Dr Ewan Harrison | Career Development Fellow

Harrison, Ewan

I am Career Development Fellow on a UKRI Innovation Fellowship as part of Cambridge Health Data Research (HDR) UK substantive site. I am also a Senior Research Associate in the Department of Medicine and a Honorary Fellow in the Department of Public Health and Primary Care at the University of Cambridge. 

I completed my PhD in 2010 on the genomics and pathogenesis of the opportunistic pathogen Pseudomonas aeruginosa. My post-doctoral work at the University of Cambridge focused on the analysis of Methicillin-resistant Staphylococcus aureus (MRSA) populations in animals and humans and tracking the transmission of MRSA in healthcare facilities using both computational and laboratory-based approaches. 

My current research focuses on the biology of S. aureus. In particular, I am interested in the biological basis of persistent nasal colonisation. To do this I am combining large cohort-based studies, microbiome sequencing, conventional microbiology and electronic health record data. I am also interested in understanding and overcoming mechanisms of beta-lactam resistance in S. aureus

Publications

  • The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.

    Wagner J, Harrison EM, Martinez Del Pero M, Blane B, Mayer G et al.

    Microbiome 2019;7;1;137

  • Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.

    Harrison EM, Ba X, Coll F, Blane B, Restif O et al.

    Nature microbiology 2019;4;10;1680-1691

  • Gene exchange drives the ecological success of a multi-host bacterial pathogen.

    Richardson EJ, Bacigalupe R, Harrison EM, Weinert LA, Lycett S et al.

    Nature ecology & evolution 2018;2;9;1468-1478

  • Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community.

    Coll F, Harrison EM, Toleman MS, Reuter S, Raven KE et al.

    Science translational medicine 2017;9;413

  • Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

    Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T et al.

    Scientific reports 2017;7;40660

  • Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks.

    Harrison EM, Ludden C, Brodrick HJ, Blane B, Brennan G et al.

    Genome medicine 2016;8;1;102

  • Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.

    Paterson GK, Harrison EM, Murray GGR, Welch JJ, Warland JH et al.

    Nature communications 2015;6;6560

  • A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals.

    Harrison EM, Weinert LA, Holden MT, Welch JJ, Wilson K et al.

    mBio 2014;5;3;e00985-13

  • Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC.

    Harrison EM, Paterson GK, Holden MT, Larsen J, Stegger M et al.

    EMBO molecular medicine 2013;5;4;509-15

  • The composition and functional protein subsystems of the human nasal microbiome in granulomatosis with polyangiitis: a pilot study.

    Wagner J, Harrison EM, Martinez Del Pero M, Blane B, Mayer G et al.

    Microbiome 2019;7;1;137

  • Genomic identification of cryptic susceptibility to penicillins and β-lactamase inhibitors in methicillin-resistant Staphylococcus aureus.

    Harrison EM, Ba X, Coll F, Blane B, Restif O et al.

    Nature microbiology 2019;4;10;1680-1691

  • Gene exchange drives the ecological success of a multi-host bacterial pathogen.

    Richardson EJ, Bacigalupe R, Harrison EM, Weinert LA, Lycett S et al.

    Nature ecology & evolution 2018;2;9;1468-1478

  • Longitudinal genomic surveillance of MRSA in the UK reveals transmission patterns in hospitals and the community.

    Coll F, Harrison EM, Toleman MS, Reuter S, Raven KE et al.

    Science translational medicine 2017;9;413

  • Identification of LukPQ, a novel, equid-adapted leukocidin of Staphylococcus aureus.

    Koop G, Vrieling M, Storisteanu DM, Lok LS, Monie T et al.

    Scientific reports 2017;7;40660

  • Transmission of methicillin-resistant Staphylococcus aureus in long-term care facilities and their related healthcare networks.

    Harrison EM, Ludden C, Brodrick HJ, Blane B, Brennan G et al.

    Genome medicine 2016;8;1;102

  • Capturing the cloud of diversity reveals complexity and heterogeneity of MRSA carriage, infection and transmission.

    Paterson GK, Harrison EM, Murray GGR, Welch JJ, Warland JH et al.

    Nature communications 2015;6;6560

  • A shared population of epidemic methicillin-resistant Staphylococcus aureus 15 circulates in humans and companion animals.

    Harrison EM, Weinert LA, Holden MT, Welch JJ, Wilson K et al.

    mBio 2014;5;3;e00985-13

  • Whole genome sequencing identifies zoonotic transmission of MRSA isolates with the novel mecA homologue mecC.

    Harrison EM, Paterson GK, Holden MT, Larsen J, Stegger M et al.

    EMBO molecular medicine 2013;5;4;509-15

Harrison, Ewan