This person is a member of Sanger Institute Alumni.
Bromodomain-containing proteins (BDPs) bind to acetylated lysine residues to stimulate nucleosome accesibility and transcriptional activity. The malaria-causing parasite, Plasmodium falciparum, contains 10 such BDPs, which are increasingly thought to be potential antimalarial drug targets. My role in the Lee group focuses on the disruptive knock out of these BDPs and analysing the fitness cost to the parasite, in order to investigate the potentially essential role these proteins play in the asexual blood stage.
Wellcome Sanger Institute