Han is a Postdoctoral Fellow working on cell surface proteins of Leishmania donovani to identify possible vaccination candidates.
Leishmaniasis is a parasitic disease caused by infections of Leishmania spp.; It can be classified into cutaneous, mucocutaneous, or visceral forms. Currently ~12 million people in 98 countries infected with the disease. Visceral leishmaniasis (VL) is the most severe form of the disease and is almost always fatal if left untreated. VL is caused by Leishmania donovani and there is currently no vaccine available to prevent the disease. The primary goal of the project is to study the cell surface proteins of L. donovani to identify suitable antigens for the development of vaccines in the future.
Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei.
Molecular microbiology 2015;95;1;143-56
Trypanosoma brucei (UMP synthase null mutants) are avirulent in mice, but recover virulence upon prolonged culture in vitro while retaining pyrimidine auxotrophy.
Molecular microbiology 2013;90;2;443-55
Design, synthesis and biological evaluation of novel inhibitors of Trypanosoma brucei pteridine reductase 1.
Dissecting the metabolic roles of pteridine reductase 1 in Trypanosoma brucei and Leishmania major.
The Journal of biological chemistry 2011;286;12;10429-38
Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice.
Molecular microbiology 2010;77;3;658-71
Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase.
Analytical biochemistry 2010;396;2;194-203