Talman, Arthur M
My current research focuses on understanding the strategies and patterns observed during malaria sexual reproduction. Male and female parasites are picked up during mosquito feeding, mate in the blood meal and are responsible for malaria transmission. The aim of my research is to understand how distinct parasite populations interact during this process.
Throughout my studies I have been interested in host-pathogen interactions and mechanisms of malaria transmission. In particular, I participated in field studies of apicomplexan parasite transmission in rural Africa and Southeast Asia. For my PhD at Imperial College London, I investigated malaria sexual reproduction and transmission to Anopheline mosquitoes from a molecular perspective. I recently completed my post-doctoral training by conducting research into dissemination of bacterial and viral pathogens at the Yale School of Medicine’s Microbial Pathogenesis department. I joined Mara Lawniczak group in February 2015.
Bacterial spread from cell to cell: beyond actin-based motility.
Trends in microbiology 2015;23;9;558-66
An essential role of the basal body protein SAS-6 in Plasmodium male gamete development and malaria transmission.
Cellular microbiology 2015;17;2;191-206
Proteomic analysis of the Plasmodium male gamete reveals the key role for glycolysis in flagellar motility.
Malaria journal 2014;13;315
Actin network disassembly powers dissemination of Listeria monocytogenes.
Journal of cell science 2014;127;Pt 1;240-9
PbGEST mediates malaria transmission to both mosquito and vertebrate host.
Molecular microbiology 2011;82;2;462-74
The Armadillo repeat protein PF16 is essential for flagellar structure and function in Plasmodium male gametes.
PloS one 2010;5;9;e12901
Heritability of the human infectious reservoir of malaria parasites.
PloS one 2010;5;6;e11358
A Plasmodium falciparum strain expressing GFP throughout the parasite's life-cycle.
PloS one 2010;5;2;e9156
Attraction between sexes: male-female gametocyte behaviour within a Leucocytozoon toddi (Haemosporida).
Parasitology research 2008;102;6;1321-7
Influence of chemotherapy on the Plasmodium gametocyte sex ratio of mice and humans.
The American journal of tropical medicine and hygiene 2004;71;6;739-44