Christopher Jacob | Staff Scientist

Jacob, Christopher

My research focus is directed towards the use of genomics for understanding and solving clinical questions relating to the effective treatment of malaria. My work will include genotyping and data analysis of parasites collected as part of the reconnaissance project which monitors parasite populations and drug resistance in Southeast Asia.


  • A Single Mutation in K13 Predominates in Southern China and Is Associated With Delayed Clearance of Plasmodium falciparum Following Artemisinin Treatment.

    Huang F, Takala-Harrison S, Jacob CG, Liu H, Sun X et al.

    The Journal of infectious diseases 2015;212;10;1629-35

  • Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia.

    Takala-Harrison S, Jacob CG, Arze C, Cummings MP, Silva JC et al.

    The Journal of infectious diseases 2015;211;5;670-9

  • Genetic architecture of artemisinin-resistant Plasmodium falciparum.

    Miotto O, Amato R, Ashley EA, MacInnis B, Almagro-Garcia J et al.

    Nature genetics 2015;47;3;226-34

  • Plasmodium falciparum field isolates from areas of repeated emergence of drug resistant malaria show no evidence of hypermutator phenotype.

    Brown TS, Jacob CG, Silva JC, Takala-Harrison S, Djimdé A et al.

    Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2015;30;318-322

  • A microarray platform and novel SNP calling algorithm to evaluate Plasmodium falciparum field samples of low DNA quantity.

    Jacob CG, Tan JC, Miller BA, Tan A, Takala-Harrison S et al.

    BMC genomics 2014;15;719

  • A novel clade of unique eukaryotic ribonucleotide reductase R2 subunits is exclusive to apicomplexan parasites.

    Munro JB, Jacob CG and Silva JC

    Journal of molecular evolution 2013;77;3;92-106

  • Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia.

    Takala-Harrison S, Clark TG, Jacob CG, Cummings MP, Miotto O et al.

    Proceedings of the National Academy of Sciences of the United States of America 2013;110;1;240-5

  • Successful human infection with P. falciparum using three aseptic Anopheles stephensi mosquitoes: a new model for controlled human malaria infection.

    Laurens MB, Billingsley P, Richman A, Eappen AG, Adams M et al.

    PloS one 2013;8;7;e68969

Jacob, Christopher