesh GL, Furge K, Greenman C, Chen L, Bignell G et al.

    Nature 2010;463;7279;360-3

    PUBMED: 20054297; PMC: 2820242; DOI: 10.1038/nature08672

  • A comprehensive catalogue of somatic mutations from a human cancer genome.

    Pleasance ED, Cheetham RK, Stephens PJ, McBride DJ, Humphray SJ et al.

    Nature 2010;463;7278;191-6

    PUBMED: 20016485; PMC: 3145108; DOI: 10.1038/nature08658

  • A small-cell lung cancer genome with complex signatures of tobacco exposure.

    Pleasance ED, Stephens PJ, O'Meara S, McBride DJ, Meynert A et al.

    Nature 2010;463;7278;184-90

    PUBMED: 20016488; PMC: 2880489; DOI: 10.1038/nature08629

  • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer.

    van Haaften G, Dalgliesh GL, Davies H, Chen L, Bignell G et al.

    Nature genetics 2009;41;5;521-3

    PUBMED: 19330029; PMC: 2873835; DOI: 10.1038/ng.349

  • The cancer genome.

    Stratton MR, Campbell PJ and Futreal PA

    Nature 2009;458;7239;719-24

    PUBMED: 19360079; PMC: 2821689; DOI: 10.1038/nature07943

  • Somatic and germline genetics at the JAK2 locus.

    Campbell PJ

    Nature genetics 2009;41;4;385-6

    PUBMED: 19338077

  • Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing.

    Campbell PJ, Pleasance ED, Stephens PJ, Dicks E, Rance R et al.

    Proceedings of the National Academy of Sciences of the United States of America 2008;105;35;13081-6

    PUBMED: 18723673; PMC: 2529122; DOI: 10.1073/pnas.0801523105

  • Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing.

    Campbell PJ, Stephens PJ, Pleasance ED, O'Meara S, Li H et al.

    Nature genetics 2008;40;6;722-9

    PUBMED: 18438408; PMC: 2705838; DOI: 10.1038/ng.128

  • Chromosomally unstable mouse tumours have genomic alterations similar to diverse human cancers.

    Maser RS, Choudhury B, Campbell PJ, Feng B, Wong KK et al.

    Nature 2007;447;7147;966-71

    PUBMED: 17515920; PMC: 2714968; DOI: 10.1038/nature05886

  • Patterns of somatic mutation in human cancer genomes.

    Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C et al.

    Nature 2007;446;7132;153-8

    PUBMED: 17344846; PMC: 2712719; DOI: 10.1038/nature05610

  • An acquired translocation in JAK2 Val617Phe-negative essential thrombocythemia associated with autosomal spread of X-inactivation.

    Vassiliou GS, Campbell PJ, Li J, Roberts I, Swanton S et al.

    Haematologica 2006;91;8;1100-4

    PUBMED: 16885051

  • Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study.

    Campbell PJ, Scott LM, Buck G, Wheatley K, East CL et al.

    Lancet (London, England) 2005;366;9501;1945-53

    PUBMED: 16325696; DOI: 10.1016/S0140-6736(05)67785-9

  • Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders.

    Baxter EJ, Scott LM, Campbell PJ, East C, Fourouclas N et al.

    Lancet (London, England) 2005;365;9464;1054-61

    PUBMED: 15781101; DOI: 10.1016/S0140-6736(05)71142-9

Campbell, Peter

Related Programmes, Associate Research Programmes and Facilities

Peter's Timeline
2010

Group Leader, Wellcome Trust Sanger Institute

2007

Post-doctoral fellowship, Sanger Institute

2003

PhD studentship, University of Cambridge

2000

Clinical Haematology specialist training