Dr Kelvin Tuong | Visiting Scientist

Tuong, Zewen Kelvin

Kelvin is a computational immunologist interested in single-cell analysis of tissue resident macrophages in health and disease.

He attained his PhD in macrophage cell biology and endocrinology at The University of Queensland (UQ), Australia and went on to a post-doc position with Prof. Ian Frazer (co-inventor of the Gardasil cervical cancer vaccine, UQ Diamantina Institute, Translational Research Institute) where he worked on HPV immunology, cervical cancer and skin cancer.  In his time in the Frazer lab, he developed an interest in bioinformatics analyses as a means to tackle and understanding immunology problems in health and disease.

He is now applying his skillsets in his second post-doc position with Prof. Menna Clatworthy, with a visiting appointment with the Teichmann lab, where is primarily interested in single-cell analyses of tissue resident macrophages and lymphoid cells in kidneys and prostate.

Publications

  • Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

    Lukowski SW, Tuong ZK, Noske K, Senabouth A, Nguyen QH et al.

    The Journal of investigative dermatology 2018;138;12;2558-2567

  • Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: A prospective observational study.

    Zammit AP, Sinha R, Cooper CL, Perry CFL, Frazer IH and Tuong ZK

    PloS one 2018;13;10;e0205406

  • Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

    Tuong ZK, Fitzsimmons R, Wang SM, Oh TG, Lau P et al.

    EBioMedicine 2016;11;101-117

  • A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.

    Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH and Tuong ZK

    EBioMedicine 2016;9;314-323

  • RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

    Tuong ZK, Lau P, Du X, Condon ND, Goode JM et al.

    PloS one 2016;11;1;e0147179

  • Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.

    Lau P, Tuong ZK, Wang SC, Fitzsimmons RL, Goode JM et al.

    American journal of physiology. Endocrinology and metabolism 2015;308;2;E159-71

  • Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.

    Tuong ZK, Lau P, Yeo JC, Pearen MA, Wall AA et al.

    Endocrinology 2013;154;1;140-9

  • Single-cell RNA sequencing reveals cell type-specific HPV expression in hyperplastic skin lesions.

    Devitt K, Hanson SJ, Tuong ZK, McMeniman E, Soyer HP et al.

    Virology 2019;537;14-19

  • HPV16 E7-Driven Epithelial Hyperplasia Promotes Impaired Antigen Presentation and Regulatory T-Cell Development.

    Bashaw AA, Teoh SM, Tuong ZK, Leggatt GR, Frazer IH and Chandra J

    The Journal of investigative dermatology 2019

  • Mechanism of Iron Oxide-Induced Macrophage Activation: The Impact of Composition and the Underlying Signaling Pathway.

    Gu Z, Liu T, Tang J, Yang Y, Song H et al.

    Journal of the American Chemical Society 2019;141;15;6122-6126

  • Papillomavirus Immune Evasion Strategies Target the Infected Cell and the Local Immune System.

    Zhou C, Tuong ZK and Frazer IH

    Frontiers in oncology 2019;9;682

  • Detection of HPV E7 Transcription at Single-Cell Resolution in Epidermis.

    Lukowski SW, Tuong ZK, Noske K, Senabouth A, Nguyen QH et al.

    The Journal of investigative dermatology 2018;138;12;2558-2567

  • HPV16E7-Induced Hyperplasia Promotes CXCL9/10 Expression and Induces CXCR3+ T-Cell Migration to Skin.

    Kuo P, Tuong ZK, Teoh SM, Frazer IH, Mattarollo SR and Leggatt GR

    The Journal of investigative dermatology 2018;138;6;1348-1359

  • Characterization of 7A7, an anti-mouse EGFR monoclonal antibody proposed to be the mouse equivalent of cetuximab.

    He X, Cruz JL, Joseph S, Pett N, Chew HY et al.

    Oncotarget 2018;9;15;12250-12260

  • B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity.

    McKee SJ, Tuong ZK, Kobayashi T, Doff BL, Soon MS et al.

    Oncoimmunology 2018;7;2;e1393599

  • Examining the contribution of smoking and HPV towards the etiology of oral cavity squamous cell carcinoma using high-throughput sequencing: A prospective observational study.

    Zammit AP, Sinha R, Cooper CL, Perry CFL, Frazer IH and Tuong ZK

    PloS one 2018;13;10;e0205406

  • Recruitment of Antigen Presenting Cells to Skin Draining Lymph Node From HPV16E7-Expressing Skin Requires E7-Rb Interaction.

    Kuo P, Teoh SM, Tuong ZK, Leggatt GR, Mattarollo SR and Frazer IH

    Frontiers in immunology 2018;9;2896

  • Modulation of antigen presenting cell functions during chronic HPV infection.

    Bashaw AA, Leggatt GR, Chandra J, Tuong ZK and Frazer IH

    Papillomavirus research (Amsterdam, Netherlands) 2017;4;58-65

  • Transgenic Adipose-specific Expression of the Nuclear Receptor RORα Drives a Striking Shift in Fat Distribution and Impairs Glycemic Control.

    Tuong ZK, Fitzsimmons R, Wang SM, Oh TG, Lau P et al.

    EBioMedicine 2016;11;101-117

  • A Mouse Model of Hyperproliferative Human Epithelium Validated by Keratin Profiling Shows an Aberrant Cytoskeletal Response to Injury.

    Zhussupbekova S, Sinha R, Kuo P, Lambert PF, Frazer IH and Tuong ZK

    EBioMedicine 2016;9;314-323

  • The Nuclear Receptor, Nor-1, Induces the Physiological Responses Associated With Exercise.

    Goode JM, Pearen MA, Tuong ZK, Wang SC, Oh TG et al.

    Molecular endocrinology (Baltimore, Md.) 2016;30;6;660-76

  • RORα and 25-Hydroxycholesterol Crosstalk Regulates Lipid Droplet Homeostasis in Macrophages.

    Tuong ZK, Lau P, Du X, Condon ND, Goode JM et al.

    PloS one 2016;11;1;e0147179

  • Rorα deficiency and decreased adiposity are associated with induction of thermogenic gene expression in subcutaneous white adipose and brown adipose tissue.

    Lau P, Tuong ZK, Wang SC, Fitzsimmons RL, Goode JM et al.

    American journal of physiology. Endocrinology and metabolism 2015;308;2;E159-71

  • Transgenic muscle-specific Nor-1 expression regulates multiple pathways that effect adiposity, metabolism, and endurance.

    Pearen MA, Goode JM, Fitzsimmons RL, Eriksson NA, Thomas GP et al.

    Molecular endocrinology (Baltimore, Md.) 2013;27;11;1897-917

  • Disruption of Rorα1 and cholesterol 25-hydroxylase expression attenuates phagocytosis in male Rorαsg/sg mice.

    Tuong ZK, Lau P, Yeo JC, Pearen MA, Wall AA et al.

    Endocrinology 2013;154;1;140-9

Tuong, Zewen Kelvin
Kelvin's Timeline
2019

Joined Teichmann Lab (Visiting worker)

Post-doc with Prof. Menna Clatworthy (University of Cambridge)

2017

Advance Queensland Early Career Research Fellowship

2016

Graduate with PhD

2015

Post-doc with Prof. Ian Frazer (UQ, Australia)