Yu, Jason Shu Lim
Jason is a Postdoctoral Research Fellow whose research interests centre around investigating the genetic mechanims that regulate differentiation and reprogramming. He is particularly interested in the use of genome-wide forward genetic screens to identify novel factors that contribute to these processes.
My previous work focused on using human embryonic stem cells as a cell model from which to interrogate the signalling mechanisms governing the derivation of hepatic and neural precursors.
Currently, as part of the Yusa group, I am utilising CRISPR/Cas9 mediated genome-wide screening approaches to identify reprogramming factors involved in the conversion of adult heart fibroblast into cardiac progenitor cells.
This is in collaboration with AstraZeneca, with the ultimate goal of being able to develop new drugs which can facilitate this reprogramming in vivo.
Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination.
Development (Cambridge, England) 2016;143;17;3050-60
PI3K/mTORC2 regulates TGF-β/Activin signalling by modulating Smad2/3 activity via linker phosphorylation.
Nature communications 2015;6;7212
TRF2-mediated stabilization of hREST4 is critical for the differentiation and maintenance of neural progenitors.
Stem cells (Dayton, Ohio) 2014;32;8;2111-22
Application of three-dimensional culture conditions to human embryonic stem cell-derived definitive endoderm cells enhances hepatocyte differentiation and functionality.
Tissue engineering. Part A 2013;19;3-4;360-7
Identification and characterisation of the early differentiating cells in neural differentiation of human embryonic stem cells.
PloS one 2012;7;5;e37129