My research focuses on deep profiling of protein expression and modification for molecular phenotyping of biological systems with natural or induced variation. I am interested in the integration of multi-omics technologies to better understand gene expression regulation under pathological conditions such as cancer and infection.
Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.
Nature cell biology 2013;15;8;967-77
Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis.
Journal of proteome research 2009;8;1;362-73
The shotgun proteomic study of the human ThinPrep cervical smear using iTRAQ mass-tagging and 2D LC-FT-Orbitrap-MS: the detection of the human papillomavirus at the protein level.
Journal of proteome research 2013;12;5;2078-89
Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level.
Journal of proteome research 2013;12;4;1591-603
Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer.
Molecular & cellular proteomics : MCP 2015;14;7;1814-30
Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30;20;6838-51
CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.