Fengtang Yang

Senior Staff Scientist

I am a molecular cytogeneticist by training but have stayed abreast of the latest developments in the field of molecular biology and genomics throughout my career. I study chromosomes, their structure, inheritance and evolution by fluorescence in situ hybridisation (FISH) - a technique for detecting and locating specific DNA sequences on metaphase chromosome and interphase nuclei - in combination with conventional cytogenetic banding techiques.

Before I moved to the Sanger Institute, my research maninly invloved 1) the development of chromosome-specific paint probes by flow sorting and DOP-PCR amplification and 2) the characterisaiton of major evolutionary chromosomal rearrangements in eutherian mammals and birds by cross-species chromosome painting.

After join the Sanger Institute, my search mainly focused on the high-thoughput and high-resolution mapping of genomic DNA clones (BACs & fosmids) by multicolour FISH in order to assit the assembly of genomic sequences, such as the chromosomal assignment and ordering of sequence contigs, sizing of gaps and overlaps in genome assemblies, validation of structural and copy number varaitions, mapping of mouse transgenes, characterisation of chromosomal structural and numerical aberations in cancer cell lines and in mouse models of human tumours, karyotyping of ESC ad iPSC lines from human and mouse etc.

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