Staff PhD and MPhil theses - Wellcome Sanger Institute

Staff PhD and MPhil theses in pdf format

Staff PhD theses can be download here. The first link goes to a directory containing a set of PDF files of the thesis, the second a compressed TAR file of these pdfs.

PhD Theses

Title	Author	Year	Thesis
Identification and Characterisation of Regulatory Elements on Human Chromosome 20q12-13.2	Akan, Pelin	2006	Pelin Akan's thesis tar.gz file
Regulation of gene expression in macrophage immune response	Alasoo, Kaur	2016	Kaur Alasoo's thesis tar.gz file
Signatures of Mutational Processes in Human Cancer	Alexandrov, Ludmil	2014	Ludmil Alexandrov's thesis tar.gz file
Integrated approaches to elucidate the genetic architecture of congenital heart defects	Al Turki, Saeed	2013	Saeed Al Turki's thesis tar.gz file
Simian Immunodeficiency Virus Infection of CD4+ T Cell Subsets and Its Impact on B Cell Responses in Early Infection	Archer, Eva Jacqueline	2016	Eva Jacqueline Archer's thesis tar.gz file
De novo assembly of the var multi-gene family in clinical samples of Plasmodium falciparum	Assefa, Sammy	2013	Sammy Assefa's thesis tar.gz file
Studies of the effects of promoter sequence variation on gene expression in human chromosome 22	Bacha, Jamil	2006	Jamil Bacha's thesis tar.gz file
High-throughput Experimental and Computational Studies of Bacterial Evolution	Barquist, Lars	2013	Lars Barquist's thesis tar.gz file
Gene identification and characterisation on the human X chromosome	Barrett, Ian	2004	Ian Barrett's thesis tar.gz file
Analysing the B-cell repertoire: Investigating B-cell population dynamics in health and disease.	Bashford-Rogers, Rachael	2014	Rachael Bashford-Rogers' thesis tar.gz file
Genomic insights into the human population history of Australia and New Guinea	Bergström, Anders	2017	Anders Bergström's thesis tar.gz file
The evolution of functional non-coding DNA in humans	Bird, Christine	2010	Not available
Sequence alignment in bioinformatics.	Birney, Ewan	2000	Not available
Survey of RNA editing in the human brain	Blow, Matthew J	2004	Matthew J Blow's thesis tar.gz file
Development of computational methods for analysing proteomic data for genome annotation	Brosch, Markus	2009	Markus Brosch's thesis tar.gz file
Evolutionary Genomics of Pathogenic Mycobacteria	Bryant, Josephine M	2014	Josephine M Bryant's thesis tar.gz file
Mechanisms of change in protein architecture	Buljan, Marija	2010	Marija Buljan's thesis tar.gz file
Rearrangement breakpoints and viral integration sites in the human genome	Burford, Deborah	2007	Deborah Burford's thesis tar.gz file
Uncovering the role of common and rare variants in migraine	Calafato, Stella	2012	Stella Calafato's thesis tar.gz file
Identifying and modelling genes that are associated with rare developmental disorders	Carss, Keren	2014	Keren Carss' thesis tar.gz file
Evolution of Streptococcus pneumoniae during carriage	Chewapreecha, Claire	2014	Claire Chewapreecha's thesis tar.gz file
Genetics of the anticoagulant drug warfarin	Chen, Yen-Yu (Leslie)	2007	Yen-Yu (Leslie) Chen's thesis tar.gz file
The role of transcription factor GATA6 in the development of the human pancreas	Chia, Crystal Ying	2017	Crystal Ying Chia's thesis tar.gz file
Physical mapping on the human X chromosome and its application to the positional cloning of the XLP gene	Coffey, Alison J	2000	Not available
Protein Domains: New methods for detection and evolutionary analysis	Coin, Lachlan	2005	Lachlan Coin's thesis tar.gz file
The physical map of the genome of Caenorhabditis elegans	Coulson, Alan	1994	Not available
Functional and evolutionary analyses of pneumococcal genome variation	Croucher, Nicholas	2011	Nicholas Croucher's thesis tar.gz file
Role of Synapse-Associated Protein 102 in Postsynaptic Signalling, Synaptic Plasticity and Learning	Cuthbert, Peter	2005	Peter Cuthbert's thesis tar.gz file
The diversity of disease-causing and environmental Legionella pneumophila	David, Sophia	2016	Sophia David's thesis tar.gz file
Generation of a murine ES cell system deficient in microRNA processing for the identification of microRNA targets	Davis, Matthew	2009	Matthew Davis' thesis tar.gz file
Chromosomal imbalances in colorectal cancer	Davison, Eleanor	2004	Not available
Understanding inflammatory bowel disease using high-throughput sequencing	de Lange, Katrina Melanie	2017	Katrina Melanie de Lange's thesis tar.gz file
The SCL Gene and Transcriptional Control of Haematopoiesis	Dhami, Pawandeep	2005	Pawandeep Dhami's thesis tar.gz file
Development of Chromatin Immuniprecipitation Microarray Technology for the Identification of Regulatory Elements in the Human Genome	Dillon, Shane	2008	Shane Dillon's thesis tar.gz file
The role of regulatory variation in sculpting gene expression across human populations and cell types	Dimas, Antigone	2009	Antigone Dimas' thesis tar.gz file
The Genetics of Cellular Phenotypes	Ding, Zhihao	2014	Zhihao Ding's thesis tar.gz file
Motif based computational identification of protein subcellular localisation	Dogruel, Mutlu	2008	Mutlu Dogruel's thesis tar.gz file
Computational localization of promoters and transcription start sites in mammalian genomes	Down, Thomas	2003	Thomas Down's thesis tar.gz file
Studies on the development and organisation of the nervous system of Caenorhabditis elegans	Durbin, Richard	1987	Richard Durbin's thesis tar.gz file
An Analysis of Transcript Variation in Human Xp11.23	Eades, Tamsin L	2005	Tamsin L Eades' thesis tar.gz file
Classification of protein domain families for genomic sequence analysis	Erik, Sonnhammer	1996	Not available
Drivers of melanoma susceptibility	Espinoza, Carla	2014	Carla Espinoza's thesis tar.gz file
Investigating the Role of Interferon-Inducible Transmembrane 3 (IFITM3) in Infection.	Everitt, Aaron	2013	Aaron Everitt's thesis tar.gz file
Genetic Studies of Syndromes of Severe Insulin Resistance and Type 2 Diabetes: a candidate gene approach	Fawcett, Katherine	2008	Katherine Fawcett's thesis tar.gz file
High-throughput reverse genetic screening in Plasmodium berghei using barcode sequencing	Gomes, Ana Rita Batista	2014	Ana Rita Batista Gomes' thesis tar.gz file
Understanding human disease using high-throughput sequencing	Goncalves Serra, Eva	2016	Eva Goncalves Serra's thesis tar.gz file
Structural, functional and comparative studies of human chromosome 22q13.31	Goward, Melanie	2002	Melanie Goward's thesis tar.gz file
Chromosome 1 map, sequence and variation	Gregory, Simon	2003	Simon Gregory's thesis tar.gz file
A Study of Molecular Synergy and Clonal Evolution in Haematopoietic Malignancies	Grove, Carolyn	2014	Carolyn Grove's thesis tar.gz file
Recessive genetic screen for mismatch repair components in BLM-deficient ES cells	Guo, Ge	2004	Ge Guo's thesis tar.gz file
Finding genes involved in corneal endothelial dystrophies linked to human chromosome 20	Gwilliam, Rhian	2004	Not available
Computational Detection and Analysis of Polyadenylation Signals	Hajarnavis, Ashwin	2005	Ashwin Hajarnavis' thesis tar.gz file
Phenotypic and Functional Characterisation of Innate and Adaptive Immune Responses after Mucosal Vaccination	Hall, Lindsay	2007	Lindsay Hall's thesis tar.gz file
Prediction and analysis of nucleosome positioning in genomic sequences	Hasan, Samiul	2003	Samiul Hasan's thesis tar.gz file
Genomic variation and evolution of Clostridium difficile	He, Miao	2011	Miao He's thesis tar.gz file
DNA polymerase mutations as drivers of genome instability and cancer	Herzog, Mareike	2016	Mareike Herzog's thesis tar.gz file
A functional genomic-based study of the streptomycin mouse model of human Salmonella Typhimurium gastroenteritis	Hill, Jennifer	2015	Jennifer Hill's thesis tar.gz file
Progressive hearing loss in mouse mutants	Hilton, Jennifer	2012	Not available
Studies in probabilistic sequence alignment and evolution	Holmes, Ian	1998	Ian Holmes' thesis tar.gz file
Genomic variation and evolution of Salmonella enterica serovars Typhi and Paratyphi A	Holt, Kathryn	2009	Kathryn Holt's thesis tar.gz file
Identification of novel Plasmodium Vivax blood-stage vaccine targets	Hostetler, Jessica Blythe	2016	Jessica Blythe Hostetler's thesis tar.gz file
Gene prediction using a configurable system for the integration of data by Dynamic programming	Howe, Kevin	2003	Kevin Howe's thesis tar.gz file
Physical, transcriptional and comparative mapping on the human X chromosome	Howell, Gareth	2002	Gareth Howell's thesis tar.gz file
Positive natural selection in the human genome	Hu, Min	2012	Min Hu's thesis tar.gz file
Whole-genome Sequencing-based Association Studies of Cardiovascular Biomarkers	Huang, Jie	2015	Jie Huang's thesis tar.gz file
The functional impact of copy number variation in the human genome	Huang, Ni	2011	Ni Huang's thesis tar.gz file
Computational detection of non-coding RNAs in genomes	Huang, Yen-Hua	2008	Yen-Hua Huang's thesis tar.gz file
Genome plasticity and genetic exchange in Leishmania tropica	Iantorno, Stefano	2015	Stefano Iantorno's thesis tar.gz file
Characterization of Cancer Gene Mutations in Human Cancer Cell lines for Correlation with Drug Activity	Ikediobi, Ogechi	2008	Ogechi Ikediobi's thesis tar.gz file
Identification of target genes of an erythroid transcription factor complex containing SCL(TAL1)	Jim, Hau Ling	2008	Hau Ling Jim's thesis tar.gz file
A role for microRNA-155 in the control of infection	John, Victoria	2010	Victoria John's thesis tar.gz file
Computational analysis of the Caenorhabditis elegans genome sequence	Jones, Steve	1999	Not available
Genetic and phenotypic investigations into developmental disorders	Jones, Wendy Dawn	2017	Wendy Dawn Jones' thesis tar.gz file
Using Next-Generation Genomic Datasets In Disease Association	Jostins, Luke	2012	Luke Jostins' thesis tar.gz file
Molecular characterization and computational analysis of constitutional chromosome rearrangements	Kalaitzopoulos, Dimitrios	2006	Not available
Identification of Genetic Differences Between Strains of Campylobacter jejuni	Kay, Emily	2005	Emily Kay's thesis tar.gz file
Investigations into the Rab family of genes and their roles in signalling during vertebrate early development	Kenyon, Emma	2006	Emma Kenyon's thesis tar.gz file
Uniparental disomy and mosaic structural variation in developmental disorders	King, Daniel Alexander	2015	Daniel Alexander King's thesis tar.gz file
Single cell mRNA-sequencing of mESCs reveals cell-to-cell variation in pluripotency and cell cycle genes	Kolodziejczyk, Aleksandra Anna	2016	Aleksandra Anna Kolodziejczyk's thesis tar.gz file
Transposon-mediated Insertional Mutagenesis in Gene Discovery and Cancer	Kong, Jun	2011	Jun Kong's thesis tar.gz file
Genome-Wide Translational Control In Fission Yeast	Lackner, Daniel	2007	Daniel Lackner's thesis tar.gz file
The ribosomal RNA processing gene nucleolar protein 9 (nol9) is essential for normal exocrine pancreas development in zebrafish	Lam Hung, Laure	2013	Laure Lam Hung's thesis tar.gz file
Karyotype Evolution: Evolutionary Chromosome Rearrangements in Material Homologous to Human Chromosome 22q Studied in the Dog and Gibbon	Langford, Cordelia	2003	Cordelia Langford's thesis tar.gz file
Metabolic capability in host-restricted serovars of Salmonella enterica	Langridge, Gemma C	2010	Gemma C Langridge's thesis tar.gz file
Characterisation of bcl11 functions in development using genetically modified mice	Lee, Song Choon	2008	Song Choon Lee's thesis tar.gz file
Host and pathogen genetics associated with pneumococcal meningitis	Lees, John Andrew	2017	John Andrew Lees' thesis tar.gz file
A genetic screen for tumour suppressor genes using the sleeping beauty and piggybac transposon systems	Liang, Qi	2009	Not available
A recessive genetic screen to discover components in miRNA pathways using piggyBac-mediated insertional mutagenesis in Blm-deficient mouse embryonic stem cells	Li, Meng	2010	Meng Li's thesis tar.gz file
Reprogramming of T cells to natural killer-like cells upon BCL11B deletion	Li, Peng	2010	Peng Li's thesis tar.gz file
The genetic architecture of immune-mediated complex diseases	Liu, Jimmy	2014	Jimmy Liu's thesis tar.gz file
Evolutionary Landscape of CpG Island Methylation in X Chromosome Inactivation	Liu, Mengning	2008	Mengning Liu's thesis tar.gz file
Identification and Functional Characterisation of a Genetic Subset of Non-Small Cell Lung Cancer	Mahoney, Claire	2009	Claire Mahoney's thesis tar.gz file
Genomic diversity and speciation in East African cichlid fish	Malinsky, Milan	2015	Milan Malinsky's thesis tar.gz file
The role of microRNAs in neurons - (Also known as Sergei A Manakov)	Manakou, Siarhei	2011	Siarhei Manakou's thesis tar.gz file
Analysis of genome-wide, cancer-associated mutation datasets in mouse and human	Mattison, Jenny	2008	Jenny Mattison's thesis tar.gz file
Schizosaccharomyces pombe: from sequence to function	McDougall, Rachel C	1997	Not available
Mathematical methods for comparative ab initio gene prediction	Meyer, Imtraud	2002	Imtraud Meyer's thesis tar.gz file
Modelling Human Genetic Disorders in Mice	Migdalska, Anna	2011	Anna Migdalska's thesis tar.gz file
Analysis of genetic variation data using Ancestral Recombination Graphs	Minichiello, Mark	2007	Mark Minichiello's thesis tar.gz file
Evolution and gene regulation of the genomic imprinting mechanism	Mungall, Andy	2007	Andy Mungall's thesis tar.gz file
The Origins and Evolution of Vibrio cholerae O1 El Tor	Mutreja, Ankur	2014	Ankur Mutreja's thesis tar.gz file
Analysis of the transcriptomes of wild-type and mutant C. elegans	Nelson, Andrew	2008	Andrew Nelson's thesis tar.gz file
Regulatory variation and its role in disease	Nica, Alexandra C	2010	Alexandra C Nica's thesis tar.gz file
Exploring mutational signatures in twenty-one breast cancers	Nik-Zainal, Serena	2012	Serena Nik-Zainal's thesis tar.gz file
The Role of Retinoic Acid Receptors in the Replacement of Oct4 during the Generation of Induced Pluripotent Stem Cells	Ooi, Jolene	2012	Jolene Ooi's thesis tar.gz file
Genetic mapping of cellular traits	Parts, Leopold	2011	Leopold Parts' thesis tar.gz file
Maps of open chromatin - from genetic signals to function	Paul, Dirk	2012	Dirk Paul's thesis tar.gz file
Characterisation of the Transcriptome and Proteome of Salmonella enterica subspecies enterica serovar Typhi	Perkins, Timothy	2009	Timothy Perkins' thesis tar.gz file
Identification and characterisation of host-pathogen protein-protein interactions in the blood stages of malaria	Perrin, Abigail	2014	Abigail Perrin's thesis tar.gz file
Spatial analysis of complex biological tissues from single cell gene expression data: clustering and visualizing functional tissues in Platynereis dumerilii’s brain	Pettit, Jean-Baptiste O G	2014	Not available
Defining the Clostridium difficile spo0A regulon and its role in disease and transmission	Pettit, Laura J	2012	Laura J Pettit's thesis tar.gz file
Isolation of homozygous mutant mouse embryonic stem cells by selection for copy number increase	Pettitt, Stephen J	2011	Stephen J Pettitt's thesis tar.gz file
Analysis of IncHI1 plasmids in Salmonella enterica serovar Typhi	Phan, Minh-Duy	2009	Minh-Duy Phan's thesis tar.gz file
Inference and classification of eukaryotic cis-regulatory motifs	Piipari, Matias	2010	Matias Piipari's thesis tar.gz file
Computational Analysis of Genomes	Pocock, Matthew R	2003	Matthew R Pocock's thesis tar.gz file
The Zebrafish Homologues of JAM-B and JAM-C are Essential for Myoblast Fusion	Powell, Gareth T	2010	Gareth T Powell's thesis tar.gz file
Transcriptome characterisation of cercariae and skin-stage schistosomula in the parasitic helminth Schistosoma mansoni.	Protasio, Anna V	2011	Anna V Protasio's thesis tar.gz file
Computational detection of gene regulatory signals in human genome sequence	Ramadass, Aroul S	2004	Aroul S Ramadass' thesis tar.gz file
Genome Evolution: A study of MHC paralogous genes in the human genome	Rand, Vikki	2003	Vikki Rand's thesis tar.gz file
Neural network-based methods for large scale protein sequence analysis.	Reinhardt, Astrid	1999	Not available
Patterns of somatic genome rearrangement in human cancer	Roberts, Nicola Diane	2018	Nicola Diane Roberts' thesis tar.gz file
Murine embryonic stem cells as a route towards exploring host-pathogen interactions	Rossi, Raffaella	2008	Raffaella Rossi's thesis tar.gz file
Periodic gene expression program of the fission yeast cell cycle	Rustici, Gabriella	2004	Gabriella Rustici's thesis tar.gz file
Functional investigation of NMDA receptor molecular evolution	Ryan, Tomas	2010	Not available
The influence of genetics on gamma-herpesvirus infections	Sallah, Neneh	2016	Neneh Sallah's thesis tar.gz file
Analysis of gene amplification in human cancer	Santarius, Tom	2009	Not available
The role of protein interactions in evolution and disease	Schuster-Bockler, Benjamin	2008	Benjamin Schuster-Bockler's thesis tar.gz file
Using molecular QTLs to identify cell types and causal variants for complex traits	Schwartzentruber, Jeremy	2017	Jeremy Schwartzentruber's thesis tar.gz file
The role of the CapZ complex in vertebrate sarcomere integrity	Scott, Annabelle	2007	Annabelle Scott's thesis tar.gz file
Efficient sequence assembly and variant calling using compressed data structures	Simpson, Jared	2012	Jared Simpson's thesis tar.gz file
The contribution of rare variants to risk of schizophrenia and neurodevelopmental disorders	Singh, Tarjinder	2017	Tarjinder Singh's thesis tar.gz file
Genome studies of human chromosome 22q13.3.	Smink, Luc	2000	Not available
The Function and Genetics of the Host IFITM Locus	Smith, Sarah	2014	Sarah Smith's thesis tar.gz file
Genetic and environmental regulation of olfactory sensory neurone diversity	Soria, Ximena Ibarra	2015	Ximena Ibarra Soria's thesis tar.gz file
Human chromosome 20q12-13.2: Structural, comparative and sequence variation studies	Stavrides, George	2002	George Stavrides' thesis tar.gz file
Methods for genome-scale gene perturbation studies of the TRAIL-induced apoptosis pathway in mammalian cell culture	Sudbery, Ian	2007	Ian Sudbery's thesis tar.gz file
Fine-mapping and functional analyses of genetic variants driving local adaptations in humans	Szpak, Michal	2016	Michal Szpak's thesis tar.gz file
Copy Number Variation and Schizophrenia	Tam, Gloria Wing Chi	2008	Gloria Wing Chi Tam's thesis tar.gz file
The targets and role of palmitoylation in Plasmodium parasites	Tay, Chwen Ling	2014	Chwen Ling Tay's thesis tar.gz file
Molecular characterisation of the candidate region for bronx waltzer: a mouse model of hearing impairment	Taylor, Amy	2005	Amy Taylor's thesis tar.gz file
Analysis of genes controlling notochord development in zebrafish	Thomas, Kevin	2005	Kevin Thomas' thesis tar.gz file
Characterization of a Novel Deletion Allele of Brca1	Thompson, Debrah M	2003	Debrah M Thompson's thesis tar.gz file
Systematic Analysis of the Evolution and Conservation of Genetic Interactions Using C. elegans as a Model System	Tischler, Julia	2007	Julia Tischler's thesis tar.gz file
Identification and Characterisation of Differentially Methylated Regions within the human Major Histocompatibility Complex	Tomazou, Eleni M	2008	Eleni M Tomazou's thesis tar.gz file
In silico prediction of Genomic In Islands in microbial genomes Islands	Vernikos, George	2008	George Vernikos' thesis tar.gz file
Biochemical investigations of Plasmodium falciparum erythrocyte invasion pathways using recombinant merozoite surface proteins produced in a mammalian expression system	Wanaguru, Madushi	2012	Madushi Wanaguru's thesis tar.gz file
Characterization of BCL11 functions in the mouse mammary gland identifies two types of mammary stem cells	Wang, Juexuan	2012	Not available
Chromosome-specific Recessive Genetic Screen for Genes Involved in In Vitro Differentiation in Mouse Embyonic Stem Cells	Wang, Wei	2005	Wei Wang's thesis tar.gz file
Transcriptomic studies on host-parasite interactions in Schistosoma mansoni intramammalian stages	Wangwiwatsin, Arporn	2017	Arporn Wangwiwatsin's thesis tar.gz file
Analysis of short tandem repeat variation in large scale resequencing data	Whitener, Weldon	2011	Weldon Whitener's thesis tar.gz file
Application of DNA Microarrays to Assess DNA Replication Timing and Chromosomal Aberrations	Woodfine, Kathryn	2003	Kathryn Woodfine's thesis tar.gz file
Genome-wide recessive screens for DNA mismatch repair genes in mouse ES cells	Xiong, Zikai	2008	Zikai Xiong's thesis tar.gz file
Biological Investigations through sequence analysis	Yeats, Corin	2004	Corin Yeats' thesis tar.gz file
Progressive hearing loss in mouse mutants	Yen, Jennifer	2012	Not available
Evolution by Gene Loss?	Yngvadottir, Bryndis	2008	Bryndis Yngvadottir's thesis tar.gz file
Identification and analysis of MHC-linked olfactory receptor genes	Younger, Ruth	2002	Ruth Younger's thesis tar.gz file
Applying recombinant protein technology to study Plasmodium falciparum erythrocyte receptor-ligand interactions and their potential as therapeutic targets	Zenonos, Zenon	2013	Zenon Zenonos' thesis tar.gz file
Mapping synaptic heterogeneity of MAGUK family members in fluorescent protein knockin mice	Zhu, Fei	2012	Not available

MPhil Theses

Title	Author	Year	Thesis
Development of a Resource for the Exploration of Gene Expression in the Mouse Foetus	Campbell, Elizabeth A	2004	Elizabeth A Campbell's thesis tar.gz file
Characterisation of the transcriptional response to cytokine induced polarisation in human CD4⁺ T cells and monocyte derived macrophages	Gámez, Eddie Cano	2017	Eddie Cano Gámez's thesis tar.gz file
The relationship of identity by state to identity by descent and imputation accuracy in population sequencing data	Harris, Kelley	2011	Kelley Harris' thesis tar.gz file
Phenotypic variation in erythrocyte invasion by Plasmodium falciparum isolates from Peru	Hesketh, Richard	2011	Richard Hesketh's thesis tar.gz file
Overexpression of Mammalian Nanog mRNA Hyperdorsalises Zebrafish Embryos	Jiang, Ying	2011	Ying Jiang's thesis tar.gz file
Evaluating the Efficacy of Epigenetic Imputation in CD4+ Regulatory T Cells	Kumar Thurimella, Kiran	2018	Kiran Kumar Thurimella's thesis tar.gz file
Bioinformatics approaches to RNA splicing	Levine, Aaron	2001	Aaron Levine's thesis tar.gz file
Somatic mutations in the pancreatic islets	Nicola, Pantelis Andreas	2018	Pantelis Andreas Nicola's thesis tar.gz file
Bioinformatic Analysis of Imprinted CpG Islands in Mus musculus	Riordan, Daniel	2003	Daniel Riordan's thesis tar.gz file