Malaria parasites sexually reproduce in the mosquito vector, which is an essential lifecycle stage and vital for disease transmission. Blocking transmission will play a key role in malaria eradication, and I am designing genetic screens using the PlasmoGEM resource and single-cell RNA sequencing to investigate the mechanisms of malaria fertility.
A genetic screen in rodent malaria parasites identifies five new apicoplast putative membrane transporters, one of which is essential in human malaria parasites.
Cellular microbiology 2018;20;1
Targeting of a Transporter to the Outer Apicoplast Membrane in the Human Malaria Parasite Plasmodium falciparum.
PloS one 2016;11;7;e0159603