Dr Theodoros Roumeliotis | Staff Scientist

This person is a member of Sanger Institute Alumni.

Roumeliotis, Theodoros

My research focuses on deep profiling of protein expression and modification for molecular phenotyping of biological systems with natural or induced variation. I am interested in the integration of multi-omics technologies to better understand gene expression regulation under pathological conditions such as cancer and infection.

Publications

  • Functional interplay between the DNA-damage-response kinase ATM and ARF tumour suppressor protein in human cancer.

    Velimezi G, Liontos M, Vougas K, Roumeliotis T, Bartkova J et al.

    Nature cell biology 2013;15;8;967-77

  • Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis.

    Bouchal P, Roumeliotis T, Hrstka R, Nenutil R, Vojtesek B and Garbis SD

    Journal of proteome research 2009;8;1;362-73

  • The shotgun proteomic study of the human ThinPrep cervical smear using iTRAQ mass-tagging and 2D LC-FT-Orbitrap-MS: the detection of the human papillomavirus at the protein level.

    Papachristou EK, Roumeliotis TI, Chrysagi A, Trigoni C, Charvalos E et al.

    Journal of proteome research 2013;12;5;2078-89

  • Pharmacoproteomic study of the natural product Ebenfuran III in DU-145 prostate cancer cells: the quantitative and temporal interrogation of chemically induced cell death at the protein level.

    Roumeliotis TI, Halabalaki M, Alexi X, Ankrett D, Giannopoulou EG et al.

    Journal of proteome research 2013;12;4;1591-603

  • Combined Proteomics and Transcriptomics Identifies Carboxypeptidase B1 and Nuclear Factor κB (NF-κB) Associated Proteins as Putative Biomarkers of Metastasis in Low Grade Breast Cancer.

    Bouchal P, Dvořáková M, Roumeliotis T, Bortlíček Z, Ihnatová I et al.

    Molecular & cellular proteomics : MCP 2015;14;7;1814-30

  • Cell-produced alpha-synuclein is secreted in a calcium-dependent manner by exosomes and impacts neuronal survival.

    Emmanouilidou E, Melachroinou K, Roumeliotis T, Garbis SD, Ntzouni M et al.

    The Journal of neuroscience : the official journal of the Society for Neuroscience 2010;30;20;6838-51

  • CDK/CK1 inhibitors roscovitine and CR8 downregulate amplified MYCN in neuroblastoma cells.

    Delehouzé C, Godl K, Loaëc N, Bruyère C, Desban N et al.

    Oncogene 2014;33;50;5675-87

Roumeliotis, Theodoros