Dr Raheleh Rahbari | Cancer Research Career Development Fellow

Rahbari, Raheleh

Raheleh Rahbari is a Cancer Research UK Career Development Fellow, her research focuses on mutations acquired during ageing and how they can predispose to disease across generations.

Active areas of interest include: studying the variation in germline mutation rates across families, mutational processes operative in the germline, the impact of germline genetic mosaicism in offspring, and using somatic mutations to infer the clonal dynamics of germline tissues.

As a member of the INSTALZ consortium, I am also using single cell multi-omics approaches to study somatic heterogeneity in human neuronal cells and their role in Alzheimer’s disease. 

Publications

  • Timing, rates and spectra of human germline mutation.

    Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB et al.

    Nature genetics 2016;48;2;126-133

  • Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

    Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB et al.

    Nature 2017;543;7647;714-718

  • Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.

    Narasimhan VM, Rahbari R, Scally A, Wuster A, Mason D et al.

    Nature communications 2017;8;1;303

  • Detection of structural mosaicism from targeted and whole-genome sequencing data.

    King DA, Sifrim A, Fitzgerald TW, Rahbari R, Hobson E et al.

    Genome research 2017;27;10;1704-1714

  • Detection of structural mosaicism from targeted and whole-genome sequencing data.

    King DA, Sifrim A, Fitzgerald TW, Rahbari R, Hobson E et al.

    Genome research 2017;27;10;1704-1714

  • Estimating the human mutation rate from autozygous segments reveals population differences in human mutational processes.

    Narasimhan VM, Rahbari R, Scally A, Wuster A, Mason D et al.

    Nature communications 2017;8;1;303

  • Understanding the Genomic Structure of Copy-Number Variation of the Low-Affinity Fcγ Receptor Region Allows Confirmation of the Association of FCGR3B Deletion with Rheumatoid Arthritis.

    Rahbari R, Zuccherato LW, Tischler G, Chihota B, Ozturk H et al.

    Human mutation 2017;38;4;390-399

  • Somatic mutations reveal asymmetric cellular dynamics in the early human embryo.

    Ju YS, Martincorena I, Gerstung M, Petljak M, Alexandrov LB et al.

    Nature 2017;543;7647;714-718

  • Timing, rates and spectra of human germline mutation.

    Rahbari R, Wuster A, Lindsay SJ, Hardwick RJ, Alexandrov LB et al.

    Nature genetics 2016;48;2;126-133

  • Combining Amplification Typing of L1 Active Subfamilies (ATLAS) with High-Throughput Sequencing.

    Rahbari R and Badge RM

    Methods in molecular biology (Clifton, N.J.) 2016;1400;95-106

  • Transduction-specific ATLAS reveals a cohort of highly active L1 retrotransposons in human populations.

    Macfarlane CM, Collier P, Rahbari R, Beck CR, Wagstaff JF et al.

    Human mutation 2013;34;7;974-85

  • IAP display: a simple method to identify mouse strain specific IAP insertions.

    Ray A, Rahbari R and Badge RM

    Molecular biotechnology 2011;47;3;243-52

  • A novel L1 retrotransposon marker for HeLa cell line identification.

    Rahbari R, Sheahan T, Modes V, Collier P, Macfarlane C and Badge RM

    BioTechniques 2009;46;4;277-84

Career/Research Highlights

Rahbari, Raheleh
Raheleh's Timeline
2019

Cancer Research UK Career Development Fellowship

2016

Senior PDF in Voets Faculty Single Cell Genomics Group | Sanger Institute

2013

PDF in Hurles Faculty Department of Human Genetics | Sanger Institute

2012

PhD awarded in Medical Genetics | University of Leicester