Dr Meg Byrne, EngD | Senior Research Assistant

Byrne, Meg

Using CRISPR-Cas technologies to modify targeted loci in iPS cells for use in studying disease.  Particular focus on modifications associated with neurodegenerative diseases (Parkinsons and Alzheimers).

Publications

  • Editing the Genome of Human Induced Pluripotent Stem Cells Using CRISPR/Cas9 Ribonucleoprotein Complexes.

    Bruntraeger M, Byrne M, Long K and Bassett AR

    Methods in molecular biology (Clifton, N.J.) 2019;1961;153-183

  • Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

    Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G et al.

    Stem cell research 2013;11;3;1206-21

  • Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts.

    Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB and Caldwell MA

    Regenerative medicine 2012;7;5;675-83

  • Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing.

    Prior S, Fleck RA, Gillett ML, Rigsby PR, Corbel MJ et al.

    Vaccine 2006;24;22;4794-803

  • Editing the Genome of Human Induced Pluripotent Stem Cells Using CRISPR/Cas9 Ribonucleoprotein Complexes.

    Bruntraeger M, Byrne M, Long K and Bassett AR

    Methods in molecular biology (Clifton, N.J.) 2019;1961;153-183

  • Stepwise, non-adherent differentiation of human pluripotent stem cells to generate basal forebrain cholinergic neurons via hedgehog signaling.

    Crompton LA, Byrne ML, Taylor H, Kerrigan TL, Bru-Mercier G et al.

    Stem cell research 2013;11;3;1206-21

  • Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts.

    Badger JL, Byrne ML, Veraitch FS, Mason C, Wall IB and Caldwell MA

    Regenerative medicine 2012;7;5;675-83

  • Evaluation of adenyl cyclase toxin constructs from Bordetella pertussis as candidate vaccine components in an in vitro model of complement-dependent intraphagocytic killing.

    Prior S, Fleck RA, Gillett ML, Rigsby PR, Corbel MJ et al.

    Vaccine 2006;24;22;4794-803

Byrne, Meg