Alice is an Operations Manager for Open Targets, an innovative, public-private partnership that uses large-scale genetics and genomics data to systematically identify and prioritise drug targets.
Alice aims to use her scientific expertise and background in genomics to facilitate the smooth running of Open Targets experimental projects that utilise cutting-edge technologies and approaches. Alice also supports Open Targets core operations, combining her knowledge of large-scale genetic studies and skills in project management, communication and strategic thinking. Alice works to the overall mission of the team; to create clarity, fight chaos and make things happen across all aspects of Open Targets.
Previously she worked as a Postdoctoral Fellow and PhD student for Professor Nicole Soranzo in Human Genetics at the Wellcome Sanger Institute. Her scientific background involved combining functional datasets with genetic studies to understand biological mechanisms at genetic risk loci and identify potential novel targets.
Alice's scientific background began in molecular and cellular biochemistry. During her Masters research, she was supervised by Professor Shona Murphy at the William Dunn School of Pathology, and investigated the mechanisms of transcriptional elongation of protein-coding genes. Later, Alice's PhD and postdoc research then combined her established knowledge of biology with the analysis of large-scale genetic and genomic datasets to further understand the functional consequences of regulatory genetic variation. In this work, she explored GWAS and genomic data in haematopoietic cell types and combined molecular and functional data to systematically interrogate loci of clinical importance. Alice's move to Open Targets was motivated by a desire to facilitate the translational benefit of genetics research by building on her skills gained beyond the research environment.
From GWAS to function: lessons from blood cells.
ISBT science series 2016;11;Suppl Suppl 1;211-219
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
Genetic Drivers of Epigenetic and Transcriptional Variation in Human Immune Cells.
Genome-wide analysis of differential transcriptional and epigenetic variability across human immune cell types.
Genome biology 2017;18;1;18
Common genetic variation drives molecular heterogeneity in human iPSCs.
Shared genetic effects on chromatin and gene expression indicate a role for enhancer priming in immune response.
Nature genetics 2018;50;3;424-431