I have developed a resource of micro RNA knockouts in murine embryonic stem cells which is publicly available from the repositories EuMMCR at Munich, and MMRRC at UC Davis USA.
I am also involved in chromosomal engineering; having developed methods for site specific transgenesis I am currently applying similar techniques to humanize mouse genetic loci.
Independent regulation of vertebral number and vertebral identity by microRNA-196 paralogs.
Proceedings of the National Academy of Sciences of the United States of America 2015;112;35;E4884-93
Genetic and hypoxic alterations of the microRNA-210-ISCU1/2 axis promote iron-sulfur deficiency and pulmonary hypertension.
EMBO molecular medicine 2015;7;6;695-713
MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production.
Journal of immunology (Baltimore, Md. : 1950) 2013;191;6;3037-3048
ATR acts stage specifically to regulate multiple aspects of mammalian meiotic silencing.
Genes & development 2013;27;13;1484-94
Multi-isotope imaging mass spectrometry reveals slow protein turnover in hair-cell stereocilia.
A resource of vectors and ES cells for targeted deletion of microRNAs in mice.
Nature biotechnology 2011;29;9;840-5
Evidence that meiotic sex chromosome inactivation is essential for male fertility.
Current biology : CB 2010;20;23;2117-23
An expanded Oct4 interaction network: implications for stem cell biology, development, and disease.
Cell stem cell 2010;6;4;382-95
Agouti C57BL/6N embryonic stem cells for mouse genetic resources.
Nature methods 2009;6;7;493-5
A DNA transposon-based approach to validate oncogenic mutations in the mouse.
Proceedings of the National Academy of Sciences of the United States of America 2008;105;50;19904-9
Mosaic complementation demonstrates a regulatory role for myosin VIIa in actin dynamics of stereocilia.
Molecular and cellular biology 2008;28;5;1702-12
Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei.
Proceedings of the National Academy of Sciences of the United States of America 2007;104;2;648-53