Andrew currently uses functional genomics assays such as ATAC-seq, RNA-seq and ChIP-seq to provide sequencing data for the computational side of the Gaffney Faculty. The main focus is to map causal variants within human populations. Andrew is also using Cas9/CRISPR technology to validate putative causal SNPs.
Fine-mapping cellular QTLs with RASQUAL and ATAC-seq.
Nature genetics 2016;48;2;206-13
Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1.
Nucleic acids research 2015;43;20;9757-65
Extent, causes, and consequences of small RNA expression variation in human adipose tissue.
PLoS genetics 2012;8;5;e1002704
Coordinated regulation of foraging and metabolism in C. elegans by RFamide neuropeptide signaling.
Cell metabolism 2009;9;4;375-85