Raheleh Rahbari is a Cancer Research UK Career Development Fellow, her research focuses on mutations acquired during ageing and how they can predispose to disease across generations.
Active areas of interest include: studying the variation in germline mutation rates across families, mutational processes operative in the germline, the impact of germline genetic mosaicism in offspring, and using somatic mutations to infer the clonal dynamics of germline tissues.
As a member of the INSTALZ consortium, I am also using single cell multi-omics approaches to study somatic heterogeneity in human neuronal cells and their role in Alzheimer’s disease.
Timing, rates and spectra of human germline mutation.
Nature genetics 2016;48;2;126-133
Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.
Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.
Nature communications 2017;8;1;303
Detection of structural mosaicism from targeted and whole-genome sequencing data.
Genome research 2017;27;10;1704-1714