Dr Lu Yu | Senior Staff Scientist

Yu, Lu

Lu’s research interest is protein and peptide analysis using multi-dimensional HPLC and nanoLC-MS/MS methods, including protein identification and characterisation, protein post-translational modifications such as phosphorylation, palmitoylation and ubiquitination, and protein quantification. In addition, she also supports bioinformatics development in the team for efficient data mining and result generation. Due to the various collaborations both internally and externally, she also gives training to students, post-doctors and visiting scientists about MS sample preparation and data processing skills.


  • A new method to determine in vivo interactomes reveals binding of the Legionella pneumophila effector PieE to multiple rab GTPases.

    Mousnier A, Schroeder GN, Stoneham CA, So EC, Garnett JA et al.

    mBio 2014;5;4

  • Functional genomics reveals that Clostridium difficile Spo0A coordinates sporulation, virulence and metabolism.

    Pettit LJ, Browne HP, Yu L, Smits WK, Fagan RP et al.

    BMC genomics 2014;15;160

  • Quantitative RNA-seq analysis of the Campylobacter jejuni transcriptome.

    Chaudhuri RR, Yu L, Kanji A, Perkins TT, Gardner PP et al.

    Microbiology (Reading, England) 2011;157;Pt 10;2922-32

  • An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.

    Pardo M, Lang B, Yu L, Prosser H, Bradley A et al.

    Cell stem cell 2010;6;4;382-95

  • Proteomic and genomic characterization of highly infectious Clostridium difficile 630 spores.

    Lawley TD, Croucher NJ, Yu L, Clare S, Sebaihia M et al.

    Journal of bacteriology 2009;191;17;5377-86

  • Accurate and sensitive peptide identification with Mascot Percolator.

    Brosch M, Yu L, Hubbard T and Choudhary J

    Journal of proteome research 2009;8;6;3176-81

  • Phosphoproteomic analysis of the mouse brain cytosol reveals a predominance of protein phosphorylation in regions of intrinsic sequence disorder.

    Collins MO, Yu L, Campuzano I, Grant SG and Choudhary JS

    Molecular & cellular proteomics : MCP 2008;7;7;1331-48

  • Proteomic analysis of in vivo phosphorylated synaptic proteins.

    Collins MO, Yu L, Coba MP, Husi H, Campuzano I et al.

    The Journal of biological chemistry 2005;280;7;5972-82

  • The three-dimensional structure and X-ray sequence reveal that trichomaglin is a novel S-like ribonuclease.

    Gan JH, Yu L, Wu J, Xu H, Choudhary JS et al.

    Structure (London, England : 1993) 2004;12;6;1015-25

  • Epitope mapping of monoclonal antibodies by mass spectrometry: identification of protein antigens in complex biological systems.

    Yu L, Gaskell SJ and Brookman JL

    Journal of the American Society for Mass Spectrometry 1998;9;3;208-15

Yu, Lu
Lu's Timeline

Senior Staff Scientist, Wellcome Trust Sanger Institute


Research Scientist, Cellzome UK


Passed PhD viva


Research Scientist, Cell Map Project, GlaxoSmithKline (Stevenage)


Started PhD, Michael Barber Centre for Mass Spectrometry, UMIST


Visiting Scientist in Michael Barber Centre for Mass Spectrometry, University of Manchester Institute of Science and Technology (UMIST)


Research Associate, Organic Mass Spectrometry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences


Research Assistant, Organic Mass Spectrometry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

MSc in Analytical Chemistry, Fudan University, Shanghai, China


BSc in Chemistry, Fudan University, Shanghai, China